The 1872 South Carolina United States House of Representatives elections were held on November 5, 1872 to select five Representatives for two-year terms from the state of South Carolina. The three incumbents who ran were re-elected and the two open seats were retained by the Republicans. The composition of the state delegation thus remained solely Republican.
The state unsuccessfully applied to have a fifth member seated in 1871 in the House of Representatives. Following apportionment from the 1870 census, the state was granted an extra seat and an At-large election was used to decide the fifth member. Republican Richard H. Cain defeated Independent Republican L.E. Johnson in the election and became the only member from South Carolina to be elected from an At-large district.
"Report of the Secretary of State to the General Assembly of South Carolina." Reports and Resolutions of the General Assembly of the State of South Carolina at the Regular Session, 1871-'72. Columbia, SC: Republican Printing Company, 1872, pp. 62, 64-67.