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Sleeping disorders following traumatic brain injury

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Sleep disorder is a common repercussion of traumatic brain injury (TBI).[1][2] It occurs in 30%-70% of patients with TBI.[1][2] TBI can be distinguished into two categories, primary and secondary damage. Primary damage includes injuries of white matter, focal contusion, cerebral edema and hematomas,[3] mostly occurring at the moment of the trauma. Secondary damage involves the damage of neurotransmitter release, inflammatory responses, mitochondrial dysfunctions and gene activation,[3] occurring minutes to days following the trauma. Patients with sleeping disorders following TBI specifically develop insomnia, sleep apnea, narcolepsy, periodic limb movement disorder and hypersomnia.[1][3][4] Furthermore, circadian sleep-wake disorders can occur after TBI.[1][3][5]

Presentation

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Consequences

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Increased level of anxiety and depression is associated with higher levels of sleep disturbances in TBI patients.[5][6] If depression or anxiety are not treated in these patients, successful treatment of sleep may be prevented.[7] TBI patients with sleepiness show impaired cognitive function and vigilance performance which impairs daily functioning.[8] Sleep is known for its neuroprotective role by elimination of neurotoxic waste products, the neural growth and plasticity, but furthermore, for a specific neuroplastic recovery effect from post mild TBI symptoms.[9] Therefore, sleep disturbance may have a negative effect on injury recovery, rehabilitation and outcomes, leading to long term disabilities.[3][4][5][9] This may be related to less non-REM sleep due to a higher amount of stage 1 sleep.[3][10] TBI patients with obstructive sleep apnea show reduced cardiac function and hypertension.[11] Obstructive sleep apnea is also associated with structural changes in the brain.[11]

Indirect consequences of sleep disorders after TBI can be the exacerbation of the many complications and comorbidities of TBI.[9] These include fatigue, post-traumatic stress symptoms or post-traumatic stress disorder (PTSD) and chronic pain.[9][7]

Animal studies with rodents showed that sleep deprivation after traumatic brain injury has been associated with multiple, potentially negative effects on brain homeostasis, including changes in glutamate concentration and energy consumption as well as in brain temperature.[12]

In summary, sleep disorders occurring in TBI patients are associated with a low health-related quality of life and a shorter survival status.[13][3][8][9]

Causes

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There are different kinds of TBI that cause different brain dysfunctions. Research suggests that TBI results in damage to sleep-regulation centers including the reticular activation system, specifically damage to the suprachiasmatic nuclei (SCN) which leads to disturbances in the circadian rhythm.[5] Considering hypersomnia, mostly areas involving the maintenance of wakefulness are damaged, such as the rostral pons, caudal midbrain and thalamus.[1]

Sleep disorders are more frequently reported when patients have mild TBI (mTBI).[1][3][5][14] Reasons for that could be the increased awareness of postinjury changes in mild TBI patients because they may be more determined to return to their preinjury life situation.[3][5] All age groups can be affected from sleep disorders after TBI, including children[1] and adolescents.[6]

There are several risk factors that are associated with occurring sleep disorders, such as lower years of education, severity of head injury and occurrence of residuals symptoms, for example headache or dizziness.[1]

Further neurodegeneration such as impaired neurotransmitter function, cerebrovascular autoregulatory dysfunction, neuroinflammation and dysregulation of circadian hormones such as melatonin and adenosine[15] can also be a consequence leading to sleep disturbances.[9]

Treatment

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In order to make a diagnosis, a subjective evaluation and objective sleep tests are assessed.[3][6] Subjective evaluations include self-report questionnaires and sleep diaries to assess the sleep pattern from the patient's perspective.[9] Objective sleep tests include mental and physical examinations and laboratory tests to test the medical background, such as Polysomnography (PSG) and Actigraphy.[9] It is typically not possible to assess these tests prior to an injury. Therefore, it is often not clear whether the sleeping disorder is a result of pre-existing disorders.[9] Careful assessment of patients and determining the nature of their sleeping disorder is essential for finding the most effective treatment.[9] It is also important to ensure that measures of sleep are appropriate for use in the stroke population. McLaren et al.[16] validated the Sleep Condition Indicator - a brief self-report measure of insomnia [17] - for use after stroke, and found the optimal diagnostic cut-off to be lower after stroke (≤13) than is conventional in the general population (≤16).

There is no explicit treatment for sleep disorders following TBI. Several interventions for general sleep disturbance have been tested in patients with TBI. In order to provide the proper treatment, it is best to divide the injury and its recovery in stages, given that the treatments differs in the different stages.[9] It has been seen how a deterioration of sleep quality during the subacute phase of mTBI has been linked with the worsening of behavioural, neuropsychiatric and somatic outcomes.[18][19] In general, treatment of sleep disorders following TBI can be distinguished in pharmacological and nonpharmacological interventions.

Pharmacological treatments

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Phototherapy

Pharmacological treatments have to be administered carefully. Some medication is highly addictive and the resulting withdrawal syndromes cause even more sleep disturbances, e.g. Insomnia.[13] Possible medications are Zopiclone and lorazepam, which have been proven effective in people with TBI.[3] Also Benzodiazepine hypnotics,[9] Benzodiazepine-receptor antagonists, antidepressants, psychostimulants[13] can be administered, especially in patients with insomnia. Some studies have shown negative effects of hypnotics, such as an increased risk of dementia.[9] In patients with hypersomnia, Modafinil, Armodafinil, Methylphenidate and amphetamines are often used as a treatment for day time sleepiness.[9] Medication should always be prescribed by an expert to make sure that the correct medicament is taken in an appropriate dose.

Nonpharmacological treatments

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Nonpharmacological treatments involve different interventions, starting with sleep hygiene,[13] which includes sleep promoting activities such as maintaining a regular and strict sleep schedule and avoiding heavy meals before bedtime in order to restore the natural sleep-wake cycle.[9] Further treatments options are phototherapy[13][3] and infrared light therapy,[9] which both, aim to treat circadian rhythm disorders such as delayed sleep phase disorder. Especially in patients with hypersomnia, bright light therapy in the morning has been proven to be effective.[9] A prolongation of slow-wave sleep increases glymphatic clearance of metabolic waste products, which can lead to improvements of sleep disorders.[9] Furthermore, studies showed ameliorated sleep pattern due to acupuncture[citation needed] of patients with TBI. Sleep apnea due to TBI can be treated through positive airway pressure,[9] which helps with the development of a regular breathing pattern during sleep and prevents waking up. Cognitive behavioral therapy for insomnia[6][9][13] also have been shown to effectively improve sleep in TBI patients. It aims to improve sleep habits and behaviors by identifying and changing the thoughts and the behaviors that affect the ability of a person to sleep or sleep well. The improvement of the quality of sleep and the decrease of depressive severity is associated with he use of near-infrared light for intracellular healing.[20]

Animal studies

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Animals studies showed that sleep deprivation prior to a brain injury might have healthy effects. Five days of complete sleep deprivation in rats before the traumatic brain injury, acted as protection against ischemic injury [21] and a habitual deceased in total amount of sleep time before TBI reduced the severity.[22]

There are several theories on the protectional effects of sleep disturbances before an injury in rats. Firstly, it may alter the pattern of gene activation and deactivation. This could lead to a higher degree of neuroprotection.[9] Lack of sleep might increase the levels of extracellular adenosine, which is also mostly neuroprotective against the TBI sequelae.[9] Furthermore, sleep deprivation might lead to a form of "ischemic precondition" which habituates the brain to the byproducts of a cellular injury.[9] Studies have been run to assess the role of caffeine in rats with sleeping disorders.[23] While results regarding rats studies have come out positive, in humans caffeine is believed to worsen sleep fragmentation and insomnia. Lastly insufficient quantity and quality of sleep may cause a rebound sleep post injury and increase the sleep enhanced regeneration and recovery.[9] More research is needed to investigate how these findings can be transferred to the treatment of humans with TBI.

References

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  1. ^ a b c d e f g h Viola-Saltzman M, Musleh C (2016-02-15). "Traumatic brain injury-induced sleep disorders". Neuropsychiatric Disease and Treatment. 12: 339–48. doi:10.2147/NDT.S69105. PMC 4760657. PMID 26929626.
  2. ^ a b Castriotta RJ, Murthy JN (March 2011). "Sleep disorders in patients with traumatic brain injury: a review". CNS Drugs. 25 (3): 175–85. doi:10.2165/11584870-000000000-00000. PMID 21062105. S2CID 35673846.
  3. ^ a b c d e f g h i j k l Rao V, Neubauer D, Vaishnavi S (September 2015). "Sleep Disturbances After Traumatic Brain Injury". Psychiatric Times. 32 (9).
  4. ^ a b Mazwi NL, Fusco H, Zafonte R (2015). "Sleep in traumatic brain injury". Traumatic Brain Injury, Part II. Handbook of Clinical Neurology. Vol. 128. pp. 553–66. doi:10.1016/B978-0-444-63521-1.00035-2. ISBN 9780444635211. PMID 25701907.
  5. ^ a b c d e f Parcell DL, Ponsford JL, Rajaratnam SM, Redman JR (February 2006). "Self-reported changes to nighttime sleep after traumatic brain injury". Archives of Physical Medicine and Rehabilitation. 87 (2): 278–85. doi:10.1016/j.apmr.2005.10.024. PMID 16442985.
  6. ^ a b c d Tham SW, Fales J, Palermo TM (June 2015). "Subjective and objective assessment of sleep in adolescents with mild traumatic brain injury". Journal of Neurotrauma. 32 (11): 847–52. doi:10.1089/neu.2014.3559. PMC 4449620. PMID 25707446.
  7. ^ a b "Sleep-wake disorders in patients with traumatic brain injury". UpToDate. Retrieved 2018-05-17.
  8. ^ a b Castriotta RJ, Wilde MC, Lai JM, Atanasov S, Masel BE, Kuna ST (June 2007). "Prevalence and consequences of sleep disorders in traumatic brain injury". Journal of Clinical Sleep Medicine. 3 (4): 349–56. doi:10.5664/jcsm.26855. PMC 1978308. PMID 17694722.
  9. ^ a b c d e f g h i j k l m n o p q r s t u v w x Wickwire EM, Williams SG, Roth T, Capaldi VF, Jaffe M, Moline M, Motamedi GK, Morgan GW, Mysliwiec V, Germain A, Pazdan RM, Ferziger R, Balkin TJ, MacDonald ME, Macek TA, Yochelson MR, Scharf SM, Lettieri CJ (April 2016). "Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group". Neurotherapeutics. 13 (2): 403–17. doi:10.1007/s13311-016-0429-3. PMC 4824019. PMID 27002812.
  10. ^ Grima N, Ponsford J, Rajaratnam SM, Mansfield D, Pase MP (March 2016). "Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis". Journal of Clinical Sleep Medicine. 12 (3): 419–28. doi:10.5664/jcsm.5598. PMC 4773614. PMID 26564384.
  11. ^ a b Castriotta RJ, Atanasov S, Wilde MC, Masel BE, Lai JM, Kuna ST (April 2009). "Treatment of sleep disorders after traumatic brain injury". Journal of Clinical Sleep Medicine. 5 (2): 137–44. doi:10.5664/jcsm.27442. PMC 2670333. PMID 19968047.
  12. ^ Franken P, Dijk DJ, Tobler I, Borbély AA (July 1991). "Sleep deprivation in rats: effects on EEG power spectra, vigilance states, and cortical temperature". The American Journal of Physiology. 261 (1 Pt 2): R198-208. doi:10.1152/ajpregu.1991.261.1.R198. PMID 1858947.
  13. ^ a b c d e f Armstrong TS, Shade MY, Breton G, Gilbert MR, Mahajan A, Scheurer ME, Vera E, Berger AM (March 2017). "Sleep-wake disturbance in patients with brain tumors". Neuro-Oncology. 19 (3): 323–335. doi:10.1093/neuonc/now119. PMC 5464298. PMID 27286798.
  14. ^ Mahmood O, Rapport LJ, Hanks RA, Fichtenberg NL (September 2004). "Neuropsychological performance and sleep disturbance following traumatic brain injury". The Journal of Head Trauma Rehabilitation. 19 (5): 378–90. doi:10.1097/00001199-200409000-00003. PMID 15597029. S2CID 1514398.
  15. ^ Shechter A, Boivin DB (2010). "Sleep, Hormones, and Circadian Rhythms throughout the Menstrual Cycle in Healthy Women and Women with Premenstrual Dysphoric Disorder". International Journal of Endocrinology. 2010: 259345. doi:10.1155/2010/259345. PMC 2817387. PMID 20145718.
  16. ^ McLaren, Declan M.; Evans, Jonathan; Baylan, Satu; Harvey, Monika; Montgomery, Megan C.; Gardani, Maria (2024-10-31). "Assessing insomnia after stroke: a diagnostic validation of the Sleep Condition Indicator in self-reported stroke survivors". BMJ Neurology Open. 6 (2): e000768. doi:10.1136/bmjno-2024-000768. ISSN 2632-6140. PMC 11529575.
  17. ^ Espie, Colin A.; Kyle, Simon D.; Hames, Peter; Gardani, Maria; Fleming, Leanne; Cape, John (2014-03-01). "The Sleep Condition Indicator: a clinical screening tool to evaluate insomnia disorder". BMJ Open. 4 (3): e004183. doi:10.1136/bmjopen-2013-004183. ISSN 2044-6055. PMC 3964344. PMID 24643168.
  18. ^ Terrio H, Brenner LA, Ivins BJ, Cho JM, Helmick K, Schwab K, Scally K, Bretthauer R, Warden D (2009). "Traumatic brain injury screening: preliminary findings in a US Army Brigade Combat Team". The Journal of Head Trauma Rehabilitation. 24 (1): 14–23. doi:10.1097/HTR.0b013e31819581d8. PMID 19158592. S2CID 22345839.
  19. ^ Farrell-Carnahan L, Franke L, Graham C, McNamee S (September 2013). "Subjective sleep disturbance in veterans receiving care in the Veterans Affairs Polytrauma System following blast-related mild traumatic brain injury". Military Medicine. 178 (9): 951–6. doi:10.7205/MILMED-D-13-00037. PMID 24005542.
  20. ^ Morries LD, Cassano P, Henderson TA (2015). "Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy". Neuropsychiatric Disease and Treatment. 11: 2159–75. doi:10.2147/NDT.S65809. PMC 4550182. PMID 26347062.
  21. ^ Hsu JC, Lee YS, Chang CN, Ling EA, Lan CT (September 2003). "Sleep deprivation prior to transient global cerebral ischemia attenuates glial reaction in the rat hippocampal formation". Brain Research. 984 (1–2): 170–81. doi:10.1016/S0006-8993(03)03128-7. PMID 12932851. S2CID 45723706.
  22. ^ Moldovan M, Constantinescu AO, Balseanu A, Oprescu N, Zagrean L, Popa-Wagner A (March 2010). "Sleep deprivation attenuates experimental stroke severity in rats". Experimental Neurology. 222 (1): 135–43. doi:10.1016/j.expneurol.2009.12.023. PMID 20045410. S2CID 24247554.
  23. ^ Lusardi TA, Lytle NK, Szybala C, Boison D (March 2012). "Caffeine prevents acute mortality after TBI in rats without increased morbidity". Experimental Neurology. 234 (1): 161–8. doi:10.1016/j.expneurol.2011.12.026. PMC 3294054. PMID 22226594.
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