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added rejuvenation to focus, since has MF has initiatives like the collaboration with Organovo that imply at least a partial focus on regenerative medicine
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| area_served = Global
| area_served = Global
| product =
| product =
| focus = [[Life extension]]
| focus = [[Life extension]], [[Rejuvenation_(aging)#Modern_developments|rejuvenation]]
| method = My Bridge 4 Life, Methuselah Mouse Prize (Mprize) & [[SENS]] research funding
| method = My Bridge 4 Life, Methuselah Mouse Prize (Mprize) & [[SENS]] research funding
| revenue =
| revenue =

Revision as of 01:49, 2 June 2009

Methuselah Foundation
Founded2000
FounderAubrey de Grey & David Gobel
Type501(c)(3)
FocusLife extension, rejuvenation
Location
Area served
Global
MethodMy Bridge 4 Life, Methuselah Mouse Prize (Mprize) & SENS research funding
Key people
David Gobel, Roger Holzberg, Andrej Bartke, Craig Cooney.
Websitewww.methuselahfoundation.org

The Methuselah Foundation is a non-profit 501(c)(3) volunteer organization co-founded by Aubrey de Grey and David Gobel, which is based in Springfield, Virginia, United States.[1] A major activity of the Methuselah Foundation is the Methuselah Mouse Prize, a prize designed to hasten the research into effective life extension interventions by awarding monetary prizes to researchers who stretch the lifespan of mice to unprecedented lengths.[1] Its other activities include "My Bridge 4 Life", a community tool designed to help people deal with the diseases of aging, and funding for SENS research through the SENS Foundation research program.

Methuselah Mouse Prize

File:Mp mprize-286x59.png
The official Mprize logo

In 2003, de Grey co-founded with David Gobel the Methuselah Mouse Prize or Mprize, a prize designed to accelerate research into effective life extension interventions by awarding monetary prizes to researchers who extend the lifespan of mice to unprecedented lengths. Regarding this, de Grey stated in March 2005, "if we are to bring about real regenerative therapies that will benefit not just future generations, but those of us who are alive today, we must encourage scientists to work on the problem of aging."[2] The foundation believes that if slowing or reversing of cellular aging can be exhibited in mice, an enormous amount of funding would be made available for such research in humans, which would accelerate progress, potentially including a massive government project similar to the Human Genome Project or by private for-profit companies.[3]

The Methuselah Foundation awards prizes to researchers who extend the lifespan of a mouse to unprecedented lengths. The prize is named after Methuselah, a patriarch in the Bible said to have reached 969 years of age. Former Cambridge biogerontologist Aubrey de Grey is the chief scientist of the project, and also the co-founder alongside David Gobel. The Mprize has been covered in many news sources, including the BBC[4][5] and Fortune magazine.[6]

The prize reached $1.5 million (USD) in August 2005, $3 million in November 2005, and $4 million on December 11, 2006.[7][8][9]

Prize structure and current record holders

The foundation currently awards the following two prizes:

  • A longevity prize for extending total lifespan
  • A rejuvenation prize focusing on intervention begun at older age

The foundation collects donations in order to increase the size of the prizes. Whenever a record is broken, the researcher receives an amount based on the then current size of the prize fund and the percentage by which they exceeded the previous record.[3]

The longevity prize allows any type of intervention, including breeding and genetic engineering; only a single mouse has to be presented. As of 2005, the record holder was a mouse whose growth hormone receptor had been genetically knocked out; it lived for 1819 days (almost 5 years).[10] The Rejuvenation prize deals with peer-reviewed studies involving at least 40 animals, 20 treated and 20 control. Treatment may begin only at mid-life, and the average lifespan of the 10% longest living treated animals is used for the record. As of 2005, this record stood at 1356 days (about 3.7 years); the treatment was calorie restriction.[10]

Until November 2004, the foundation ran a Reversal prize instead of the Rejuvenation prize, with the following rules: the treatment of the mouse could be started at any age, and days before treatment had started were counted double. The winner was a mouse that did not receive any dietary or pharmacological treatment at all, just an enriched environment. The mouse lived for 1551 days (about 4.2 years).[11]

Methuselah Foundation Undergraduate Research Initiative

The Methuselah Foundation Undergraduate Research Initiative (MFURI)[12] provides undergraduate college students in any academic discipline with the knowledge and logistical support to develop projects which contribute to the advocacy or support of the Methuselah Foundation or its mission of radically extending healthy human life. The MFURI provides students within the United States education system with the opportunity to receive college credits, scholarships, and recommendations for their efforts. Students from other countries are eligible to apply for many of the available scholarships. First proposed in April 2008, the MFURI project is administered by a team of volunteer supervisors and coordinators and receives scholarship funding from the Methuselah Foundation.[13]

Staff

The staff of the Methuselah Foundation:[14]

  • David Gobel, Chief Executive Officer
  • Roger Holzberg, Chief Marketing Officer / Creative Director
  • Andrej Bartke, Co-chairman of the Scientific Advisory Board for the Mprize
  • Craig Cooney, Co-chairman of the Scientific Advisory Board for the Mprize

Donors and volunteers

On September 16, 2006, Peter Thiel, co-founder and former CEO of the online payments system PayPal, announced that he is pledging $3.5 million to the Methuselah Foundation "to support scientific research into the alleviation and eventual reversal of the debilities caused by aging." (SENS research).[15] Justin Bonomo, professional poker player, has pledged 5% of his tournament winnings for SENS research.[16] Sam Harris, a prominent nonfiction writer and scientific skeptic, is a Methuselah Mouse Prize 300 member.[17]

See also

References

  1. ^ a b "What is the Methuselah Foundation?". Methuselah Foundation. Retrieved 2009-03-14.
  2. ^ "Father of Regenerative Medicine Pushes Mprize Over the $1 Million Mark". Methuselah Foundation. March 8, 2005. Retrieved 2009-03-14.
  3. ^ a b "What is the Mprize?". Methuselah Foundation. Retrieved 2009-03-14.
  4. ^ Sprague, Valerie (September 4, 2003). "Battle for 'old mouse' prize". BBC News. Retrieved 2009-03-14.
  5. ^ de Grey, Aubrey (December 3, 2004). "'We will be able to live to 1,000'". BBC News. Retrieved 2009-03-14.
  6. ^ Stipp, David (June 14, 2004). "This Man Would Have You Live A Really, Really, Really, Really Long Time. If a mouse can survive the equivalent of 180 years, why not us? Or our kids? Scientific provocateur Aubrey de Grey has a plan". Fortune. Retrieved 2009-03-14.
  7. ^ "The $4 Million Mom". Methuselah Foundation. December 11, 2006. Retrieved 2009-03-14.
  8. ^ "Donation Details". Methuselah Foundation. Retrieved 2009-03-14.
  9. ^ "Mprize Donors". Methuselah Foundation. Retrieved 2009-03-14.
  10. ^ a b "Record Holders". Methuselah Foundation. Retrieved 2009-03-14.
  11. ^ "Reversal Prize". Methuselah Foundation. Retrieved 2009-03-14.
  12. ^ "Home Page". Methuselah Foundation Undergraduate Research Initiative (MFURI). Retrieved 2009-03-14.
  13. ^ "Our Mission". Methuselah Foundation Undergraduate Research Initiative (MFURI). Retrieved 2009-03-14.
  14. ^ "Staff". Methuselah Foundation. Retrieved 2009-03-14.
  15. ^ Davidson, Keay (September 18, 2006). "BAY AREA — Entrepreneur backs research on anti-aging — Scientist says humans could live indefinitely". San Francisco Chronicle. Retrieved 2009-03-14.
  16. ^ "Please Welcome the Newest Members of The Three Hundred". Methuselah Foundation Blog. Methuselah Foundation. January 18, 2007. Retrieved 2009-03-14.
  17. ^ "Sam Harris is a 300 member?". Methuselah Foundation forums. Methuselah Foundation. March 11, 2009. Retrieved 2009-04-09.
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