ALDH1A2: Difference between revisions
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'''Retinaldehyde dehydrogenase 2''' (RALDH2) is an [[enzyme]] that in humans is encoded by the ''ALDH1A2'' [[gene]].<ref name="pmid9819382">{{cite journal | author = Ono Y, Fukuhara N, Yoshie O | title = TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3 | journal = Mol Cell Biol | volume = 18 | issue = 12 | pages = 6939–50 | year = 1998 | month = Dec | pmid = 9819382 | pmc = 109277 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8854| accessdate = }}</ref> |
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| summary_text = This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a |
| summary_text = This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of [[retinoic acid]] (RA) from [[retinaldehyde]]. Retinoic acid, the active derivative of [[vitamin A]] ([[retinol]]), is a paracrine hormone signaling molecule that functions in developing and adult tissues.<ref name="Duester">Duester, G. (2008) Retinoic acid synthesis and signaling during early organogenesis. Cell 134: 921-931. PMCID: [http://www.pubmedcentral.gov/articlerender.fcgi?tool=nihms&artid=2632951 PMC2632951]</ref> The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8854| accessdate = }}</ref> |
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Revision as of 02:39, 16 September 2010
Template:PBB Retinaldehyde dehydrogenase 2 (RALDH2) is an enzyme that in humans is encoded by the ALDH1A2 gene.[1][2]
References
- ^ Ono Y, Fukuhara N, Yoshie O (1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol Cell Biol. 18 (12): 6939–50. PMC 109277. PMID 9819382.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2".
Further reading
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