Urocortin

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Urocortin
Protein UCN PDB 2RMF.png
Rendering based on PDB 2RMF.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UCN ; UI; UROC
External IDs OMIM600945 MGI1276123 HomoloGene2515 GeneCards: UCN Gene
RNA expression pattern
PBB GE MPV17 206072 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7349 22226
Ensembl ENSG00000163794 ENSMUSG00000038676
UniProt P55089 P81615
RefSeq (mRNA) NM_003353 NM_021290
RefSeq (protein) NP_003344 NP_067265
Location (UCSC) Chr 2:
27.53 – 27.53 Mb
Chr 5:
31.14 – 31.14 Mb
PubMed search [1] [2]

Urocortin is a protein that in humans is encoded by the UCN gene.[1][2][3] This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain, it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[3] Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor (CRF) family that includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is also a potent and long-lasting hypotensive agent and increases coronary blood flow.

Interactions[edit]

Urocortin has been shown to interact with Corticotropin releasing hormone receptor 1.[4][5]

References[edit]

  1. ^ Zhao L, Donaldson CJ, Smith GW, Vale WW (April 1999). "The structures of the mouse and human urocortin genes (Ucn and UCN)". Genomics 50 (1): 23–33. doi:10.1006/geno.1998.5292. PMID 9628819. 
  2. ^ Tsarev OB (July 1977). "[Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks]". Biofizika 22 (2): 197–200. PMID 861256. 
  3. ^ a b "Entrez Gene: UCN urocortin". 
  4. ^ Donaldson, C J; Sutton S W, Perrin M H, Corrigan A Z, Lewis K A, Rivier J E, Vaughan J M, Vale W W (May 1996). "Cloning and characterization of human urocortin". Endocrinology (UNITED STATES) 137 (5): 2167–70. doi:10.1210/en.137.5.2167. ISSN 0013-7227. PMID 8612563. 
  5. ^ Gottowik, J; Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc R G, Moreau J L, Monsma F J, Kilpatrick G J (October 1997). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin". Neuropharmacology (ENGLAND) 36 (10): 1439–46. doi:10.1016/S0028-3908(97)00098-1. ISSN 0028-3908. PMID 9423932. 

Further reading[edit]