Talk:Fluoxetine: Difference between revisions

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I hear about scientologists being behind the Prozac Truth website, can anyone confirm?

My guess is yes, since they cite absolutely no research papers on the subject or provide otherwise meaningful data. --Iosif 23:31, 13 October 2005 (UTC)[reply]

If Scientologists are the only people who put stuff on the Net without citing their sources, then the Wikipedia is OT III. (Joke.) Anville 13:50, 29 October 2005 (UTC)[reply]

According to Prozac.com, Prozac is the best thing since sliced bread.

According to ProzacTruth.com, Prozac is a creation of Devil.

Prozac.com is, of course, strongly biased. It's just an advertisement. But is ProzacTruth.com biased as well, only from a different angle? Is the real truth somewhere between prozac.com and prozactruth.com?

I am about to treat my depression with Fluoxetine hydrochloride and it is very important to me to have as objective knowledge as possible, before I start any treatment. -- Unknown author, Jan 2003

If it's objectivity you need, you're in the wrong place ;^) Jordan Langelier

Why? And better yet, what would you recommend as a balanced alternative? (for an opinion, obviously.) --Gutza 21:33, 18 Jul 2004 (UTC)

Just in case someone else comes along with the same questions... Studies show that the highest efficacy for clinical depression is in using both anti-depressants and cognitive therapy. The idea is that the anti-depressants help with the immediate "fog", but the cognitive therapy will help treat underlying issues or behavior that may increase or cause depressive feelings. Cognitive therapy on its own has a better one year success rate than antidepressants alone, but the best bang for the buck is supposed to be both. YMMV. I had clinical depression about twenty years ago, dislike drugs, and found CBT to be more helpful. 67.10.133.121 02:38, 12 February 2006 (UTC)[reply]

If you want balanced and objective information on Fluoxetine and the other SSRIs then look to the large body of research papers published in reputable, peer-reviewed journals. There are about 400 papers on fluoxetine and about 25 of these are meta-analyses. If you don't want to be beholden to other's possibly biased opinions then you will have to do your own secondary research. The least you will have to do is study at least a couple of the meta-analyses. You can find the abstracts on PubMed and the full articles in a large reference libarary. It is important to bear in mind that fluoxetine entered clinical use for depression in 1988 and has given to literally millions of people around the world since then. People that have obtained relief from their depression on fluoxetine and other SSRIs don't set-up websites or blogs pouring scorn and vitriol on pharmaceutical manufacturers and pschiatrists and they don't loiter on message boards whining about withdrawal or adverse reactions. Those that have benefiited from SSRIs are busy living their lives. Certainly some people do experience serious adverse responses to SSRIs and withdrawal can be harsh especially with SSRIs that have a short half-life (fluoxetine has the longest half-life of all the SSRIs) and this can be very debilitating. However, depression itself is debilitating. SSRI withdrawal typically lasts for 2-4 weeks and it can involve a relapse in depressive symptoms. The use of the SSRI -- assuming you have found one that works for you -- though will typically give you many months or even years of low-level depression or no-depression life. If your depression does have a psychological basis (not all depresssions do) then you may benefit from CBT. CBT is the only psychotherapy with any evidence of efficacy for the treatment of depression. A common occurence with people on SSRIs is to forget what they felt like prior to commencing treatment with SSRIs after a few months and to begin attributing the residual symptoms of the depression (eg. apathy, fatigue) to the SSRI. This often prompts an abrupt cessation of SSRI usage and the consequent withdrawal symptoms. If you are suffering from depression it is useful to keep a diary. Take note of how you feel before commencing with the SSRI and record how you symptoms are changing with the SSRI. With the benefit of your diary you are better able to determine if the SSRI is causing some particular symptom or if it is something due to the depression. Stay away from all the Scientology front websites and organisations. The Scientologists are only interested in taking your money and enslaving you. The CoS has the blood of Lisa McPherson on its grasping hands[1]. flavius 12:16, 19 March 2006 (UTC)[reply]

"The controversial Prozac approval process described, as well as side effects of other SSRIs and other types of medication, can be found on Prozac Truth, The Untold Story website."

I am not about to treat anything with Prozac, I was just curious about the drug, and the quotation above looks pretty POV to me, that site doesn't look so trustworthy as to invest it with such a powerful statement from Wikipedia. Other thoughts? --Gutza 22:59, 4 Dec 2003 (UTC)

Me again. I went ahead and edited, removing that paragraph altogether and replacing it with a NPOV pointer to the resources. I have no bias whatsoever regarding this drug, feel free to revert if you think that was too drastic. --Gutza 23:06, 4 Dec 2003 (UTC)

Truth is not the averaging of polarized opinions. Truth is just truth. If you value your health and your sanity, seek the truth and don't settle for less - there is a road out of mental illness. However, the solution to depression does not include side effects such as suicide and depression.

" Lawsuits amounting to millions were instigated, alleging the drug made users feel suicidal and/or caused other serious side effects." You may want to look into rewording this phrase. I could be wrong but I'm pretty sure I read that their was a link between suicide and prozac, not that it caused suicidal feelings. The latter implies that it physically made users feel suicidal which might be true, but I thought that the issue was that it numbed the emotions and social attachment in already depressed people. \

This is real late in coming, but I will never take any of those drugs again. I will take street drugs before I take any of the SSRI's. Those things are the worst thing in the world, I will jump in front of a speeding train first.

There seems to be a logical fallacy in the above post. SSRI's are street drugs, aren't they? ;)

Spamming on sexual dysfunction issues all over

Many articles have been edited pasting the same statements over and over again. Warnings were not attended. This modus operandi is vandalism. Perhaps, this article needs to be reverted and temporarily blocked. --Octavio L 06:16, 14 October 2005 (UTC)[reply]

This user is promoting his own research, but fails to cite a credible source. The source he alludes to does not support his assertions. Revert on sight. I will block if he carries on. JFW | T@lk 08:25, 14 October 2005 (UTC)[reply]

Glandular fever

Does fluoxetine cure glandular fever?

No, it doesn't. It's used in chronic EBV, though, or what we tend to call chronic fatigue syndrome. JFW | T@lk 07:35, 28 October 2005 (UTC)[reply]

Prozac weekly vs generic question

"4 or 5 regular 20mg doses taken at once will have a similar effect to Prozac Weekly with significantly lower costs, especially when using generic versions." Is it really true that the weeklong dose of prozac is no different than taking a larger dose of ordinary prozac? I'm pretty sure that withdrawal symptoms start within a day or two with ordinary prozac, so it seems like a once-a-week dosage would be inappropriate unless it has some extended release mechanism. (unsigned by 140.247.144.121)

Quoting from the drug monograph:

[Fluoxetine has an] elimination half-life of 1 to 3 days after acute administration and 4 to 6 days after chronic administration and its active metabolite, norfluoxetine [has an] elimination half-life of 4 to 16 days after acute and chronic administration [respectively] ... The long elimination half-lives of fluoxetine and norfluoxetine assure that, even when dosing is stopped, active drug substance will persist in the body for weeks. (rxlist.com monograph)

The Prozac Weekly formulation is enteric-coated primarily to avoid GI irritation from the larger dose. The coating delays absorption but does not signficantly prolong it, meaning that the total dose is absorbed after 1-2 hours rather than 20-45 minutes. Fluoxetine can be taken weekly due to its extremely long half-life, not due to any mechanical extended release formulation. In fact, I am not aware of any possible formulation that could extend oral absorption over 5-7 days. Typically material passes through the GI tract over no longer than 48-72 hours, usually closer to 24 hours. --Bk0 (Talk) 23:19, 15 December 2005 (UTC)[reply]

@@ Line 33: / Line 33: @@
 Just in case someone else comes along with the same questions... Studies show that the highest efficacy for clinical depression is in using both anti-depressants and [[cognitive therapy]]. The idea is that the anti-depressants help with the immediate "fog", but the cognitive therapy will help treat underlying issues or behavior that may increase or cause depressive feelings. Cognitive therapy on its own has a better one year success rate than antidepressants alone, but the best bang for the buck is supposed to be both. YMMV. I had clinical depression about twenty years ago, dislike drugs, and found CBT to be more helpful. [[User:67.10.133.121|67.10.133.121]] 02:38, 12 February 2006 (UTC)
+If you want balanced and objective information on Fluoxetine and the other SSRIs then look to the large body of research papers published in reputable, peer-reviewed journals.  There are about 400 papers on fluoxetine and about 25 of these are meta-analyses.  If you don't want to be beholden to other's possibly biased opinions then you will have to do your own secondary research.  The least you will have to do is study at least a couple of the meta-analyses.  You can find the abstracts on PubMed and the full articles in a large reference libarary.  It is important to bear in mind that fluoxetine entered clinical use for depression in 1988 and has given to literally millions of people around the world since then.  People that have obtained relief from their depression on fluoxetine and other SSRIs don't set-up websites or blogs pouring scorn and vitriol on pharmaceutical manufacturers and pschiatrists and they don't loiter on message boards whining about withdrawal or adverse reactions.  Those that have benefiited from SSRIs are busy living their lives.  Certainly some people do experience serious adverse responses to SSRIs and withdrawal can be harsh especially with SSRIs that have a short half-life (fluoxetine has the longest half-life of all the SSRIs) and this can be very debilitating.  However, depression itself is debilitating.  SSRI withdrawal typically lasts for 2-4 weeks and it can involve a relapse in depressive symptoms. The use of the SSRI -- assuming you have found one that works for you -- though will typically give you many months or even years of low-level depression or no-depression life.  If your depression does have a psychological basis (not all depresssions do) then you may benefit from CBT.  CBT is the ''only'' psychotherapy with any evidence of efficacy for the treatment of depression.  A common occurence with people on SSRIs is to forget what they felt like prior to commencing treatment with SSRIs after a few months and to begin attributing the residual symptoms of the depression (eg. apathy, fatigue) to the SSRI.  This often prompts an abrupt cessation of SSRI usage and the consequent withdrawal symptoms.  If you are suffering from depression it is useful to keep a diary.  Take note of how you feel before commencing with the SSRI and record how you symptoms are changing with the SSRI.  With the benefit of your diary you are better able to determine if the SSRI is causing some particular symptom or if it is something due to the depression.  Stay away from all the Scientology front websites and organisations.  The Scientologists are only interested in taking your money and enslaving you.  The CoS has the blood of Lisa McPherson on its grasping hands[http://www.lisamcpherson.org/]. [[User:Flavius vanillus|flavius]] 12:16, 19 March 2006 (UTC)
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