Urocortin

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Urocortin
Protein UCN PDB 2RMF.png
Rendering based on PDB 2RMF.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UCN ; UI; UROC
External IDs OMIM600945 MGI1276123 HomoloGene2515 GeneCards: UCN Gene
RNA expression pattern
PBB GE MPV17 206072 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7349 22226
Ensembl ENSG00000163794 ENSMUSG00000038676
UniProt P55089 P81615
RefSeq (mRNA) NM_003353 NM_021290
RefSeq (protein) NP_003344 NP_067265
Location (UCSC) Chr 2:
27.53 – 27.53 Mb
Chr 5:
31.14 – 31.14 Mb
PubMed search [1] [2]

Urocortin is a protein that in humans is encoded by the UCN gene.[1][2][3]

Function[edit]

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain, it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[3]

Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor (CRF) family that includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is also a potent and long-lasting hypotensive agent and increases coronary blood flow.

Interactions[edit]

Urocortin has been shown to interact with Corticotropin releasing hormone receptor 1.[4][5]

References[edit]

  1. ^ Zhao L, Donaldson CJ, Smith GW, Vale WW (April 1999). "The structures of the mouse and human urocortin genes (Ucn and UCN)". Genomics 50 (1): 23–33. doi:10.1006/geno.1998.5292. PMID 9628819. 
  2. ^ Tsarev OB (July 1977). "[Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks]". Biofizika 22 (2): 197–200. PMID 861256. 
  3. ^ a b "Entrez Gene: UCN urocortin". 
  4. ^ Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE et al. (May 1996). "Cloning and characterization of human urocortin". Endocrinology 137 (5): 2167–70. doi:10.1210/en.137.5.2167. PMID 8612563. 
  5. ^ Gottowik J, Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc RG et al. (October 1997). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin". Neuropharmacology 36 (10): 1439–46. doi:10.1016/S0028-3908(97)00098-1. PMID 9423932. 

Further reading[edit]

  • Inui, Bowers, et al. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004 Mar;18(3):439-56. doi:[//dx.doi.org/10.1096%2Ffj.03-0641rev 10.1096/fj.03-0641rev PMID 15003990]
  • Huang Y, Yao XQ, Lau CW, Chan YC, Tsang SY, Chan FL. Urocortin and cardiovascular protection. Acta Pharmacol Sin. 2004 Mar;25(3):257-65.
  • Takahashi, Kazuhiro. Translational medicine in fish-derived peptides: From fish endocrinology to human physiology and diseases. Endocrine Journal (Kyoto, Japan) (2004), 51(1), 1-17.
  • Adachi T, Schamel WW, Kim KM, Watanabe T, Becker B, Nielsen PJ et al. (1996). "The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence.". EMBO J. 15 (7): 1534–41. PMC 450061. PMID 8612576. 
  • Iino K, Sasano H, Oki Y, Andoh N, Shin RW, Kitamoto T et al. (1997). "Urocortin expression in human pituitary gland and pituitary adenoma.". J. Clin. Endocrinol. Metab. 82 (11): 3842–50. doi:10.1210/jc.82.11.3842. PMID 9360550. 
  • Gottowik J, Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc RG et al. (1998). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin.". Neuropharmacology 36 (10): 1439–46. doi:10.1016/S0028-3908(97)00098-1. PMID 9423932. 
  • Bamberger CM, Wald M, Bamberger AM, Ergün S, Beil FU, Schulte HM (1998). "Human lymphocytes produce urocortin, but not corticotropin-releasing hormone.". J. Clin. Endocrinol. Metab. 83 (2): 708–11. doi:10.1210/jc.83.2.708. PMID 9467598. 
  • Takahashi K, Totsune K, Sone M, Murakami O, Satoh F, Arihara Z et al. (1998). "Regional distribution of urocortin-like immunoreactivity and expression of urocortin mRNA in the human brain.". Peptides 19 (4): 643–7. doi:10.1016/S0196-9781(98)00012-6. PMID 9622018. 
  • Iino K, Sasano H, Oki Y, Andoh N, Shin RW, Kitamoto T et al. (1999). "Urocortin expression in the human central nervous system.". Clin. Endocrinol. (Oxf) 50 (1): 107–14. doi:10.1046/j.1365-2265.1999.00624.x. PMID 10341863. 
  • Watanabe F, Oki Y, Ozawa M, Masuzawa M, Iwabuchi M, Yoshimi T et al. (1999). "Urocortin in human placenta and maternal plasma.". Peptides 20 (2): 205–9. doi:10.1016/S0196-9781(98)00175-2. PMID 10422876. 
  • Slominski A, Roloff B, Curry J, Dahiya M, Szczesniewski A, Wortsman J (2000). "The skin produces urocortin.". J. Clin. Endocrinol. Metab. 85 (2): 815–23. doi:10.1210/jc.85.2.815. PMID 10690896. 
  • Muramatsu Y, Fukushima K, Iino K, Totsune K, Takahashi K, Suzuki T et al. (2001). "Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa.". Peptides 21 (12): 1799–809. doi:10.1016/S0196-9781(00)00335-1. PMID 11150640. 
  • Muramatsu Y, Sugino N, Suzuki T, Totsune K, Takahashi K, Tashiro A et al. (2001). "Urocortin and corticotropin-releasing factor receptor expression in normal cycling human ovaries.". J. Clin. Endocrinol. Metab. 86 (3): 1362–9. doi:10.1210/jc.86.3.1362. PMID 11238533. 
  • Hsu SY, Hsueh AJ (2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.". Nat. Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. 
  • Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224. 
  • Kimura Y, Takahashi K, Totsune K, Muramatsu Y, Kaneko C, Darnel AD et al. (2002). "Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart.". J. Clin. Endocrinol. Metab. 87 (1): 340–6. doi:10.1210/jc.87.1.340. PMID 11788672. 
  • Florio P, Arcuri F, Ciarmela P, Runci Y, Romagnoli R, Cintorino M et al. (2002). "Identification of urocortin mRNA and peptide in the human endometrium.". J. Endocrinol. 173 (2): R9–14. doi:10.1677/joe.0.173R009. PMID 12010647. 
  • Arcuri F, Cintorino M, Florio P, Floccari F, Pergola L, Romagnoli R et al. (2002). "Expression of urocortin mRNA and peptide in the human prostate and in prostatic adenocarcinoma.". Prostate 52 (3): 167–72. doi:10.1002/pros.10094. PMID 12111693. 
  • Ikeda K, Tojo K, Oki Y, Nakao K (2002). "Urocortin has cell-proliferative effects on cardiac non-myocytes.". Life Sci. 71 (16): 1929–38. doi:10.1016/S0024-3205(02)01945-8. PMID 12175707.