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== Iwona Stroynowski == |
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Iwona Stroynowski (born August 8, 1950) is a Professor in the Department of Immunology and Microbiology at University of Texas Southwestern Medical Center in Dallas,TX. She discovered the process of gene expression control called attenuation in collaboration with Charles Yanofsky early in her career, an early example of a riboswitch mechanism. Later, working with Leroy Hood, she made discoveries about Major Histocompatibility Antigens, especially the non--canonical ones. |
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== Early Life and Education == |
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Iwona Fleszar<ref name=":0">{{Cite web|url=http://www.poles.org/db/s_names/Stroynowski_RA.html|title=Ryszard Stroynowski|last=|first=|date=|website=Poles.org|archive-url=|archive-date=|dead-url=|access-date=August 31, 2018}}</ref> was born on August 8, 1950<ref>{{Cite web|url=https://www.instantcheckmate.com/people/iwona-stroynowski/|title=Iwona Stroynowski|last=|first=|date=|website=Instant Checkmate|archive-url=|archive-date=|dead-url=|access-date=August 31, 2018}}</ref> in Poland. She became an American citizen in 1982.<ref>{{Cite web|url=https://profiles.nlm.nih.gov/ps/retrieve/ResourceMetadata/BBARMS|title=Letter from Iwona Stroynowski to Joshua Lederberg|last=|first=|date=May 18, 1984|website=US National Library of Medicine|archive-url=|archive-date=|dead-url=|access-date=August 31, 2018}}</ref> She received the PhD from Stanford University in 1979 in Genetics.<ref name=":1">{{Cite web|url=https://profiles.utsouthwestern.edu/profile/17070/iwona-stroynowski.html|title=Iwona Stroynowski|last=|first=|date=|website=University of Texas Southwestern|archive-url=|archive-date=|dead-url=|access-date=August 31, 2018}}</ref> Working with Charles Yanofsky, she discovered the attenuation system regulating bacterial anabolic pathways.<ref>Iwona Stroynowski, Magda van Cleemput, and Charles Yanofsky. (1982) "Superattenuation in the tryptophan operon of ''Serratia marcescens''" ''Nature'' '''298''':38-41.</ref> |
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== Academic and Research Career == |
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Iwona Stroynowski undertook an extended postdoctoral research period with Leroy Hood at California Institute of Technology, during which she changed fields from bacterial genetics to cellular immunology. Then she became an Associate Professor at University of Texas Southwestern Medical Center in the Department of Immunology and Microbiology.<ref name=":1" /> Her current rank there is Professor of Immunology and Microbiology.<ref name=":1" /> |
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Stroynowski's research has delved into the functions of the non-canonical proteins of the Major Histocompatibility Complex, particularly Qa, a protein which is produced in both membrane bound and soluble forms from the same gene, due to alternative splicing.<ref>I Stroynowski, M Soloski, MG Low, and L Hood (1987) "A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: anchoring of the product by a phospholipid tail." ''Science'' '''239:'''1302-1306. |
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</ref> Interferon induction of H-2 antigens was another of her findings.<ref>B Korber, N Mermod, L Hood, and I Stroynowski,(1988) "Regulation of gene expression by interferons: control of the H-2 promoter responses."''Science'' '''239:''' 1302-1306.</ref> Her laboratory has shown that the Qa antigen has a role in protection from tumor formation.<ref>EY Chiang and I Stroynowski (2005) "Protective immunity to disparate tumors is mediated by a nonpolymorphic class I MHC molecule." ''J. Immunol.'' '''174''': 5367-5374.</ref> |
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== Personal Life == |
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Iwona Stroynowski is married to physicist Ryszard Stroynowski of Southern Methodist University and they have two daughters.<ref name=":0" /> |
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== Honors and Awards == |
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Senior Scholar, Ellison Foundation, 2001<ref name=":1" /> |
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Revision as of 16:55, 31 August 2018
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Iwona Stroynowski
Iwona Stroynowski (born August 8, 1950) is a Professor in the Department of Immunology and Microbiology at University of Texas Southwestern Medical Center in Dallas,TX. She discovered the process of gene expression control called attenuation in collaboration with Charles Yanofsky early in her career, an early example of a riboswitch mechanism. Later, working with Leroy Hood, she made discoveries about Major Histocompatibility Antigens, especially the non--canonical ones.
Early Life and Education
Iwona Fleszar[1] was born on August 8, 1950[2] in Poland. She became an American citizen in 1982.[3] She received the PhD from Stanford University in 1979 in Genetics.[4] Working with Charles Yanofsky, she discovered the attenuation system regulating bacterial anabolic pathways.[5]
Academic and Research Career
Iwona Stroynowski undertook an extended postdoctoral research period with Leroy Hood at California Institute of Technology, during which she changed fields from bacterial genetics to cellular immunology. Then she became an Associate Professor at University of Texas Southwestern Medical Center in the Department of Immunology and Microbiology.[4] Her current rank there is Professor of Immunology and Microbiology.[4]
Stroynowski's research has delved into the functions of the non-canonical proteins of the Major Histocompatibility Complex, particularly Qa, a protein which is produced in both membrane bound and soluble forms from the same gene, due to alternative splicing.[6] Interferon induction of H-2 antigens was another of her findings.[7] Her laboratory has shown that the Qa antigen has a role in protection from tumor formation.[8]
Personal Life
Iwona Stroynowski is married to physicist Ryszard Stroynowski of Southern Methodist University and they have two daughters.[1]
Honors and Awards
Senior Scholar, Ellison Foundation, 2001[4]
- ^ a b "Ryszard Stroynowski". Poles.org. Retrieved August 31, 2018.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Iwona Stroynowski". Instant Checkmate. Retrieved August 31, 2018.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Letter from Iwona Stroynowski to Joshua Lederberg". US National Library of Medicine. May 18, 1984. Retrieved August 31, 2018.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ a b c d "Iwona Stroynowski". University of Texas Southwestern. Retrieved August 31, 2018.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ Iwona Stroynowski, Magda van Cleemput, and Charles Yanofsky. (1982) "Superattenuation in the tryptophan operon of Serratia marcescens" Nature 298:38-41.
- ^ I Stroynowski, M Soloski, MG Low, and L Hood (1987) "A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: anchoring of the product by a phospholipid tail." Science 239:1302-1306.
- ^ B Korber, N Mermod, L Hood, and I Stroynowski,(1988) "Regulation of gene expression by interferons: control of the H-2 promoter responses."Science 239: 1302-1306.
- ^ EY Chiang and I Stroynowski (2005) "Protective immunity to disparate tumors is mediated by a nonpolymorphic class I MHC molecule." J. Immunol. 174: 5367-5374.