MFGE8: Difference between revisions
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== Function == |
== Function == |
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Mfge8 contains a [[phosphatidylserine]] (PS) binding domain, as well as an [[Arginine]]-[[Glycine]]-[[Aspartic acid ]] motif, which enables the binding to [[integrins]]. Mfge8 binds PS, which is exposed on the surface of |
Mfge8 contains a [[phosphatidylserine]] (PS) binding domain, as well as an [[Arginine]]-[[Glycine]]-[[Aspartic acid ]] motif, which enables the binding to [[integrins]]. Mfge8 binds PS, which is exposed on the surface of [[apoptotic]] cells. Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell. |
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==References== |
==References== |
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Revision as of 18:56, 25 May 2011
Template:PBB Milk fat globule-EGF factor 8 protein Mfge8), also known as lactadherin, is a protein which in humans is encoded by the MFGE8 gene.[1][2]
Species distribution
Mfge8 is secreted protein found in vertebrates, including mammals as well as birds.
Function
Mfge8 contains a phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. Mfge8 binds PS, which is exposed on the surface of apoptotic cells. Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.
References
- ^ "Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein".
- ^ Collins C, Nehlin JO, Stubbs JD, Kowbel D, Kuo WL, Parry G (1997). "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25". Genomics. 39 (1): 117–8. doi:10.1006/geno.1996.4425. PMID 9027496.
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Further reading
 | This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it. |