Talk:Central neurogenic hyperventilation

Talk: Central neurogenic hyperventilation

Comments

After doing some research on this interesting topic I came across an article that discusses another cause of CNH in detail. The article is titled "Central neurogenic hyperventilation in an awake patient with a pontine glioma" and is authored by Siderowf AD, Balcer LJ, Kenyon LC, Nei M, Raps EC, and Galetta SL. The article describes a structural mechanism for CNH. It explains how the combination of alkaline CSF (cerebrospinal fluid) and an infiltrating pontine lesion can raise serum pH as high as 7.72. This in turn, leads to CNH. I believe this article can greatly expand your "Causes of CNH" section with another important mechanism that can induce CNH. Giantsjs2000 (talk) 01:04, 24 November 2009 (UTC)

Thanks for the information. We will expand the article accordingly. neurosoltisk (talk) 10:19, 27 November 2009 (UTC)

Hey guys, great job on the article! I don't know if you guys had trouble looking for sources for your project like we did, but one thing that helped us was requesting sources through the library. Some articles are not fully available online, but if you fill out a request form through the library, BC will actually get access to the article and they email you the pdf version. It's a great way to get additional sources that are not easily available. It takes about 1 to 2 days for them to send you the article.

chengkd (talk) 7:53, 29 November 2009 (UTC)

Hey, thanks for the advice! We were running into that problem pretty frequently. I will get in touch with the library and see if they can get access to additional articles for us.

neurosoltisk (talk) 18:53, 29 November 2009 (UTC)

The article is informative and well written. In the "Current and Future Research" section, it's stated that not much information has been collected on how to treat the illness. I found an article that may give some insight into the treatment of the disease. http://www.neurology.org/cgi/content/abstract/40/11/1715 It discusses how the administration morphine sulfate and methadone may depress ventilatory response as a result of CNH.KrystalMarquis (talk) 03:47, 29 November 2009 (UTC)

I found an article that may provide additional information on methods for treating CNH. However, I was unable to gain access to the article. I requested an interlibrary loan/ document delivery and will let you know when I receive it. The ISSN is:0340-5354. The title of the article is Treatment of central neurogenic hyperventilation with plasma exchange. Patrick Raab 06:37, 29 November 2009 (UTC) —Preceding unsigned comment added by Patrick.Raab.1 (talk • contribs)

Thanks for the additional information! Though we did briefly mention in the treatment section that morphine was used to treat CNH through depression of ventilatory response, I do agree that we can further elaborate on how/why the treatment works. Patrick, thanks for going above and beyond and requesting that article through interlibrary loan. Due to the rarity of the disorder we struggled with finding articles and did not think of using the library and its resources. Any further information on the article you found would be great. Naweston (talk) 17:58, 29 November 2009 (UTC)

Great article! It is very informative, especially with the limited resources due to the rarity of the disease, which makes understanding the disease much more difficult. The use of a graphic or diagram may be beneficial in explaining the disease. marissa.hone 29 November 2009 —Preceding undated comment added 17:10, 29 November 2009 (UTC).

Thanks for the suggestion. We struggled a bit in finding images that were available due to copyright, but we will continue to search. Naweston (talk) 17:58, 29 November 2009 (UTC)

Overall, I found your article to be very informative. I especially respect the detailed manner in which you explain the causes of CNH, taking care to address all facets of the condition while highlighting the inconclusiveness due to insufficient case study. My only suggestions concern points of clarity with respect to psychology of CNH:

In the ADDITIONAL FINDINGS section, it is stated that: “Although the majority of CNH-inducing tumors are located in close proximity to other medullary homeostatic centers, the psychological changes associated with CNH are restricted to alterations in the control of breathing.” While the inability to voluntarily control breathing is explained later in the SYMPTOMS section, the PROGNOSIS section cites altered mood, mental state, inattentiveness, an anxiety as effects of CNH. Therefore, I think it would be helpful to reword and/or reorder some of this information such that it is more cohesive and a bit less contradictory. (I’m sorry if this critique seems a bit pointed, but you did such a great job with the article in general that I figured I’d focus on something small!) Below you'll find a web address that might be useful to you; the study defines certain psychiatric effects of the CNH.

Respiratory and Psychiatric Abnormalities in Chronic Symptomatic Hyperventilation

Additionally, I thought I’d point out that there is a type-o in the ADDITIONAL FINDINGS section: “…and only 21 cases additional cases…”

Hope this helps!

Haworthk (talk) 18:08, 29 November 2009 (UTC)

Hey, thanks for the heads up! I have made the corrections as requested to make the article more coherent.

neurosoltisk (talk) 02:58, 29 November 2009 (UTC)

Hi, I researched the article that you provided and while it does discuss psychiatric abnormalities associated with chronic symptomatic hyperventilation, it does not really apply to our specific topic of central neurogenic hyperventilation, which is usually caused by tumors and has not yet been associated with psychiatric or respiratory abnormalities. It is important to make the distinction between CNH and other forms of hyperventilation, as CNH is rare due to its non-association with any emotional or psychological causes. Naweston (talk) 20:07, 29 November 2009 (UTC)