User:Mr. Ibrahem/Selegiline
Clinical data | |
---|---|
Pronunciation | /səˈlɛdʒɪliːn/ sə-LEJ-i-leen |
Trade names | Eldepryl, Jumex, Zelapar, Emsam, others[1] |
Other names | L-Deprenyl; (R)-(–)-N,α-Dimethyl-N-2-propynylphenethylamine; (R)-(–)-N-Methyl-N-2-propynylamphetamine; (R)-(–)-N-2-propynylmethamphetamine |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697046 |
License data |
|
Pregnancy category |
|
Routes of administration | By mouth, skin (patch) |
Drug class | Monoamine oxidase inhibitor[2] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 10% (by mouth), 73% (patch) |
Protein binding | 94% |
Metabolism | Intestines and liver |
Metabolites | N-Desmethylselegiline, levoamphetamine, levomethamphetamine |
Elimination half-life | 1.5–3.5 hours (oral),[3] 18–25 hours (transdermal)[4] |
Excretion | Urine |
Identifiers | |
| |
Chemical and physical data | |
Formula | C13H17N |
Molar mass | 187.281 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Selegiline, sold under the brand names Eldepryl among others, is a medication used to treat parkinsonism including in Parkinson's disease and major depressive disorder.[5][2][6] It is used by mouth or as a patch applied to skin.[2][6]
When taken by mouth, common side effects include nausea, lightheadedness, dry mouth, headache, and hallucinations.[5] When applied as a patch, common side effects include trouble sleeping, rash, and a stuffy nose.[6] Other side effects may include serotonin syndrome, low blood pressure, urge to gamble, neuroleptic malignant syndrome, and sudden onset of sleep.[5] It is a monoamine oxidase B inhibitor at lower doses, while at higher doses it is also a monoamine oxidase A inhibitor.[2][5] It works by increasing brain levels of dopamine and serotonin.[6][5]
Selegilinewas approved for medical use in the United States in 1989.[5] In the United Kingdom 100 tablets of 10 mg costs the NHS about £32 as of 2021.[2] This amount in the United States costs about 130 USD.[7] In the United States a month of patches costs about 1,800 USD.[8]
References[edit]
- ^ "Selegiline". Drugs.com. Archived from the original on December 29, 2019. Retrieved February 7, 2016.
- ^ a b c d e f BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 447. ISBN 978-0-85711-369-6.
- ^ "Archive copy". Archived from the original on April 16, 2015. Retrieved July 10, 2021.
{{cite web}}
: CS1 maint: archived copy as title (link) - ^ "Archive copy" (PDF). Archived (PDF) from the original on April 3, 2021. Retrieved July 10, 2021.
{{cite web}}
: CS1 maint: archived copy as title (link) - ^ a b c d e f g h "Selegiline Monograph for Professionals". Drugs.com. Archived from the original on August 13, 2020. Retrieved October 11, 2021.
- ^ a b c d e "EMSAM® (selegiline transdermal system)" (PDF). Archived (PDF) from the original on August 10, 2021. Retrieved October 11, 2021.
- ^ "Selegiline Prices and Selegiline Coupons - GoodRx". GoodRx. Retrieved October 11, 2021.
- ^ "Emsam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on November 15, 2016. Retrieved October 11, 2021.