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Upstream transcription factor 2, c-fos interacting
Symbols USF2 ; FIP; bHLHb12
External IDs OMIM600390 MGI99961 HomoloGene2527 GeneCards: USF2 Gene
RNA expression pattern
PBB GE USF2 202152 x at tn.png
PBB GE USF2 214879 x at tn.png
PBB GE USF2 215737 x at tn.png
More reference expression data
Species Human Mouse
Entrez 7392 22282
Ensembl ENSG00000105698 ENSMUSG00000058239
UniProt Q15853 Q64705
RefSeq (mRNA) NM_003367 NM_011680
RefSeq (protein) NP_003358 NP_035810
Location (UCSC) Chr 19:
35.76 – 35.77 Mb
Chr 7:
30.95 – 30.96 Mb
PubMed search [1] [2]

Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.[1][2]

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]


USF2 has been shown to interact with USF1 (human gene),[3][4] PPRC1[5] and BRCA1.[6]


The USF2 gene is repressed by the microRNA miR-10a.[7]


  1. ^ Groenen PM, Garcia E, Debeer P, Devriendt K, Fryns JP, Van de Ven WJ (Mar 1997). "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia". Genomics 38 (2): 141–8. doi:10.1006/geno.1996.0609. PMID 8954795. 
  2. ^ a b "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting". 
  3. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ Viollet, B; Lefrançois-Martinez A M; Henrion A; Kahn A; Raymondjean M; Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". J. Biol. Chem. (UNITED STATES) 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. ISSN 0021-9258. PMID 8576131. 
  5. ^ Moore, Meredith L; Park Edwards A; McMillin Jeanie B (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". J. Biol. Chem. (United States) 278 (19): 17263–8. doi:10.1074/jbc.M210486200. ISSN 0021-9258. PMID 12611894. 
  6. ^ Cable, P LouAnn; Wilson Cindy A; Calzone Frank J; Rauscher Frank J; Scully Ralph; Livingston David M; Li Leping; Blackwell Courtney B; Futreal P Andrew; Afshari Cynthia A (Oct 2003). "Novel consensus DNA-binding sequence for BRCA1 protein complexes". Mol. Carcinog. (United States) 38 (2): 85–96. doi:10.1002/mc.10148. ISSN 0899-1987. PMID 14502648. 
  7. ^ Agirre X, Jiménez-Velasco A, San José-Enériz E, Garate L, Bandrés E, Cordeu L et al. (2008). "Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth.". Mol Cancer Res 6 (12): 1830–40. doi:10.1158/1541-7786.MCR-08-0167. PMID 19074828. 

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