N-type calcium channel: Difference between revisions
Content deleted Content added
split from Voltage-dependent calcium channel |
No edit summary |
||
| Line 18: | Line 18: | ||
|LocusSupplementaryData= |
|LocusSupplementaryData= |
||
}} |
}} |
||
[[Image:SynapseIllustration2.png|thumb|300px|Illustration of the major elements in a prototypical [[synapse]]. Synapses allow [[neuron|nerve cells]] to communicate with one another through [[axon]]s and [[dendrite]]s, converting [[action potential|electrical impulses]] into [[neurotransmitter|chemical]] signals.]] |
|||
[[Image:Synapse diag1.png|thumb|300px|Neuron A (transmitting) to neuron B (receiving)<BR>1. Mitochondrion <BR>2. Synaptic vesicle with neurotransmitters <BR>3. Autoreceptor<BR>4. Synapse with neurotransmitter released (serotonin) <BR>5. Postsynaptic receptors activated by neuro-transmitter (induction of a postsynaptic potential) <BR>6. Calcium channel<BR>7. Exocytosis of a vesicle<BR>8. Recaptured neurotransmitter]] |
|||
The '''N-type calcium channel''' is a type of [[voltage-dependent calcium channel]]. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties. |
The '''N-type calcium channel''' is a type of [[voltage-dependent calcium channel]]. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties. |
||
N-type ('N' for [[neuron]]) calcium channels are found primarily at [[chemical synapse|presynaptic]] terminals and are involved in [[neurotransmitter]] release. Strong depolarization by an action potential causes these channels to open and allow influx of Ca<sup>2+</sup>, initiating vesicle fusion and release of stored neurotransmitter. N-type channels are blocked by [[conotoxin|ω-conotoxin]]. |
N-type ('N' for [[neuron]]) calcium channels are found primarily at [[chemical synapse|presynaptic]] terminals and are involved in [[neurotransmitter]] release. Strong depolarization by an action potential causes these channels to open and allow influx of Ca<sup>2+</sup>, initiating vesicle fusion and release of stored neurotransmitter. N-type channels are blocked by [[conotoxin|ω-conotoxin]]. |
||
The [[analgesic]] drug [[ziconotide]] inhibits N-type channels. |
The [[analgesic]] drug [[ziconotide]] inhibits N-type channels. |
||
==External links== |
|||
* {{MeshName|N-Type+Calcium+Channel}} |
|||
{{Ion channels}} |
|||
[[Category:Ion channels]] |
|||
[[Category:Electrophysiology]] |
|||
[[Category:Membrane biology]] |
|||
[[Category:Integral membrane proteins]] |
|||
Revision as of 21:10, 3 June 2007
| calcium channel, voltage-dependent, N type, alpha 1B subunit | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CACNA1B | ||||||
| Alt. symbols | CACNL1A5 | ||||||
| NCBI gene | 774 | ||||||
| HGNC | 1389 | ||||||
| OMIM | 601012 | ||||||
| RefSeq | NM_000718 | ||||||
| UniProt | Q00975 | ||||||
| Other data | |||||||
| Locus | Chr. 9 q34 | ||||||
| |||||||
The N-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
N-type ('N' for neuron) calcium channels are found primarily at presynaptic terminals and are involved in neurotransmitter release. Strong depolarization by an action potential causes these channels to open and allow influx of Ca2+, initiating vesicle fusion and release of stored neurotransmitter. N-type channels are blocked by ω-conotoxin.
The analgesic drug ziconotide inhibits N-type channels.