Corticotropin releasing hormone receptor 2

Corticotropin releasing hormone receptor 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3N93, 3N95, 3N96
Identifiers
Symbols	CRHR2; CRF-RB; CRF2; CRFR2; HM-CRF
External IDs	OMIM: 602034 MGI: 894312 HomoloGene: 55612 IUPHAR: CRF2 ChEMBL: 4069 GeneCards: CRHR2 Gene
Gene Ontology Molecular function • hormone activity • protein binding • corticotrophin-releasing factor receptor activity Cellular component • endoplasmic reticulum • Golgi apparatus • plasma membrane • integral to plasma membrane • cell surface Biological process • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • negative regulation of angiogenesis • positive regulation of cAMP-mediated signaling • negative regulation of cAMP-mediated signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1395	12922
Ensembl	ENSG00000106113	ENSMUSG00000003476
UniProt	Q13324	Q60748
RefSeq (mRNA)	NM_001202475	NM_009953
RefSeq (protein)	NP_001189404	NP_034083
Location (UCSC)	Chr 7: 30.69 – 30.74 Mb	Chr 6: 55.09 – 55.13 Mb
PubMed search	[1]	[2]

Corticotropin releasing hormone receptor 2 (CRHR2) is a human protein, also known as CRF₂, with CRF₂ now being the IUPHAR-recommended name.

See also

• Corticotropin releasing hormone receptor

Further reading

• Perrin MH, Donaldson CJ, Chen R, et al. (1994). "Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor.". Endocrinology 133 (6): 3058–61. doi:10.1210/en.133.6.3058. PMID 8243338. 
• Liaw CW, Lovenberg TW, Barry G, et al. (1996). "Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.". Endocrinology 137 (1): 72–7. doi:10.1210/en.137.1.72. PMID 8536644. 
• Donaldson CJ, Sutton SW, Perrin MH, et al. (1996). "Cloning and characterization of human urocortin.". Endocrinology 137 (5): 2167–70. doi:10.1210/en.137.5.2167. PMID 8612563. 
• Meyer AH, Ullmer C, Schmuck K, et al. (1997). "Localization of the human CRF2 receptor to 7p21-p15 by radiation hybrid mapping and FISH analysis.". Genomics 40 (1): 189–90. doi:10.1006/geno.1996.4521. PMID 9070940. 
• Valdenaire O, Giller T, Breu V, et al. (1997). "A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor.". Biochim. Biophys. Acta 1352 (2): 129–32. PMID 9199241. 
• Gottowik J, Goetschy V, Henriot S, et al. (1998). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin.". Neuropharmacology 36 (10): 1439–46. doi:10.1016/S0028-3908(97)00098-1. PMID 9423932. 
• Kostich WA, Chen A, Sperle K, Largent BL (1998). "Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor.". Mol. Endocrinol. 12 (8): 1077–85. doi:10.1210/me.12.8.1077. PMID 9717834. 
• Willenberg HS, Bornstein SR, Hiroi N, et al. (2000). "Effects of a novel corticotropin-releasing-hormone receptor type I antagonist on human adrenal function.". Mol. Psychiatry 5 (2): 137–41. doi:10.1038/sj.mp.4000720. PMID 10822340. 
• Reyes TM, Lewis K, Perrin MH, et al. (2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2843–8. doi:10.1073/pnas.051626398. PMC 30227. PMID 11226328. 
• Hsu SY, Hsueh AJ (2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.". Nat. Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. 
• Lewis K, Li C, Perrin MH, et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. 
• Wetzka B, Sehringer B, Schäfer WR, et al. (2004). "Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term.". Exp. Clin. Endocrinol. Diabetes 111 (3): 154–61. doi:10.1055/s-2003-39778. PMID 12784189. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Karteris E, Hillhouse EW, Grammatopoulos D (2004). "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility.". Endocrinology 145 (2): 890–900. doi:10.1210/en.2003-1210. PMID 14592950. 
• Seres J, Bornstein SR, Seres P, et al. (2004). "Corticotropin-releasing hormone system in human adipose tissue.". J. Clin. Endocrinol. Metab. 89 (2): 965–70. doi:10.1210/jc.2003-031299. PMID 14764822. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Nanda SA, Roseboom PH, Nash GA, et al. (2004). "Characterization of the human corticotropin-releasing factor2(a) receptor promoter: regulation by glucocorticoids and the cyclic adenosine 5'-monophosphate pathway.". Endocrinology 145 (12): 5605–15. doi:10.1210/en.2004-0907. PMID 15331578. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 

External links

• "Corticotropin-releasing Factor Receptors: CRF₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• Corticotropin-releasing hormone receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.