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specific for tumor antigens. Therefore, the strategy in using immunological checkpoints in cancer therapy is to inhibit inhibitory molecules of the immune...

response to an immunologic stimulus. Some cancers can protect themselves from attack by stimulating immune checkpoint targets. Checkpoint therapy can block...

intrinsic immunologic checkpoints with the potential to enhance adoptive immunotherapies. Many cancer patients do not respond to immune checkpoint blockade...

Cancers Led by John M. Maris, Crystal L. Mackall SU2C-CRI Dream Team: Immunologic Checkpoint Blockade and Adoptive Cell Transfer in Cancer Therapy Led by James...

protect themselves from attack by stimulating immune checkpoint targets. Inhibitory checkpoint molecules are targets for cancer immunotherapy due to...

purported target. Thus CISH represents a new class of T-cell intrinsic immunologic checkpoints with the potential to enhance adoptive immunotherapies. Neither...

Immune tolerance, also known as immunological tolerance or immunotolerance, refers to the immune system's state of unresponsiveness to substances or tissues...

inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PDL1 immune checkpoint proteins present on the surface...

(Trichuris suis) and hookworm (Necator americanus) have been tested for immunological diseases and allergies, and have proved beneficial on multiple fronts...

infections and cancer. His discoveries include characterizing several immunological checkpoints and T cell states that can be targeted to re-invigorate exhausted...

The Immunologic Constant of Rejection (ICR), is a notion introduced by biologists to group a shared set of genes expressed in tissue destructive-pathogenic...

pathogens more efficiently. Adaptive (or acquired) immunity creates an immunological memory leading to an enhanced response to subsequent encounters with...

molecules were engineered to remove immunogenic content and to increase immunologic efficiency. This was initially achieved by the production of chimeric...

from 2013 to 2016. She is the co-director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women's Hospital....

programmed cell death protein 1 (PD-1) monoclonal antibody that acts as a checkpoint inhibitor. In 2018, toripalimab was approved in China for the treatment...

[citation needed] Paraneoplastic neurological syndromes may be related immune checkpoint inhibitors (ICIs), one of the underlying causes in inflammatory central...

checkpoint inhibitor, ipilimumab (Yervoy), had shown strong promise in treating metastatic melanoma and that a second Bristol Myers Squibb checkpoint...

become the gold standard in cancer treatment of all stages of disease. Immunological effects resulting from the cryoablation of tumors was first observed...

prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes...

Antinuclear antibody test positive; sensitivity = 99%; specificity = 49%. Immunologic disorder: Positive anti-Smith, anti-ds DNA, antiphospholipid antibody...