Vitamin D-binding protein

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Group-specific component (vitamin D binding protein)
Protein GC PDB 1j78.png
Crystallographic structure of the human vitamin D-binding protein.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GC ; DBP; DBP/GC; GRD3; HEL-S-51; VDBG; VDBP
External IDs OMIM139200 MGI95669 HomoloGene486 ChEMBL: 2259 GeneCards: GC Gene
EC number 6.4.-.-
RNA expression pattern
PBB GE GC 204965 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2638 14473
Ensembl ENSG00000145321 ENSMUSG00000035540
UniProt P02774 P21614
RefSeq (mRNA) NM_000583 NM_008096
RefSeq (protein) NP_000574 NP_032122
Location (UCSC) Chr 4:
72.61 – 72.67 Mb
Chr 5:
89.42 – 89.46 Mb
PubMed search [1] [2]

Vitamin D-binding protein, also known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene.[2][3]

Function[edit]

Vitamin D-binding protein belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues.[3] As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells.[4]

Structure[edit]

Human GC is a glycosylated alpha-globulin, ~58 kDa in size. Its 458 amino acids are coded for by 1690 nucleotides on chromosome 4 (4q11–q13). The primary structure contains 28 cysteine residues forming multiple disulfide bonds. GC contains 3 domains. Domain 1 is composed of 10 alpha helices, domain 2 of 9, and domain 3 of 4.[1]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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VitaminDSynthesis_WP1531 Go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article go to article go to article go to article Go to article go to article
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Vitamin D Synthesis Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531". 

References[edit]

  1. ^ a b PDB 1J78; Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C (February 2002). "A structural basis for the unique binding features of the human vitamin D-binding protein". Nat. Struct. Biol. 9 (2): 131–6. doi:10.1038/nsb754. PMID 11799400. 
  2. ^ Mikkelsen M, Jacobsen P, Henningsen K (Jul 1977). "Possible localization of Gc-System on chromosome 4. Loss of long arm 4 material associated with father-child incompatibility within the Gc-System". Hum Hered 27 (2): 105–7. doi:10.1159/000152857. PMID 558959. 
  3. ^ a b "Entrez Gene: GC group-specific component (vitamin D binding protein)". 
  4. ^ Yamamoto N, Suyama H, Yamamoto N (2008). "Immunotherapy for Prostate Cancer with Gc Protein-Derived Macrophage-Activating Factor, GcMAF" ([PDF]). TRANSLATIONAL ONCOLOGY 1 (2): 65–72. PMC 2510818. PMID 18633461. 

Further reading[edit]