Synovial sarcoma, X breakpoint

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Synovial sarcoma, X breakpoint (SSX) refers to a group of genes rearranged in synovial sarcoma.[1]

They include:

The group also has several associated pseudogenes, and the interacting protein SSX2IP.

The translocation t(X;18) creates a fusion of the SYT gene(at 18q11) with either SSX1 or SSX2 (both at Xp11). Neither SYT, nor the SSX proteins contain DNA-binding domains. Instead, they appear to be transcriptional regulators whose actions are mediated primarily through protein-protein interactions, with BRM in the case of SYT, and with Polycomb group repressors in the case of SSX. [2]

References[edit]

  1. ^ Valmori D, Qian F, Ayyoub M, et al. (January 2006). "Expression of synovial sarcoma X (SSX) antigens in epithelial ovarian cancer and identification of SSX-4 epitopes recognized by CD4+ T cells". Clin. Cancer Res. 12 (2): 398–404. doi:10.1158/1078-0432.CCR-05-1902. PMID 16428478. 
  2. ^ Ladanyi, M (2001). "Fusions of the SYT and SSX genes in synovial sarcoma". Oncogene 20 (40): 5755–62. doi:10.1038/sj.onc.1204601. PMID 11607825.  edit