Aquacobalamin reductase (NADPH): Difference between revisions
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#redirect [[Pyruvate dehydrogenase (NADP+)]] |
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{{enzyme |
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| Name = aquacobalamin reductase (NADPH) |
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| EC_number = 1.16.1.5 |
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| CAS_number = 110777-32-7 |
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| IUBMB_EC_number = 1/16/1/5 |
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| GO_code = 0050444 |
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| image = |
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}} |
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'''Aquacobalamin reductase (NADPH)''' ({{EC number|1.16.1.5}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
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:2 cob(II)alamin + NADP<sup>+</sup> <math>\rightleftharpoons</math> 2 aquacob(III)alamin + NADPH + H<sup>+</sup> |
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[cob(II)alamin]] and [[nicotinamide adenine dinucleotide phosphate]] ion, whereas its 3 [[product (chemistry)|products]] are [[aquacob(III)alamin]], nicotinamide adenine dinucleotide phosphate, and [[hydrogen ion]]. |
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This enzyme belongs to the family of [[oxidoreductase]]s, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The [[List of enzymes|systematic name]] of this enzyme class is '''cob(II)alamin:NADP+ oxidoreductase'''. Other names in common use include '''aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate)''', '''reductase''', '''NADPH-linked aquacobalamin reductase''', and '''NADPH2:aquacob(III)alamin oxidoreductase'''. This enzyme participates in [[porphyrin and chlorophyll metabolism]]. It employs one [[cofactor (biochemistry)|cofactor]], [[flavin adenine dinucleotide|FAD]]. |
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==References== |
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{{reflist|1}} |
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* {{cite journal |vauthors=Watanabe F, Oki Y, Nakano Y, Kitaoka S | date = 1987 | title = Purification and characterization of aquacobalamin reductase (NADPH) from Euglena gracilis | journal = J. Biol. Chem. | volume = 262 | pages = 11514–8 | pmid = 3114247 | issue = 24 }} |
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* {{cite journal |vauthors=Watanabe F, Yamaji R, Isegawa Y, Yamamoto T, Tamura Y, Nakano Y | date = 1993 | title = Characterization of aquacobalamin reductase (NADPH) from Euglena gracilis | journal = Arch. Biochem. Biophys. | volume = 305 | pages = 421–7 | pmid = 8373179 | doi = 10.1006/abbi.1993.1441 | issue = 2 }} |
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{{Other oxidoreductases}} |
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{{Enzymes}} |
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{{Portal bar|Biology|border=no}} |
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[[Category:EC 1.16.1]] |
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[[Category:NADPH-dependent enzymes]] |
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[[Category:Flavin enzymes]] |
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[[Category:Enzymes of unknown structure]] |
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Latest revision as of 15:19, 14 May 2021
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