Inosine pranobex: Difference between revisions
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'''Inosine pranobex''' ([[British Approved Name|BAN]]; also known as '''inosine acedoben dimepranol''' ([[International nonproprietary name|INN]]) or '''methisoprinol''') is an [[antiviral drug]] that is a combination of [[inosine]] and dimepranol acedoben (a [[salt (chemistry)|salt]] of [[acetamidobenzoic acid]] and [[dimethylaminoisopropanol]]) in a ratio of 1 to 3. Inosine pranobex has no effect on viral particles itself. Instead, it acts as an [[immunostimulant]], an analog of [[thymus|thymus hormones]].<ref>{{cite web|last=American Cancer Society |title=Inosine Pranobex |url=http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/inosine-pranobex |archive-url=https://web.archive.org/web/20100823035720/http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/PharmacologicalandBiologicalTreatment/inosine-pranobex |url-status=dead |archive-date=23 August 2010 |access-date=31 July 2013 }}</ref> It is most commonly used to treat the rare measles complication [[subacute sclerosing panencephalitis]] in conjunction with [[intrathecal]] [[interferon]] {{which|date=May 2019}} therapy.<ref>{{cite journal |title= Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy |vauthors=Campoli-Richards DM, Sorkin EM, Heel RC |journal = Drugs |date=Nov 1986 |volume = 32 |issue = 5 |pages = 383–424 |doi=10.2165/00003495-198632050-00001|pmid=2431857 |s2cid=46975349 }}</ref> |
'''Inosine pranobex''' ([[British Approved Name|BAN]]; also known as '''inosine acedoben dimepranol''' ([[International nonproprietary name|INN]]) or '''methisoprinol''') is an [[antiviral drug]] that is a combination of [[inosine]] and dimepranol acedoben (a [[salt (chemistry)|salt]] of [[acetamidobenzoic acid]] and [[dimethylaminoisopropanol]]) in a ratio of 1 to 3. Inosine pranobex has no effect on viral particles itself.{{Citation needed}} Instead, it acts as an [[immunostimulant]], an analog of [[thymus|thymus hormones]].<ref>{{cite web|last=American Cancer Society |title=Inosine Pranobex |url=http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/inosine-pranobex |archive-url=https://web.archive.org/web/20100823035720/http://www.cancer.org/Treatment/TreatmentsandSideEffects/ComplementaryandAlternativeMedicine/PharmacologicalandBiologicalTreatment/inosine-pranobex |url-status=dead |archive-date=23 August 2010 |access-date=31 July 2013 }}</ref> It is most commonly used to treat the rare measles complication [[subacute sclerosing panencephalitis]] in conjunction with [[intrathecal]] [[interferon]] {{which|date=May 2019}} therapy.<ref>{{cite journal |title= Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy |vauthors=Campoli-Richards DM, Sorkin EM, Heel RC |journal = Drugs |date=Nov 1986 |volume = 32 |issue = 5 |pages = 383–424 |doi=10.2165/00003495-198632050-00001|pmid=2431857 |s2cid=46975349 }}</ref> |
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In the UK, inosine pranobex is also indicated for mucocutaneous infections due to [[herpes simplex virus]] (type 1 and type 2) and for treatment of [[genital warts]] as adjunctive therapy to [[podophyllotoxin]] or [[carbon dioxide laser]].<ref>{{cite web | url = https://www.medicines.org.uk/emc/medicine/27089 | title = Imunovir 500mg Tablets | publisher = UK Electronic Medicines Compendium}}</ref> |
In the UK, inosine pranobex is also indicated for mucocutaneous infections due to [[herpes simplex virus]] (type 1 and type 2) and for treatment of [[genital warts]] as adjunctive therapy to [[podophyllotoxin]] or [[carbon dioxide laser]].<ref>{{cite web | url = https://www.medicines.org.uk/emc/medicine/27089 | title = Imunovir 500mg Tablets | publisher = UK Electronic Medicines Compendium}}</ref> |
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Revision as of 15:21, 18 July 2021
 Chemical structures of the three components of inosine pranobex (from top to bottom: inosine, acedoben and dimethylamino isopropanol) | |
| Combination of | |
|---|---|
| Inosine | Immunostimulant |
| Dimethylaminoisopropanol | Immunostimulant |
| Acedoben | Immunostimulant |
| Clinical data | |
| Trade names | Imunovir, Delimmun, Isoprinosine |
| Other names | Methisoprinol |
| AHFS/Drugs.com | https://www.drugs.com/international/isoprinosine-500mg.html |
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| PubChem CID | |
| ChemSpider | |
| KEGG | |
| ECHA InfoCard | 100.048.313 |
Inosine pranobex (BAN; also known as inosine acedoben dimepranol (INN) or methisoprinol) is an antiviral drug that is a combination of inosine and dimepranol acedoben (a salt of acetamidobenzoic acid and dimethylaminoisopropanol) in a ratio of 1 to 3. Inosine pranobex has no effect on viral particles itself.[citation needed] Instead, it acts as an immunostimulant, an analog of thymus hormones.[1] It is most commonly used to treat the rare measles complication subacute sclerosing panencephalitis in conjunction with intrathecal interferon [which?] therapy.[2]
In the UK, inosine pranobex is also indicated for mucocutaneous infections due to herpes simplex virus (type 1 and type 2) and for treatment of genital warts as adjunctive therapy to podophyllotoxin or carbon dioxide laser.[3]
References
- ^ American Cancer Society. "Inosine Pranobex". Archived from the original on 23 August 2010. Retrieved 31 July 2013.
- ^ Campoli-Richards DM, Sorkin EM, Heel RC (Nov 1986). "Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy". Drugs. 32 (5): 383–424. doi:10.2165/00003495-198632050-00001. PMID 2431857. S2CID 46975349.
- ^ "Imunovir 500mg Tablets". UK Electronic Medicines Compendium.
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