TRIM22: Difference between revisions

TRIM22
Identifiers
Aliases	TRIM22, GPSTAF50, RNF94, STAF50, tripartite motif containing 22
External IDs	OMIM: 606559; HomoloGene: 48399; GeneCards: TRIM22; OMA:TRIM22 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	5,737,089 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; lymph node; ; Achilles tendon; ; granulocyte; ; gallbladder; ; palpebral conjunctiva; ; appendix; ; right uterine tube; ; blood;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; transcription corepressor activity; DNA-binding transcription factor activity; zinc ion binding; metal ion binding; protein binding; protein kinase binding; transferase activity;
Cellular component	cytoplasm; cytosol; Cajal body; nuclear speck; intracellular anatomical structure; nucleoplasm; nucleus; nuclear body; Golgi apparatus;
Biological process	regulation of transcription, DNA-templated; positive regulation of autophagy; interferon-gamma-mediated signaling pathway; protein trimerization; response to virus; positive regulation of DNA-binding transcription factor activity; transcription, DNA-templated; regulation of protein localization; positive regulation of NF-kappaB transcription factor activity; defense response to virus; protein ubiquitination; immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; viral process; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	10346
	n/a
	ENSG00000132274
	n/a
	Q8IYM9
	n/a
	NM_006074; NM_001199573
	n/a
	NP_001186502; NP_006065
	n/a
	Wikidata
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Revision as of 18:06, 1 March 2008

Template:PBB Controls

Tripartite motif-containing 22, also known as TRIM22, is a human gene.^[3]

Template:PBB Summary

According to researcher Stephen Barr, a molecular virologist in the Department of Medical Microbiology and Immunology, gene TRIM22 prevents the assembly of the HIV virus.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132274 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TRIM22 tripartite motif-containing 22".
^ http://www.physorg.com/news123505489.html

@@ Line 53: / Line 53: @@
 | summary_text = The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.<ref name="entrez">{{cite web | title = Entrez Gene: TRIM22 tripartite motif-containing 22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10346| accessdate = }}</ref>
 }}
+According to researcher Stephen Barr, a molecular virologist in the Department of Medical Microbiology and Immunology, gene TRIM22 prevents the assembly of the [[HIV]] virus.<ref>http://www.physorg.com/news123505489.html</ref>
 ==References==

Revision as of 18:06, 1 March 2008

References

Further reading