In January 2007, a four month undercover investigation resulted in at least 15 arrests of students from University City and Patrick Henry High School. Authorities confiscated Marijuana, Ecstasy, psychedelic mushrooms, and Prescription Medication. There have been multiple other busts like this one at University City High School.
UCHS offers a wide range of instructional programs. The Advanced Placement Program, Gifted and Talented Education (GATE) Program, the seminar program, and the special education program address the needs of identified students. UCHS students have the opportunity to take visual and performing arts courses and practical arts courses.
The school offers 15 AP classes: Biology, Chemistry, Environmental Science, Physics (alternating years with B and C), Statistics, US Government, US History, World History, English Language and Composition, English Literature and Composition, Art History, Studio Art, Psychology, French Language, and Spanish Language. The school also participates in the Accelerated College Program with San Diego Mesa College to offer Calculus, Linear Algebra, Discrete Mathematics, and Political Science. These classes are taught by Mesa College professors on the University City High School campus.
The color palette of the school as well as their three primary logos, the UC Script, the Centurion, and the UC block logo are given below. The block logo is used as the "Varsity Letter" style for all varsity letter-earning athletes.