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Vav 3 guanine nucleotide exchange factor
Protein VAV3 PDB 2d86.png
PDB rendering based on 2d86.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols VAV3 ; FLJ40431
External IDs OMIM605541 MGI1888518 HomoloGene38143 GeneCards: VAV3 Gene
RNA expression pattern
PBB GE VAV3 218807 at tn.png
PBB GE VAV3 218806 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10451 57257
Ensembl ENSG00000134215 ENSMUSG00000033721
UniProt Q9UKW4 Q9R0C8
RefSeq (mRNA) NM_001079874 NM_020505
RefSeq (protein) NP_001073343 NP_065251
Location (UCSC) Chr 1:
108.11 – 108.51 Mb
Chr 3:
109.34 – 109.69 Mb
PubMed search [1] [2]

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.[1]

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]


VAV3 has been shown to interact with Grb2.[2][3]


  1. ^ a b "Entrez Gene: VAV3 vav 3 oncogene". 
  2. ^ Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. (United States) 21 (3): 315–318. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. 
  3. ^ Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (December 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. (UNITED STATES) 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN 0270-7306. PMC 102179. PMID 11094073. 

Further reading[edit]