Talk:Beryllium poisoning

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Missing from article[edit]

One glaring omission is why Beryllium is poisonous. What's the mechanism of action; does it replace magnesium in the same way cadmium replaces zinc? Why is beryllium poisonous when boron, lithium, magnesium, and zinc aren't? Stonemason89 (talk) 15:57, 12 January 2011 (UTC)

From my related answer on RD/S: A 2006 review article (PMID 16697706) in Clinical Immunology suggested that particular MHC class II alleles (in HLA-DP) have negatively-charged glutamic acid residues capable of complexing beryllium, resulting in the broad activation of CD4+ T cells (reminiscent of the recent report in Science explaining the mechanisms of silver "allergy"). This is plausible though the phenotype is variable and it's likely to involve more factors; for example, a 2010 report PMID 20075058 suggests additional contribution of polymorphisms in CCR5, a chemokine receptor that has been shown to be important in T cell migration. The HLA-DP polymorphisms may provide the trigger, and the CCR5 polymorphisms may determine severity. -- Scray (talk) 14:42, 23 November 2012 (UTC)
I'll soon incorporate this into the article. -- Scray (talk) 04:22, 24 November 2012 (UTC)