Talk:Metamizole

I have removed part of a sentence suggesting that Hoechst and Merck produce Metamizole drugs they are unable to sell in their own country for 3rd world countries. This is factually incorrect as both companies are German and are obviously producing this drug for the German market too.

I also removed a reference to Ibuprofen being a lot safer - I would request data and references on this. NSAID gastrointestinal bleeds can be a bugger too. Refdoc 04:58, 16 May 2006 (UTC)

According to eMedicine, there were 4 recorded deaths caused by Ibuprofen in United States in 1998. The article seems to imply that adverse effects are usually due to overdose.

There's a number of links to studies on safety of ibuprofen in [1]. --Itinerant1 06:43, 18 May 2006 (UTC)

Dangers very unlikely to be true

Here in Hungary "Algopyrin" (metamizol-natrium) 500mg tablet is the most popular painkiller available without prescription. Hungary is a member of the European Union, not 3rd world and the procedure to authorize new medicines is very strict here and we have good chemists domestically, including three big pharmaceutical companies, Richter, Egis and ICN. So it would not be available if it was unsafe.

This whole scare is probably a 90% untrue hoax similar to the "brain tumor scandal" about phenil-alanin sweetened chewing gums. 195.70.32.136 16:51, 2 September 2006 (UTC)

Also, to say that aspirin is safer is a lie. Ad 1 nobody knows exactly how aspirin works, even though it is 120 years old. If we have no clue about its mechanism we cannot say it is safe. Ad 2 aspirin is known to destroy the tissue of stomach and cause intestinal bleedings after years. 195.70.32.136 16:55, 2 September 2006 (UTC)

Common drug prescribed in Mexico and Latin-America.

I would like to note, that this is a _very_ common drug in Mexico, and that Doctors still prescribe it. I have never known anyonw to have a reaction to Metamizol aka. Neomelubrina. It would be good to know which drug bans have more of a economic/commercial purpose. This one sure sound like one. The article mentions a single boy having a problem in the US and they make a Federal Case out of it.

Well, I am allergic to it. --Pinnecco 16:10, 7 March 2007 (UTC)

Sweden lifted the ban on metamizole in 1995 and by 1999 they saw enough adverse reactions to the drug that they ended up banning it again. It's not just isolated cases. --Itinerant1 22:13, 6 October 2006 (UTC)

   It is known that the patients that reported problems were also taking other durgs.
   Hedenmalm K, Spigset O. Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole) Eur J Clin Pharmacol. 2002;58(4):265-274

Studies clearing the drug in the US

The following studies demonstrated no increase realtion between Metamizol and Agranulocytosis. FDA invitied Hoechst Marion Roussel to re-certify the product again but declined because of strategig/marketing issues

• No authors listed. Risks of agranulocytosis and aplastic anemia. A first report of their relation to drug use with special reference to analgesics. The International Agranulocytosis and Aplastic Anemia Study.JAMA. 1986 Oct 3;256(13):1749-57.
• Andrade SE, Martinez C, Walker AM. Comparative safety evaluation of non-narcotic analgesics. J Clin Epidemiol 1998; 51: 1357-1365
• CIOMS WORKING GROUP IV – Geneva, 1998 – Benefit-Risk Balance of Marketed Drugs: Evaluating Drug Signals —The preceding unsigned comment was added by 206.47.220.198

Spanish FAQ: http://www.zonapediatrica.com/Zonas/Fiebre/Dipirona/FAQ1.doc

(talk) 20:13, 15 March 2007 (UTC).

freely available over the counter in Spain

This article says that this drug is freely available over the counter in Spain... I am in Spain, looking at a packet right now (Nov 2006), just procured from the chemist with a prescription following a tooth extraction. It states clearly on the packet that a prescription is required. I will check with my local chemist before submitting an edit.

Peta-x 16:49, 29 November 2006 (UTC)

Yes, the previous poster is correct, I am also in Spain, (2009), I also have a packet in front of me and Metamizole is available as a prescription drug only. I also checked on-line and found the entry for the most popular Metamizole preparation in this pharmaceutical reference page:

http://www.vademecum.es/medicamento/farmacologia/n/2812/1/8/1/presentacion-y-pvp/nolotil.html

As you can see it states that Metamizole is available : "Con receta médica" meaning prescription only.

80.36.158.120 (talk) 03:44, 11 July 2009 (UTC)

IUPAC name and Molecular formula corrections

Dear wiki-editors,

I have changed the IUPAC-name for this metamizole, currently presented as sodium dipirone, by rewriting it as Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino] methanesulfonate. This is the correct name of "such metamizole = sodium dipirone".

For the same purpose, the corresponding molecular formula has been changed to the correct form, showing sodium as: (C₁₃H₁₆N₃NaO₄S)

In fact it was graphed (C₁₃H₁₇N₃O₄S), that were not the correct form, for it not presented sodium.

EgídioCampos^Say! 15:25, 6 March 2007 (UTC)

study claiming that metamizole is safe

http://www.aerzteblatt.de/v4/archiv/artikel.asp?src=heft&id=16151 92.226.133.7 (talk) 18:36, 7 December 2007 (UTC)

Yes, meta-analyzed by an employee of the manufacturer (that day Hoechst-Marion Roussel), assuming that short-term (one week or less) treatment with metamizol is not so strongly associated with GI bleedings, however, with agranulocytosis. No mention of anaphylactic/allergic reactions whatsoever (deliberate? who knows...). And mentioning the re-introduction of metamizol in Sweden in 1995 as an pseudo-argument for safety of metamizol, which was once again nullified some 6 years later, after finding out, that agranulocytosis rates were inacceptably high (in order between 1 of 10,000 - 1 of 1,000 patients medicated). Really a strong argument for metamizol.--Spiperon (talk) 13:33, 5 August 2008 (UTC)

No NSAID!

Metamizole does not belong to this group. --88.70.243.244 (talk) 18:08, 12 April 2008 (UTC)

 Are you saying it does not reduce inflammation?192.88.165.35 (talk) 18:44, 29 May 2008 (UTC)

I don't know, what IP:88.70.243.244 would've say to you, but yes, you got it -- it isn't antiinflammatory (or, it is in a minimal excent, comparable to e.g. paracetamol). It is a potent analgesic, antipyretic and less so antispasmodic/spasmolytic, but it has very little antiinflammatory effects whatsoever. It isn't really a NSAID, rather an antipyretic analgesic.--Spiperon (talk) 13:19, 5 August 2008 (UTC)

not only in the past!

Please consider that it's not all the US or UK (?). In Germany for example it's widely used - nowadays.. --88.70.253.228 (talk) 10:41, 13 April 2008 (UTC)

yes, its really strange... banned in some countries, but popular where it isnt banned. i just got it prescribed after aspirine, ibuprofen, and diclofenac didnt manage to significantly reduce the pain (i tried each one at the highest dose that the packaging allows, one after the other). i guess thats why metamizole is so popular where it isnt banned: it seems to kill pain more effectively. in the german article it says that Metamizol is the strongest painkiller that is not an acid and not an opiate. i guess when your stomach starts complaining about diclofenac and the other acidic ones, and you still want to stay away from opiates, you will want to live in a country where you can get metamizol. you just need to watch out for the symptoms of agranulocytosis, but they should be easy to spot when you are aware of the risk, and in this case the information in the german packaging advises you to immediately stop taking it and get your blood checked and see a doctor. this article should make it very clear what symptoms you need to watch out for, and what you need to do if you get those symptoms. it may be banned in the US, but many users of this wikipedia from different nations are taking it, and if everyone that would be using it would be aware of the symptoms that you need to respond to when using metamizole, there really wouldnt be a reason to ban it. but of course im biased, if i wouldnt have metamizol right now the pain and resulting sleep deprivation would probarbly have prevented me from writing this, aspirine, ibuprofen and diclofenac really failed, constant pain and only 3-4 hours of sleep per night with those, hooray for metamizol. the only drawback i noticed so far is that the reflexes dont seem to fire as fast as usual when im juggling, i drop more often than i normally would, but its still better compared to not being able to juggle at all because the pain is too strong. 79.230.3.225 (talk) 13:57, 22 June 2009 (UTC)