Lloyd Demetrius: Difference between revisions
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|fields = [[Mathematician]] and [[theoretical biologist]] |
|fields = [[Mathematician]] and [[theoretical biologist]] |
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|workplaces = [[Harvard University]] |
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|alma_mater = [[University of Cambridge]]<br />[[University of Chicago]] |
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|known_for = [[Evolutionary entropy]]<br />[[Longevity|Models of longevity]] |
|known_for = [[Evolutionary entropy]] and [[Directionality Theory]]<br />[[Longevity|Models of longevity]] |
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'''Lloyd A. Demetrius''' is an American mathematician and theoretical biologist at |
'''Lloyd A. Demetrius''' is an American mathematician and theoretical biologist at the Department of Organismic and Evolutionary biology, Harvard University.<ref>{{Cite web|url=https://hwpi.harvard.edu/lloyddemetrius/home|title=Lloyd Demetrius|website=Hwpi.harvard.edu}}</ref> He is best known for the discovery of the concept, [[evolutionary entropy]],<ref>{{Cite web|url=https://www.sciencedirect.com/journal/physics-reports/vol/530/issue/1|title=Physics Reports | Boltzmann, Darwin and Directionality Theory | ScienceDirect.com by Elsevier|website=Sciencedirect.com}}</ref> a statistical parameter that characterizes Darwinian fitness in models of evolutionary processes at various levels of biological organization – molecular, organismic and social. Evolutionary entropy, a generalization of the Gibbs-Boltzmann entropy in statistical thermodynamics, is the cornerstone of directionality theory, an analytical study of evolution by variation and selection.<ref>{{Cite journal|doi = 10.3390/e16105428|doi-access = free|title = Directionality Theory and the Entropic Principle of Natural Selection|year = 2014|last1 = Demetrius|first1 = Lloyd|last2 = Gundlach|first2 = Volker|journal = Entropy|volume = 16|issue = 10|pages = 5428–5522|bibcode = 2014Entrp..16.5428D}}</ref><ref>{{Cite journal |doi = 10.1002/bies.20317|pmid = 16237668|title = Darwinian fitness, evolutionary entropy and directionality theory|journal = BioEssays|volume = 27|issue = 11|pages = 1097–1101|year = 2005|last1 = Dietz|first1 = Klaus}}</ref> The theory has applications to: a) the development of aging and the evolution of longevity;<ref>{{cite web|url=http://biomedgerontology.oxfordjournals.org/content/59/9/B902.full.pdfZformat=PDF|title=Caloric Restriction, Metabolic Rate, and Entropy|author=Lloyd Demetrius|website=Biomedgerontology.oxfordjournals.org|access-date=October 27, 2021}}</ref><ref>{{Cite web|url=https://www.harvardmagazine.com/2004/11/a-new-theory-on-longevit.html|title=A New Theory on Longevity|first=Jonathan|last=Shaw|date=November 1, 2004|website=Harvard Magazine}}</ref> b) the origin and progression of age related diseases such as cancer, and neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease;<ref>{{Cite news | url=https://www.faz.net/aktuell/wissen/medizin/streitgespraech-alzheimer-heilung-wie-nah-ist-man-wirklich-dran-13722068.html |title = Das Streitgespräch: Alzheimer: Heilung – wie nah ist man wirklich dran?|newspaper = Faz.net|last1 = Müller-Jung|first1 = Joachim}}</ref><ref>{{Cite web | url=http://news.harvard.edu/gazette/story/2015/02/a-new-understanding-of-alzheimers |title = A new understanding of Alzheimer's|website=News.harvard.edu |date = February 25, 2015}}</ref> c) the evolution of cooperation and the spread of inequality. |
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==Education== |
==Education== |
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Demetrius was a faculty member in a number of mathematics departments in the US from 1970–1979: the University of California, Berkeley; Brown University; Rutgers University; and a research scientist at the Max Planck Institute for Biophysical Chemistry, Göttingen (1980–1989). Since 1990, he has been with the Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, first as a visiting professor (1990–1992), and then as an associate in population genetics. He has held visiting professorships at MIT, University of Paris, and was an occupant of a Chaire Municipale, a distinguished visiting professorship at the University of Grenoble. His research includes the application of [[ergodic theory]] and the theory of dynamical systems to the study of evolutionary processes in biological and socio-economic systems. He has also pioneered the application of the methodology of [[quantum mechanics]] to the study of allometric relations between metabolic rate and generation time in cells. This work is the mathematical basis for the analysis of cancer and [[Inverse Warburg Effect|neurodegenerative disorders]] as metabolic and bioenergetic diseases. |
Demetrius was a faculty member in a number of mathematics departments in the US from 1970–1979: the University of California, Berkeley; Brown University; Rutgers University; and a research scientist at the Max Planck Institute for Biophysical Chemistry, Göttingen (1980–1989). Since 1990, he has been with the Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, first as a visiting professor (1990–1992), and then as an associate in population genetics. He has held visiting professorships at MIT, University of Paris, and was an occupant of a Chaire Municipale, a distinguished visiting professorship at the University of Grenoble. His research includes the application of [[ergodic theory]] and the theory of dynamical systems to the study of evolutionary processes in biological and socio-economic systems. He has also pioneered the application of the methodology of [[quantum mechanics]] to the study of allometric relations between metabolic rate and generation time in cells. This work is the mathematical basis for the analysis of cancer and [[Inverse Warburg Effect|neurodegenerative disorders]] as metabolic and bioenergetic diseases. |
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===Honors and awards=== |
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Demetrius was a recipient of a Guggenheim Fellowship in 2019.<ref>{{Cite web | url=https://www.gf.org/fellows/all-fellows/lloyd-demetrius/ | title=Lloyd Demetrius | website=John Simon Guggenheim Memorial Foundation | access-date=January 16, 2022 }}</ref> |
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==See also== |
==See also== |
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Revision as of 19:37, 22 May 2022
 | This article needs additional citations for verification. (December 2020) |
Lloyd Demetrius | |
|---|---|
 Lloyd Demetrius in 2015 | |
| Alma mater | University of Cambridge University of Chicago |
| Known for | Evolutionary entropy and Directionality Theory Models of longevity |
| Scientific career | |
| Fields | Mathematician and theoretical biologist |
| Institutions | Harvard University |
Lloyd A. Demetrius is an American mathematician and theoretical biologist at the Department of Organismic and Evolutionary biology, Harvard University.[1] He is best known for the discovery of the concept, evolutionary entropy,[2] a statistical parameter that characterizes Darwinian fitness in models of evolutionary processes at various levels of biological organization – molecular, organismic and social. Evolutionary entropy, a generalization of the Gibbs-Boltzmann entropy in statistical thermodynamics, is the cornerstone of directionality theory, an analytical study of evolution by variation and selection.[3][4] The theory has applications to: a) the development of aging and the evolution of longevity;[5][6] b) the origin and progression of age related diseases such as cancer, and neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease;[7][8] c) the evolution of cooperation and the spread of inequality.
Education
Born in Jamaica, he carried out his undergraduate studies in mathematics at the University of Cambridge, UK. He received his PhD in mathematical biology from the University of Chicago in 1967. He was then a postdoc at the University of California, Berkeley.
Career
Demetrius was a faculty member in a number of mathematics departments in the US from 1970–1979: the University of California, Berkeley; Brown University; Rutgers University; and a research scientist at the Max Planck Institute for Biophysical Chemistry, Göttingen (1980–1989). Since 1990, he has been with the Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, first as a visiting professor (1990–1992), and then as an associate in population genetics. He has held visiting professorships at MIT, University of Paris, and was an occupant of a Chaire Municipale, a distinguished visiting professorship at the University of Grenoble. His research includes the application of ergodic theory and the theory of dynamical systems to the study of evolutionary processes in biological and socio-economic systems. He has also pioneered the application of the methodology of quantum mechanics to the study of allometric relations between metabolic rate and generation time in cells. This work is the mathematical basis for the analysis of cancer and neurodegenerative disorders as metabolic and bioenergetic diseases.
See also
References
- ^ "Lloyd Demetrius". Hwpi.harvard.edu.
- ^ "Physics Reports | Boltzmann, Darwin and Directionality Theory | ScienceDirect.com by Elsevier". Sciencedirect.com.
- ^ Demetrius, Lloyd; Gundlach, Volker (2014). "Directionality Theory and the Entropic Principle of Natural Selection". Entropy. 16 (10): 5428–5522. Bibcode:2014Entrp..16.5428D. doi:10.3390/e16105428.
- ^ Dietz, Klaus (2005). "Darwinian fitness, evolutionary entropy and directionality theory". BioEssays. 27 (11): 1097–1101. doi:10.1002/bies.20317. PMID 16237668.
- ^ Lloyd Demetrius. "Caloric Restriction, Metabolic Rate, and Entropy". Biomedgerontology.oxfordjournals.org. Retrieved October 27, 2021.
- ^ Shaw, Jonathan (November 1, 2004). "A New Theory on Longevity". Harvard Magazine.
- ^ Müller-Jung, Joachim. "Das Streitgespräch: Alzheimer: Heilung – wie nah ist man wirklich dran?". Faz.net.
- ^ "A new understanding of Alzheimer's". News.harvard.edu. February 25, 2015.
External links
- Demetrius' homepage Lloyd Demetrius
- Demetrius on longevity