2,6-Dimethylpiperidine: Difference between revisions
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'''2,6-Dimethylpiperidines''' are [[chemical compound]]s with the formula C<sub>5</sub>H<sub>8</sub>(CH<sub>3</sub>)<sub>2</sub>NH. Two [[diastereomers]] exist: the achiral R,S isomer and the [[Chirality (chemistry)|chiral]] R,R/S,S pair. Dimethylpiperidines are derivatives of the [[heterocycle]] [[piperidine]], wherein two hydrogen atoms are replaced by [[methyl]] groups. |
'''2,6-Dimethylpiperidines''' are [[chemical compound]]s with the formula C<sub>5</sub>H<sub>8</sub>(CH<sub>3</sub>)<sub>2</sub>NH. Two [[diastereomers]] exist: the achiral R,S isomer and the [[Chirality (chemistry)|chiral]] R,R/S,S [[enantiomer|enantiomeric]] pair. Dimethylpiperidines are derivatives of the [[heterocycle]] [[piperidine]], wherein two hydrogen atoms are replaced by [[methyl]] groups. |
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The 2,6-dimethylpiperidines are prepared by reduction of [[2,6-dimethylpyridine]] (2,6-lutidine). The R,S isomer is favored. |
The 2,6-dimethylpiperidines are prepared by reduction of [[2,6-dimethylpyridine]] (2,6-lutidine). The R,S isomer is favored. |
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Revision as of 07:00, 12 November 2009
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| Names | |
|---|---|
| IUPAC name
2,6-Dimethylpiperidine
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| Other names
2,6-Lupetidine
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| Identifiers | |
3D model (JSmol)
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| ECHA InfoCard | 100.007.256 |
| RTECS number |
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CompTox Dashboard (EPA)
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| Properties | |
| C7H15N | |
| Molar mass | 113.20 g/mol |
| Appearance | Colorless liquid |
| Density | 0.84 g/mL |
| Boiling point | 113.2 |
| Low | |
| Solubility in other solvents | Most organic solvents |
| Basicity (pKb) | ca. 10 |
Refractive index (nD)
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1.4394 |
| Hazards | |
| Occupational safety and health (OHS/OSH): | |
Main hazards
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Flammable |
| Flash point | 53 °F |
| Related compounds | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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2,6-Dimethylpiperidines are chemical compounds with the formula C5H8(CH3)2NH. Two diastereomers exist: the achiral R,S isomer and the chiral R,R/S,S enantiomeric pair. Dimethylpiperidines are derivatives of the heterocycle piperidine, wherein two hydrogen atoms are replaced by methyl groups.
The 2,6-dimethylpiperidines are prepared by reduction of 2,6-dimethylpyridine (2,6-lutidine). The R,S isomer is favored.
The 2,6-dimethylpiperidines are of interest for their conformational properties. The R,S isomer exists largely in the chair conformation with equatorial methyl groups. The R,R/S,S isomers are attractive chiral secondary amine building blocks.[1]