|Jmol-3D images||Image 1|
|Molar mass||163.39 g mol−1|
|Melting point||57 to 58 °C; 135 to 136 °F; 330 to 331 K ()|
|Boiling point||197 °C; 387 °F; 470 K ()|
|Solubility in water||Soluble in 0.1 parts|
|Dipole moment||3.23 D|
|EU classification||Corrosive (C)
the environment (N)
|S-phrases||(S1/2), S26, S36/37/39,
S45, S60, S61
|LD50||5000 mg/kg orally in rats|
|Related chloroacetic acids||Chloroacetic acid
|Related compounds||Acetic acid
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
3COOH + 3Cl
2 → CCl
It is widely used in biochemistry for the precipitation of macromolecules, such as proteins, DNA, and RNA. Its sodium salt is used as a weedkiller. Solutions containing trichloroacetic acid as an ingredient are used for cosmetic treatments, such as chemical peels, tattoo removal, and the treatment of warts, including genital warts. It can kill normal cells as well. It is considered safe for use for this purpose during pregnancy.
Salts of trichloroacetic acid are called trichloroacetates. Reduction of trichloroacetic acid results in dichloroacetic acid, a pharmacologically active compound that shows promise for the treatment of cancer.
The discovery of trichloroacetic acid by Jean-Baptiste Dumas in 1839 delivered a striking example to the slowly evolving theory of organic radicals and valences. The theory was contrary to the beliefs of Jöns Jakob Berzelius, starting a long dispute between Dumas and Berzelius.
- Budavari, Susan, ed. (1996), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.), Merck, ISBN 0911910123
- Databog fysik kemi, F&K Forlaget 11. udgave 2009
- Wiley DJ, et al. (2002). External genital warts: Diagnosis, treatment, and prevention. Clinical Infectious Diseases, 35(Suppl 2): S210–S224
- The Carcinogenic Potency Database (CPDB)
- Dumas (1839). "Trichloroacetic acid". Annalen der Pharmacie 32: 101–119.
- William Albert Noyes (1927). "Valence". Proceedings of the American Philosophical Society 66: 287–308. JSTOR 3301070.