ALDH1A2

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ALDH1A2
Protein ALDH1A2 PDB 1bi9.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ALDH1A2, RALDH(II), RALDH2, RALDH2-T, aldehyde dehydrogenase 1 family member A2
External IDs MGI: 107928 HomoloGene: 68368 GeneCards: ALDH1A2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170697
NM_001206897
NM_003888
NM_170696

NM_009022

RefSeq (protein)

NP_001193826
NP_003879
NP_733797
NP_733798

NP_033048.2
NP_033048

Location (UCSC) Chr 15: 57.95 – 58.5 Mb Chr 9: 71.22 – 71.3 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Aldehyde dehydrogenase 1 family, member A2, also known as ALDH1A2 or retinaldehyde dehydrogenase 2 (RALDH2), is an enzyme that in humans is encoded by the ALDH1A2 gene.[3][4]

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a paracrine hormone signaling molecule that functions in developing and adult tissues.[5] The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels that facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.[4]

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