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* {{cite journal | vauthors = Bao J, Li D, Wang L, Wu J, Hu Y, Wang Z, Chen Y, Cao X, Jiang C, Yan W, Xu C | title = MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway | journal = The Journal of Biological Chemistry | volume = 287 | issue = 26 | pages = 21686–98 | date = June 2012 | pmid = 22570483 | pmc = 3381132 | doi = 10.1074/jbc.M111.328054 | doi-access = free }}
* {{cite journal | vauthors = Bao J, Li D, Wang L, Wu J, Hu Y, Wang Z, Chen Y, Cao X, Jiang C, Yan W, Xu C | title = MicroRNA-449 and microRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway | journal = The Journal of Biological Chemistry | volume = 287 | issue = 26 | pages = 21686–98 | date = June 2012 | pmid = 22570483 | pmc = 3381132 | doi = 10.1074/jbc.M111.328054 | doi-access = free }}
* {{cite journal | vauthors = Ma YY, Tao HQ | title = Microribonucleic acids and gastric cancer | journal = Cancer Science | volume = 103 | issue = 4 | pages = 620–5 | date = April 2012 | pmid = 22168593 | doi = 10.1111/j.1349-7006.2011.02185.x | pmc = 7713626 | doi-access = free }}
* {{cite journal | vauthors = Ma YY, Tao HQ | title = Microribonucleic acids and gastric cancer | journal = Cancer Science | volume = 103 | issue = 4 | pages = 620–5 | date = April 2012 | pmid = 22168593 | doi = 10.1111/j.1349-7006.2011.02185.x | pmc = 7713626 | doi-access = free }}
* {{cite journal | vauthors = Jungebluth P, Alici E, Baiguera S, Blomberg P, Bozóky B, Crowley C, Einarsson O, Gudbjartsson T, Le Guyader S, Henriksson G, Hermanson O, Juto JE, Leidner B, Lilja T, Liska J, Luedde T, Lundin V, Moll G, Roderburg C, Strömblad S, Sutlu T, Watz E, Seifalian A, Macchiarini P | title = Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study | journal = Lancet | volume = 378 | issue = 9808 | pages = 1997–2004 | date = December 2011 | pmid = 22119609 | doi = 10.1016/S0140-6736(11)61715-7 | doi-access = free }}{{Retracted|doi=10.1016/S0140-6736(18)31558-7|pmid=30047380|http://retractionwatch.com/?s=paolo+macchiarini ''Retraction Watch''|http://retractionwatch.com/2018/07/06/the-final-verdict-lancet-retracts-two-papers-by-macchiarini/ ''Retraction Watch''}}
* {{cite journal | vauthors = Lizé M, Klimke A, Dobbelstein M | title = MicroRNA-449 in cell fate determination | journal = Cell Cycle | volume = 10 | issue = 17 | pages = 2874–82 | date = September 2011 | pmid = 21857159 | doi = 10.4161/cc.10.17.17181 | hdl = 11858/00-001M-0000-000F-00E9-4 | url = http://pubman.mpdl.mpg.de/pubman/item/escidoc:1289654/component/escidoc:1462145/1289654.pdf | doi-access = free }}
* {{cite journal | vauthors = Lizé M, Klimke A, Dobbelstein M | title = MicroRNA-449 in cell fate determination | journal = Cell Cycle | volume = 10 | issue = 17 | pages = 2874–82 | date = September 2011 | pmid = 21857159 | doi = 10.4161/cc.10.17.17181 | hdl = 11858/00-001M-0000-000F-00E9-4 | url = http://pubman.mpdl.mpg.de/pubman/item/escidoc:1289654/component/escidoc:1462145/1289654.pdf | doi-access = free }}
* {{cite journal | vauthors = Marcet B, Chevalier B, Coraux C, Kodjabachian L, Barbry P | title = MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation | journal = Cell Cycle | volume = 10 | issue = 17 | pages = 2858–64 | date = September 2011 | pmid = 21857154 | doi = 10.4161/cc.10.17.17011 | doi-access = free }}
* {{cite journal | vauthors = Marcet B, Chevalier B, Coraux C, Kodjabachian L, Barbry P | title = MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation | journal = Cell Cycle | volume = 10 | issue = 17 | pages = 2858–64 | date = September 2011 | pmid = 21857154 | doi = 10.4161/cc.10.17.17011 | doi-access = free }}

Revision as of 02:42, 16 July 2024

miR-449
Identifiers
SymbolmiR-449
RfamRF00711
miRBase familyMIPF0000133
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology, microRNAs function to regulate the expression levels of other genes by several mechanisms. The miR-449 microRNA family encompasses three homologous small RNA molecules (miR-449a/b/c). This miR-449 cluster is located in the second intron of the CDC20B gene which both are co-transcribed.[1] This miR-449 family belongs to the miR-34/miR-449 superfamily of microRNAs that is composed of six homologous miRNAs, named miR-34a/b/c and miR-449a/b/c[1][2].They are grouped together in the same superfamily, as their seed region and their adjacent nucleotide sequences are largely conserved. The miR-449 miRNAs control the differentiation of multiciliated cells in vertebrates.[1][2]

See also

References

  1. ^ a b c Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P. (2011). ""Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway"". Nature Cell Biology. 13 (6): 693–9. doi:10.1038/ncb2241. PMID 21602795. S2CID 11514412.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ a b Ioannis Loukas, Margarita Skamnelou , Stavroula Tsaridou , Spyridoula Bournaka, Sokratis Grigoriadis, Stavros Taraviras, Zoi Lygerou and Marina Arbi (2021). "Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members". Biological Reviews. 96 (5): 2321–2332. doi:10.1111/brv.12755. PMID 34132477. S2CID 235449908.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading