Tet methylcytosine dioxygenase 1: Difference between revisions
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'''Tet methylcytosine dioxygenase 1''' is a [[enzyme]] that in humans is encoded by the TET1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Tet methylcytosine dioxygenase 1 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=80312 | accessdate = 2012-07-26T20:28:02.557056-08:00 }}</ref> |
'''Tet methylcytosine dioxygenase 1''' is a [[enzyme]] that in humans is encoded by the TET1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Tet methylcytosine dioxygenase 1 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=80312 | accessdate = 2012-07-26T20:28:02.557056-08:00 }}</ref> |
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Tet1 [[catalysis|catalyzes]] the conversion of the modified [[DNA]] base [[5-methylcytosine]] (5-mC) to [[5-hydroxymethylcytosine]] (5-hmC).<ref name="PMID:19372391">{{Cite pmid|19372391}}</ref> Tet1 produces 5-hmC by [[oxidation]] of 5-mC in an [[iron]] and [[alpha-ketoglutarate]] dependent manner.<ref name="PMID:21778364">{{Cite pmid|21778364}}</ref> The conversion of 5-mC to 5-hmC has been proposed as the initial step of active [[DNA demethylation]] in mammals.<ref name="PMID:21778364">{{Cite pmid|21778364}}</ref> |
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== References == |
== References == |
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Revision as of 15:07, 27 July 2012
Template:PBB Tet methylcytosine dioxygenase 1 is a enzyme that in humans is encoded by the TET1 gene.[1]
Tet1 catalyzes the conversion of the modified DNA base 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC).[2] Tet1 produces 5-hmC by oxidation of 5-mC in an iron and alpha-ketoglutarate dependent manner.[3] The conversion of 5-mC to 5-hmC has been proposed as the initial step of active DNA demethylation in mammals.[3]
References
- ^ "Entrez Gene: Tet methylcytosine dioxygenase 1". Retrieved 2012-07-26T20:28:02.557056-08:00.
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Further Reading
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