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TRNA (guanine10-N2)-dimethyltransferase (EC2.1.1.213, PAB1283, N(2),N(2)-dimethylguanosine tRNA methyltransferase, Trm-G10, PabTrm-G10, PabTrm-m2 2G10 enzyme) is an enzyme with system name S-adenosyl-L-methionine:tRNA (guanine10-N2)-dimethyltransferase.[1] This enzyme catalyses the following chemical reaction
2 S-adenosyl-L-methionine + guanine10 in tRNA 2 S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA (overall reaction)
(1a) S-adenosyl-L-methionine + guanine10 in tRNA S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA
(1b) S-adenosyl-L-methionine + N2-methylguanine10 in tRNA S-adenosyl-L-homocysteine + N2-dimethylguanine10 in tRNA
References
^Armengaud, J., Urbonavicius, J., Fernandez, B., Chaussinand, G., Bujnicki, J.M. and Grosjean, H. (2004). "N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota". J. Biol. Chem. 279: 37142–37152. PMID15210688.{{cite journal}}: CS1 maint: multiple names: authors list (link)
