Mir-939 microRNA precursor family: Difference between revisions
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== See also == |
== See also == |
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* [[MicroRNA]] |
* [[MicroRNA]] |
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==References== |
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{{reflist}} |
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==Further reading== |
==Further reading== |
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[[Category:MicroRNA]] |
[[Category:MicroRNA]] |
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[[Category:MicroRNA precursor families]] |
[[Category:MicroRNA precursor families]] |
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{{genetics-stub}} |
{{genetics-stub}} |
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Revision as of 09:25, 26 March 2016
| mir-939 | |
|---|---|
| Identifiers | |
| Symbol | mir-939 |
| Rfam | RF00981 |
| miRBase family | MIPF0000490 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-939 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Human inducible Nitric Oxide Synthase
miR-939 directly regulates and translationally blocks the gene expression of human inducible nitric oxide synthase (hiNOS) by binding to its 3'UTR. There is dual regulation of hiNOS gene expression, with cytokines inducing hiNOS transcription whilst also increasing miR-939 levels.[1] Two functional binding sites within the hiNOS 3'UTR are essential for miR-939-mediated translational blockade and miR-939 has been shown to decrease cytokine-induced hiNOS expression, despite hiNOS mRNA levels and stability remaining unaffected. It has further been found that endogenous miR-939 expression in the liver may be induced by cytokines.
See also
Further reading
- ^ Guo Z, Shao L, Zheng L, Du Q, Li P, John B, et al. (2012). "miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes". Proc Natl Acad Sci U S A. 109 (15): 5826–31. doi:10.1073/pnas.1118118109. PMC 3326458. PMID 22451906.
- ^ Semaan, N.; Frenzel, L.; Alsaleh, G.; Suffert, G.; Gottenberg, J. E.; Sibilia, J.; Pfeffer, S.; Wachsmann, D. (2011). El Khoury, Joseph (ed.). "MiR-346 Controls Release of TNF-α Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization". PLoS ONE. 6 (5): e19827. doi:10.1371/journal.pone.0019827. PMC 3096642. PMID 21611196.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Nymark, P.; Guled, M.; Borze, I.; Faisal, A.; Lahti, L.; Salmenkivi, K.; Kettunen, E.; Anttila, S.; Knuutila, S. (2011). "Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer". Genes, Chromosomes and Cancer. 50 (8): 585–597. doi:10.1002/gcc.20880. PMID 21563230.
External links
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