Wesley College first open its doors in June 1882 offering secondary education in Belize. The school opened with only five boys, the principal was Reverend T.N. Roberts and the school was located on Albert Street, in Belize City. In 1950 girls were able to attend the college.
The school opened a music education center on 19 October 2006 at a cost of BZ$.5 million. The center offers lessons to students as well as community members.