Aquacobalamin reductase: Difference between revisions
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#redirect [[Pyruvate dehydrogenase (NADP+)]] |
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{{enzyme |
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| Name = aquacobalamin reductase |
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| EC_number = 1.16.1.3 |
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| CAS_number = 37256-39-6 |
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| IUBMB_EC_number = 1/16/1/3 |
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| GO_code = 0047138 |
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| image = |
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}} |
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'''Aquacobalamin reductase''' ({{EC number|1.16.1.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
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:2 cob(II)alamin + NAD<sup>+</sup> <math>\rightleftharpoons</math> 2 aquacob(III)alamin + NADH + H<sup>+</sup> |
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[cob(II)alamin]] and [[nicotinamide adenine dinucleotide]] ion, whereas its 3 [[product (chemistry)|products]] are [[aquacob(III)alamin]], nicotinamide adenine dinucleotide, and [[hydrogen ion]]. |
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This enzyme belongs to the family of [[oxidoreductase]]s, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The [[List of enzymes|systematic name]] of this enzyme class is '''cob(II)alamin:NAD+ oxidoreductase'''. Other names in common use include '''aquocobalamin reductase''', '''vitamin B12a reductase''', '''NADH-linked aquacobalamin reductase''', '''B12a reductase''', and '''NADH2:cob(III)alamin oxidoreductase'''. This enzyme participates in [[porphyrin and chlorophyll metabolism]]. It employs one [[cofactor (biochemistry)|cofactor]], [[flavin adenine dinucleotide|FAD]]. |
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==References== |
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{{reflist|1}} |
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* {{cite journal |vauthors=Walker GA, Murphy S, Huennekens FM | date = 1969 | title = Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems | journal = Arch. Biochem. Biophys. | volume = 134 | pages = 95–102 | pmid = 4390543 | doi = 10.1016/0003-9861(69)90255-0 | issue = 1 }} |
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{{Other oxidoreductases}} |
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{{Enzymes}} |
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{{Portal bar|Biology|border=no}} |
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[[Category:EC 1.16.1]] |
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[[Category:NADH-dependent enzymes]] |
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[[Category:Flavin enzymes]] |
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[[Category:Enzymes of unknown structure]] |
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Latest revision as of 15:43, 14 May 2021
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