Secobarbital/brallobarbital/hydroxyzine: Difference between revisions
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Hydroxyzine and secobarbital lengthen the [[Biological half-life|half-life]] of brallobarbital. Because of this long half-life, it has symptoms resembling a hangover on the next day.<ref>{{cite journal | vauthors = Yih TD, Rossum JM | title = Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication | journal = Xenobiotica; the Fate of Foreign Compounds in Biological Systems | volume = 6 | issue = 6 | pages = 355–62 | date = June 1976 | pmid = 969563 | doi = 10.3109/00498257609151647 }}</ref><ref>{{cite journal | vauthors = Fischbach R | title = Efficacy and safety of midazolam and vesparax in treatment of sleep disorders | journal = British Journal of Clinical Pharmacology | volume = 16 | pages = 167S–171S | year = 1983 | issue = Suppl 1 | pmid = 6138072 | pmc = 1428085 | doi = 10.1111/j.1365-2125.1983.tb02290.x }}</ref> |
Hydroxyzine and secobarbital lengthen the [[Biological half-life|half-life]] of brallobarbital. Because of this long half-life, it has symptoms resembling a hangover on the next day.<ref>{{cite journal | vauthors = Yih TD, Rossum JM | title = Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication | journal = Xenobiotica; the Fate of Foreign Compounds in Biological Systems | volume = 6 | issue = 6 | pages = 355–62 | date = June 1976 | pmid = 969563 | doi = 10.3109/00498257609151647 }}</ref><ref>{{cite journal | vauthors = Fischbach R | title = Efficacy and safety of midazolam and vesparax in treatment of sleep disorders | journal = British Journal of Clinical Pharmacology | volume = 16 | pages = 167S–171S | year = 1983 | issue = Suppl 1 | pmid = 6138072 | pmc = 1428085 | doi = 10.1111/j.1365-2125.1983.tb02290.x }}</ref> |
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[[Jimi Hendrix]] was under the influence of Vesparax when he died of asphyxia due to aspiration of vomit on 18 September 1970.<ref>{{Cite book | last = Brown | first = Tony | date = 1997 | title = Jimi Hendrix: The Final Days | publisher = Omnibus Press | isbn = 978-0-7119-5238-6}}</ref> |
[[Jimi Hendrix]] was under the influence of Vesparax when he died of asphyxia due to aspiration of vomit on 18 September 1970.<ref>{{Cite book | last = Brown | first = Tony | date = 1997 | title = Jimi Hendrix: The Final Days | publisher = Omnibus Press | isbn = 978-0-7119-5238-6}}</ref>{{pn|date=April 2024}} |
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== References == |
== References == |
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Revision as of 11:02, 3 April 2024
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| Combination of | |
|---|---|
| Brallobarbital | Barbiturate |
| Secobarbital | Barbiturate |
| Hydroxyzine | Antihistamine |
| Clinical data | |
| Trade names | Vesparax |
| Identifiers | |
| CAS Number | |
Secobarbital/brallobarbital/hydroxyzine was a combination tablet containing 50 mg brallobarbital, 150 mg secobarbital and 50 mg hydroxyzine[1] that was used as a sedative. It was sold under the brand name Vesparax. This drug has been withdrawn from the market in most countries.
Hydroxyzine and secobarbital lengthen the half-life of brallobarbital. Because of this long half-life, it has symptoms resembling a hangover on the next day.[2][3]
Jimi Hendrix was under the influence of Vesparax when he died of asphyxia due to aspiration of vomit on 18 September 1970.[4][page needed]
References
- ^ Lhermann J (March 1964). "[Clinical Application of a New Very Active Hypnotic Associating Sodium Secobarbital, Calcium Brallobarbital and Hydroxyzine (Uc-8130)]". Gazette Médicale de France. 71: 961–2. PMID 14142825.
- ^ Yih TD, Rossum JM (June 1976). "Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 6 (6): 355–62. doi:10.3109/00498257609151647. PMID 969563.
- ^ Fischbach R (1983). "Efficacy and safety of midazolam and vesparax in treatment of sleep disorders". British Journal of Clinical Pharmacology. 16 (Suppl 1): 167S–171S. doi:10.1111/j.1365-2125.1983.tb02290.x. PMC 1428085. PMID 6138072.
- ^ Brown T (1997). Jimi Hendrix: The Final Days. Omnibus Press. ISBN 978-0-7119-5238-6.