Talk:Long-term depression

References?

although some references are named by author/year, the bibliography to look up the cited publications is missing...

-- 89.247.78.201 (talk) 11:57, 30 September 2008 (UTC)

Suggestions from BI481 Classmates

Synaptic depression

There is a very useful and interesting article by P. G. Montarolo, E. R. Kandel and S. Schacher that examines the gill withdrawal reflex in Aplysia, which you may consider including in the article due to the model nature of the organism and its critical importance in discoverying the underlying mechanisms of this process. The paper explores the short term and long term synaptic depression caused by FMRFamide and compares it to dopamine and low-frequency stimulation. It also demonstrates that the mechanisms of long term depression result from gene products when the administer the FMRFamide in the presence of an inhibitor of protein synthesis, anisoymcin, resulting in the absence of the previously observed long term depression.

Hassan.zayn (talk) 03:07, 25 November 2009 (UTC)

AMPA receptors

Hey guys, good job so far. This is an interesting topic and I'm sure that there is a lot of external information on it so it may be hard to decide what you want to include or not. I think that it would be good to talk a little about the role of some important neurotransmitters like Serotonin in facilitating long-term depression by inducing internalization of AMPA receptors. There is an article that you'll find helpful in the journal of Physiology titled: Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization, by Z.Yan etc. I'll let you know if I find other information.

Kristaqkoci (talk) 05:51, 28 November 2009 (UTC)

EPSPs, calcium, Hebbian model, etc

• In the Hippocampus section, be sure to refer to EPSPs with the full name the first time they are mentioned.

• You mention that LTD in the visual cortex is homosynaptic. How do the types of LTD function in the hippocampus and the cerebellum?

• In organizing your article, you may want to talk about the role and importance of calcium before you go into the section of STDP.

• You could include a section concerning the Hebbian model of learning and how LTD is involved in this process. I found a paper by Mark Bear called Bidirectional Synaptic Plasticity: from Theory to Reality that discusses the Hebbian model and the BCM model. It goes into a detail about the visual cortex and LTD. It does mention some interesting research about visual deprivation and retinal inactivity. The web address of the paper is http://bearlab-s1.mit.edu/BearLab/PDFs/bear03.pdf.

Katie1341 (talk) 04:46, 29 November 2009 (UTC)

Comment 4

You might consider merging the "Types" heading and the "Mechanisms that weaken synapses" heading into one "Mechanisms" heading. This would be cleaner and more concise. It would also be interesting, in light of the Kauer and Malenka "Synaptic plasticity and addiction" review paper, to mention the effect of amphetamine use on LTD. The paper in the journal Science by Brebner et al, titled "Nucleus accumbens long-term depression and the expression of behavioral sensitization" might be useful in this area. Finally, since memory is such an important area of LTD, it would probably be good if that section was expanded to include more sources of information. Matthew Cedar Warman (talk) 17:55, 29 November 2009 (UTC)

Comment 5

In the mechanisms that weaken synapses, you may consider adding a visual that shows the presynaptic and postsynaptic membranes showing the respective postsynaptic receptors. A visual of the pathway may be of aid to the reader in understanding the distinction between AMPA and NMDA receptors and what each receptor does. An image of second messenger pathways may also be of help.

One section you may consider adding is one which discusses depressive disorders. Nobuo Kato (2009) discusses the mechanisms of electroconvulsive therapy on depression disorders, which may be interesting to add. Although the mechanisms for this therapy is not thoroughly understood, it might be interesting to include recent theories on how ECT impacts GABAergic dysfunction as addressed in Kato’s paper, "Neurophysiological mechanisms of electroconvulsive therapy for depression". Daigleal (talk) 23:40, 29 November 2009 (UTC)

Comment 6

Great article overall. Just a few things, you may want to make internal wiki links for NMDA receptors, mGluR receptors, and endocannabinoids in your opening in case people are unfamiliar with them. Also, the Types section could be changed, either by expanding on each subtype a little bit or by merging them into one section and just making them separate paragraphs. In the first line of the spike-timing dependent plasticity section, the link for neuroplasticity should probably be one word since that's how it is on the page it points to. It also might be interesting to include some diseases or disorders associated with LTD. Pmcb97 (talk) 00:42, 30 November 2009 (UTC)

Comment 7

I liked the page. The information you presented gelled well with what we learned in class about LTD and allowed me to gain a deeper understanding of the mechanism. I have to agree with some of the above comments that you could use a little beefing up of the 'Motor Learning and Memory' section. Here are some links that may help you add more to that section: [[1]], [[2]], [[3]]. Maybe talk about the signal-to-noise ratio and LTDs role in helping to assign importance to data. Perhaps you can reference Kim Peek as an example of someone who can remember everything but is unable to make sense/assign importance to all the data he has accumulated. Rickxicity (talk) 22:32, 29 November 2009 (UTC)

Comment 8

I think this article is very well written, probably the best I've read so far. I found the section about LTD in the visual cortex to be particularly interesting and I think you could discuss it in more depth. Also, I liked how you talked about the experiments concerning LTD and memory in rats, but I think it would benefit your page to discuss the relationship between LTD and human memory disorders. You should explore the consequences of LTD impairment in humans and the inability to forget anything previously learned. I think you should also consider LTD and its role in disorders including Alzheimer's disease, and what further research of LTD could mean for better understanding human memory disorders. These articles might be helpful:

 http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9X-4TX33K6-1&_user=521319&_coverDate=04%2F30%2F2009&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000026018&_version=1&_urlVersion=0&_userid=521319&md5=b41828096e5aece1fff15dc008f72c83

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4VYP91J-1&_user=521319&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000026018&_version=1&_urlVersion=0&_userid=521319&md5=5a9c8e2293349cf0c05ba3218412520d

Overall, I wouldn't change much about the content or setup of your article, but would consider adding a discussion relating LTD and human memory disorders including what is already known and what needs to be studied in the future. Brikathleen (talk)