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'''Hovlinc''' Hovlinc comes from "hominin vlincRNA-located"<ref>{{Cite journal|last=Chen|first=Yue|last2=Qi|first2=Fei|last3=Gao|first3=Fan|last4=Cao|first4=Huifen|last5=Xu|first5=Dongyang|last6=Salehi-Ashtiani|first6=Kourosh|last7=Kapranov|first7=Philipp|date=2021|title=Hovlinc is a recently evolved class of ribozyme found in human lncRNA|url=https://pubmed.ncbi.nlm.nih.gov/33753927|journal=Nature Chemical Biology|volume=17|issue=5|pages=601–607|doi=10.1038/s41589-021-00763-0|issn=1552-4469|pmid=33753927}}</ref>. It is a self-cleaving [[ribozyme]] found in a very [[Long non-coding RNA|long noncoding RNA]] (vlincRNA) in hominins like humans, chimpanzees, and gorillas.
The '''hovlinc''' ribozyme is a self-cleaving [[ribozyme]] found in a very [[Long non-coding RNA|long noncoding RNA]] (vlincRNA) in [[Hominini|hominins]] like humans, [[Chimpanzee|chimpanzees]], and [[Gorilla|gorillas]]<ref name=":0">{{Cite journal|last=Chen|first=Yue|last2=Qi|first2=Fei|last3=Gao|first3=Fan|last4=Cao|first4=Huifen|last5=Xu|first5=Dongyang|last6=Salehi-Ashtiani|first6=Kourosh|last7=Kapranov|first7=Philipp|date=2021|title=Hovlinc is a recently evolved class of ribozyme found in human lncRNA|url=https://pubmed.ncbi.nlm.nih.gov/33753927|journal=Nature Chemical Biology|volume=17|issue=5|pages=601–607|doi=10.1038/s41589-021-00763-0|issn=1552-4469|pmid=33753927}}</ref>. Hovlinc stands for "hominin vlincRNA-located" ribozyme based on its host gene and taxonomic range. [[Ribozyme|Self-cleavage]] activity of hovlinc has been proven in humans, chimpanzees and bonobos (genus Pan), but absent in gorillas<ref name=":0" />. The discovery of this ribozyme is significant because only a small number of self-cleaving ribozymes has been reported in humans including [[Mammalian CPEB3 ribozyme]], [[Hammerhead ribozyme]] (HH9 and HH10) and a B2 [[Short interspersed nuclear element|SINE]] ribozyme<ref>{{Cite journal|last=Hernandez|first=Alfredo J.|last2=Zovoilis|first2=Athanasios|last3=Cifuentes-Rojas|first3=Catherine|last4=Han|first4=Lu|last5=Bujisic|first5=Bojan|last6=Lee|first6=Jeannie T.|date=2020-01-07|title=B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2|url=https://www.pnas.org/content/117/1/415|journal=Proceedings of the National Academy of Sciences|volume=117|issue=1|pages=415–425|doi=10.1073/pnas.1917190117|pmc=6955291|pmid=31871160}}</ref>.
Few self-cleaving ribozymes have been reported in humans including [[Mammalian CPEB3 ribozyme]], [[Hammerhead ribozyme]] (HH9 and HH10) and one B2 SINE ribozyme<ref>{{Cite journal|last=Hernandez|first=Alfredo J.|last2=Zovoilis|first2=Athanasios|last3=Cifuentes-Rojas|first3=Catherine|last4=Han|first4=Lu|last5=Bujisic|first5=Bojan|last6=Lee|first6=Jeannie T.|date=2020-01-07|title=B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2|url=https://www.pnas.org/content/117/1/415|journal=Proceedings of the National Academy of Sciences|volume=117|issue=1|pages=415–425|doi=10.1073/pnas.1917190117|pmc=6955291|pmid=31871160}}</ref>.


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== References ==<!--- See http://en.wikipedia.org/wiki/Wikipedia:Footnotes on how to create references using<ref></ref> tags, these references will then appear here automatically -->
Self-cleavage activity of Hovlinc has been proved in humans (genus [[Homo]]), chimpanzees and bonobos (genus Pan), but absent in gorillas (genus [[Gorilla]]).

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References<!--- See http://en.wikipedia.org/wiki/Wikipedia:Footnotes on how to create references using<ref></ref> tags, these references will then appear here automatically -->
{{Reflist}}
{{Reflist}}


== External links ==
== External links ==
* [https://preview.rfam.org/family/RF04188 Page for hovlinc ribozyme] at [[Rfam]]
* [http://www.example.com www.example.com]

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Revision as of 15:32, 22 July 2021

Hovlinc
Consensus secondary structure and sequence conservation of Hovlinc ribozyme (hominin vlincRNA-located)
Identifiers
SymbolHovlinc
RfamRF04188
Other data
RNA typeGene; Ribozyme
Domain(s)Hominidae
GOGO:0003824
SOSO:0000374
PDB structuresPDBe

The hovlinc ribozyme is a self-cleaving ribozyme found in a very long noncoding RNA (vlincRNA) in hominins like humans, chimpanzees, and gorillas[1]. Hovlinc stands for "hominin vlincRNA-located" ribozyme based on its host gene and taxonomic range. Self-cleavage activity of hovlinc has been proven in humans, chimpanzees and bonobos (genus Pan), but absent in gorillas[1]. The discovery of this ribozyme is significant because only a small number of self-cleaving ribozymes has been reported in humans including Mammalian CPEB3 ribozyme, Hammerhead ribozyme (HH9 and HH10) and a B2 SINE ribozyme[2].

References

  1. ^ a b Chen, Yue; Qi, Fei; Gao, Fan; Cao, Huifen; Xu, Dongyang; Salehi-Ashtiani, Kourosh; Kapranov, Philipp (2021). "Hovlinc is a recently evolved class of ribozyme found in human lncRNA". Nature Chemical Biology. 17 (5): 601–607. doi:10.1038/s41589-021-00763-0. ISSN 1552-4469. PMID 33753927.
  2. ^ Hernandez, Alfredo J.; Zovoilis, Athanasios; Cifuentes-Rojas, Catherine; Han, Lu; Bujisic, Bojan; Lee, Jeannie T. (2020-01-07). "B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2". Proceedings of the National Academy of Sciences. 117 (1): 415–425. doi:10.1073/pnas.1917190117. PMC 6955291. PMID 31871160.
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