Talk:Heparin/GA1

GA Reassessment

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Starting GA reassessment as part of the GA Sweeps process. Jezhotwells (talk) 19:38, 27 February 2010 (UTC)

Checking against GA criteria

This article has been reviewed as part of Wikipedia:WikiProject Good articles/Project quality task force in an effort to ensure all listed Good articles continue to meet the Good article criteria. In reviewing the article, I have found there are some issues that may need to be addressed, listed below. I will check back in three days. If these issues are addressed, the article will remain listed as a Good article. Otherwise, it may be delisted (such a decision may be challenged through WP:GAR). If improved after it has been delisted, it may be nominated at WP:GAN. Feel free to drop a message on my talk page if you have any questions, and many thanks for all the hard work that has gone into this article thus far.

GA review (see here for criteria)

1. It is reasonably well written.

   a (prose): b (MoS):

   The article appears to contain copyright violations such as:

   The most common disaccharide unit is composed of a 2-O-sulfated iduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S) from {http://www.medic8.com/medicines/Panheprin.html}

   Under physiological conditions, the ester and amide sulfate groups are deprotonated and attract positively-charged counterions to form a heparin salt. from {http://www.medic8.com/medicines/Panheprin.html}

   The three-dimensional structure of heparin is complicated by the fact that iduronic acid may be present in either of two low-energy conformations when internally positioned within an oligosaccharide from {http://www.medic8.com/medicines/Calciparine.html}

   Heparin is a naturally-occurring anticoagulant produced by basophils and mast cells.[10] Heparin acts as an anticoagulant, preventing the formation of clots and extension of existing clots within the blood. from {http://www.medic8.com/medicines/Panheprin.html}

   Danaparoid, a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate, can be used as an anticoagulant in patients that have developed HIT. Because danaparoid does not contain heparin or heparin fragments, cross-reactivity of danaparoid with heparin-induced antibodies is reported as less than 10% from {http://www.medic8.com/medicines/Panheprin.html}

   A serious side-effect of heparin is heparin-induced thrombocytopenia (HIT). HIT is caused by an immunological reaction that makes platelets a target of immunological response, resulting in the degradation of platelets from {http://www.heparin-law.com/adverse_heparin_reactions.html}

   Heparin is one of the oldest drugs currently still in widespread clinical use. Its discovery in 1916 predates the establishment of the Food and Drug Administration of the United States, although it did not enter clinical trials until 1935. from {http://newjournal.kcsnet.or.kr/main/j_search/j_download.htm?code=B091242}

   The enzymes traditionally used to digest heparin or HS are naturally produced by the soil bacterium Pedobacter heparinus (formerly named Flavobacterium heparinum). from {http://stanford.wellsphere.com/wellmix360/pedobacter}

   http://en.wikipedia.org/w/index.php?title=Anhydromannose&action=edit&redlink=1 from {http://www.boinc.org/heparin-sodium/}

   None of these sites shows a GFDL or Commons type licence. All but boinc.com show copyright notices. As a result of this I am going to immediately de-list this artcile. I have not examined every phrase, but it appears that there is little in the article that is copyuright free.

2. It is factually accurate and verifiable.

   a (references): b (citations to reliable sources): c (OR):

3. It is broad in its coverage.

   a (major aspects): b (focused):

4. It follows the neutral point of view policy.

   Fair representation without bias:

5. It is stable.

   No edit wars, etc.:

6. It is illustrated by images, where possible and appropriate.

   a (images are tagged and non-free images have fair use rationales): b (appropriate use with suitable captions):

7. Overall:

   Pass/Fail:

   The copyright concerns listed above are sufficient for immediate de-listing. However I will notify major contributors and projects for a response. On hold for three days. Jezhotwells (talk) 20:06, 27 February 2010 (UTC)

Copyvio concerns

After running the Copyright Violation Detector tool (output below; original job run here) I'm beginning to suspect the copyvio is the other direction (i.e. non-free use of Wikipedia material):

CVD output

Output of Copyright Violation Detector (3/2/2010):

Heparin

• Heparin, a highly-sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological...

• http://www.alibaba.com/product-gs/239372546/Heparins.html (55 KB)
• http://www.boinc.org/heparin/ (58 KB)
• http://www.kidneyfun.net/lofiversion/index.php?t5634.html (129 bytes)
• http://www.news-medical.net/?tag=/Heparin (48 KB)
• http://www.online-internet-drugstore-pharmacy.com/heparin.html (27/3/2009; 17 KB)
• http://www.youhaverights.com/legal_updates/read/contaminated-heparin-may-still-be-in-use-fda/ (24 KB)

• molecule. It can also be used to form an inner anticoagulant surface on various experimental and medical devices such as test tubes...

• http://answers.yahoo.com/question/index?qid=20070911125223AAiPsFX (40 KB)
• http://sciphar.en.alibaba.com/product/239382423-200391973/Heparin.html (8/2/2010; 49 KB)
• http://www.alibaba.com/product-gs/239372546/Heparins.html
• http://www.boinc.org/heparin/
• http://www.news-medical.net/?tag=/Heparin (48 KB)
• http://www.online-internet-drugstore-pharmacy.com/heparin.html (27/3/2009; 17 KB)

• and renal dialysis machines. Pharmaceutical grade heparin is derived from mucosal tissues of slaughtered meat animals such as porcine (pig) intestine or...

• http://www.boinc.org/heparin/
• http://www.news-medical.net/?tag=/Heparin (48 KB)

• Although used principally in medicine for anticoagulation, the true physiological role in the body remains unclear, because blood anti-coagulation is achieved mostly...

• http://www.alibaba.com/product-gs/245958902/Heparin_Lithium.html (59 KB)
• http://www.boinc.org/heparin/
• http://www.portalfitness.tv/0/tag/contimination.html (39 KB)
• http://www.seniorfitness.com/ArticleSearch.cfm?Linkphrase=heparin (33 KB)

• into the vasculature at sites of tissue injury. It has been proposed that, rather than anticoagulation, the main purpose of heparin is...

• http://www.boinc.org/heparin/
• http://www.online-internet-drugstore-pharmacy.com/heparin.html (27/3/2009; 17 KB)
• http://www.seniorfitness.com/ArticleSearch.cfm?Linkphrase=heparin
• Native heparin is a polymer with a molecular weight ranging from 3 kDa to 50 kDa, although the average molecular weight of...
• http://www.boinc.org/heparin/
• http://www.seniorfitness.com/ArticleSearch.cfm?Linkphrase=heparin

• Heparin is a member of the glycosaminoglycan family of carbohydrates (which includes the closely-related molecule heparan sulfate) and consists of a variably-sulfated...

• http://www.boinc.org/heparin/
• http://www.faqs.org/patents/app/20090263420 (432 KB)
• http://www.medic8.com/medicines/Calciparine.html (19 KB)
• http://www.medic8.com/medicines/Heparin-sodium.html (11 KB)
• http://www.online-internet-drugstore-pharmacy.com/heparin.html (27/3/2009; 17 KB)
• http://www.seniorfitness.com/ArticleSearch.cfm?Linkphrase=heparin

• The main disaccharide units that occur in heparin are shown below. The most common disaccharide unit is composed of a 2-O-sulfated iduronic...

• http://www.boinc.org/heparin/
• http://www.medic8.com/medicines/Calciparine.html
• http://www.medic8.com/medicines/Heparin-sodium.html
• http://www.online-internet-drugstore-pharmacy.com/heparin.html (27/3/2009; 17 KB)
• http://www.seniorfitness.com/ArticleSearch.cfm?Linkphrase=heparin

• ester and amide sulfate groups are deprotonated and attract positively-charged counterions to form a heparin salt. It is in this form that...

• http://www.boinc.org/heparin/
• http://www.medic8.com/medicines/Calciparine.html
• http://www.medic8.com/medicines/Heparin-sodium.html
• http://www.netipedia.com/index.php/Heparin (28/4/2006; 27 KB)
• http://www.online-internet-drugstore-pharmacy.com/heparin.html (27/3/2009; 17 KB)
• http://www.seniorfitness.com/ArticleSearch.cfm?Linkphrase=heparin

• One unit of heparin (the "Howell Unit") is an amount approximately equivalent to 0.002 mg of pure heparin, which is the quantity required...

• http://www.boinc.org/heparin/

• The three-dimensional structure of heparin is complicated by the fact that iduronic acid may be present in either of two low-energy conformations...

• http://www.boinc.org/heparin/
• http://www.medic8.com/medicines/Calciparine.html
• http://www.online-internet-drugstore-pharmacy.com/heparin.html (27/3/2009; 17 KB)

In particular

• The hanging chemical names (without the corresponding images) on the Medic8.com page seem suspicious (also an issue on the boinc.com version of the same page);
• The phrase "Heparin is one of the oldest drugs currently still in widespread clinical use. Its discovery in 1916 predates the establishment of the United States Food and Drug Administration, although it did not enter clinical trials until 1935." has been in the Wikipedia version since at least 2008-06-11 (per this version), while the Bulletin of the Korean Chemical Sociey paper is listed as having been received 2009-05-31;

• The above is also true for this link dated 2008-10-14;

• Refreshingly, the Wellsphere link actually does cite Wikipedia (go figure);

There are other links I didn't follow, but given the above I suspect we have a whole host of sites (and at least one academic paper!) blatantly ripping-off WP content. -- MarcoTolo (talk) 22:47, 2 March 2010 (UTC)