Adamkiewicz reaction: Difference between revisions
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The '''Adamkiewicz reaction''' is part of a biochemical test used to detect the presence of the [[amino acid]] [[tryptophan]] in proteins. When concentrated [[sulfuric acid]] is combined with a solution of protein and [[glyoxylic acid]], a red/purple colour is produced. It was named after its discoverer, [[Albert Wojciech Adamkiewicz]].<ref name="Fearon">{{cite journal|last=Fearon|first=Robert William|date=October 1920|title=A Study of some Biochemical Tests. No. 2: The Adamkiewicz Protein Reaction. The Mechanism of the Hopkins-Cole Test for Tryptophan. A New Colour Test for Glyoxylic Acid|journal=Biochem. J.|pmid=16742909|volume=14|issue=5|pages=548–564|pmc=1258917|doi=10.1042/bj0140548}}</ref><ref name="Manjila">{{cite journal|doi=10.3171/FOC.2009.26.1.E2|last=Manjila|first=Sunil|date=January 2009|title=Albert Wojciech Adamkiewicz (1850–1921): unsung hero behind the eponymic artery|pages=E2|journal=Neurosurg Focus|volume=26|issue=1| pmid = 19119888 |display-authors=etal|doi-access=free}}</ref> Pure sulphuric acid and a minimal amount of pure formaldehyde, along with an oxidizing agent introduced into the sulphuric acid, allow the reaction to proceed. |
The '''Adamkiewicz reaction''' is part of a biochemical test used to detect the presence of the [[amino acid]] [[tryptophan]] in proteins. When concentrated [[sulfuric acid]] is combined with a solution of protein and [[glyoxylic acid]], a red/purple colour is produced. It was named after its discoverer, [[Albert Wojciech Adamkiewicz]].<ref name="Fearon">{{cite journal|last=Fearon|first=Robert William|date=October 1920|title=A Study of some Biochemical Tests. No. 2: The Adamkiewicz Protein Reaction. The Mechanism of the Hopkins-Cole Test for Tryptophan. A New Colour Test for Glyoxylic Acid|journal=Biochem. J.|pmid=16742909|volume=14|issue=5|pages=548–564|pmc=1258917|doi=10.1042/bj0140548}}</ref><ref name="Manjila">{{cite journal|doi=10.3171/FOC.2009.26.1.E2|last=Manjila|first=Sunil|date=January 2009|title=Albert Wojciech Adamkiewicz (1850–1921): unsung hero behind the eponymic artery|pages=E2|journal=Neurosurg Focus|volume=26|issue=1| pmid = 19119888 |display-authors=etal|doi-access=free}}</ref> Pure sulphuric acid and a minimal amount of pure formaldehyde, along with an oxidizing agent introduced into the sulphuric acid, allow the reaction to proceed. <ref>{{Cite web|url=http://www.jbc.org/content/2/4/289.full.pdf|website=www.jbc.org|title=The Glyoxylic Acid Reaction for Tryptophan, Indol, and Skatol|access-date=2018-12-11}}</ref> |
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== References == |
== References == |
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Revision as of 10:55, 14 September 2022
The Adamkiewicz reaction is part of a biochemical test used to detect the presence of the amino acid tryptophan in proteins. When concentrated sulfuric acid is combined with a solution of protein and glyoxylic acid, a red/purple colour is produced. It was named after its discoverer, Albert Wojciech Adamkiewicz.[1][2] Pure sulphuric acid and a minimal amount of pure formaldehyde, along with an oxidizing agent introduced into the sulphuric acid, allow the reaction to proceed. [3]
References
- ^ Fearon, Robert William (October 1920). "A Study of some Biochemical Tests. No. 2: The Adamkiewicz Protein Reaction. The Mechanism of the Hopkins-Cole Test for Tryptophan. A New Colour Test for Glyoxylic Acid". Biochem. J. 14 (5): 548–564. doi:10.1042/bj0140548. PMC 1258917. PMID 16742909.
- ^ Manjila, Sunil; et al. (January 2009). "Albert Wojciech Adamkiewicz (1850–1921): unsung hero behind the eponymic artery". Neurosurg Focus. 26 (1): E2. doi:10.3171/FOC.2009.26.1.E2. PMID 19119888.
- ^ "The Glyoxylic Acid Reaction for Tryptophan, Indol, and Skatol" (PDF). www.jbc.org. Retrieved 2018-12-11.
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