Talk:Dopamine reuptake inhibitor

Untitled

Sounds ok.

Daevatgl 20:35, Jun 16, 2004 (UTC)

May 6 2005 edits The Biochemical Basis of Neuropharmacolgy Oxford Press 1996 Chapter 9 Dopamine--McDogm 17:21, 6 May 2005 (UTC)

Should add Adderall in here -- I would but couldnt figure out the proper medical name for it or where it fits in terms of dopamine release.

Binding ligands?

Isn't it the case that most phenethylamine DARIs inhibit by attaching as if they were the regular transporters, and others like the cocaine tropane-types attach or bind as a ligand to the transporter in an entirely different way? It is odd that such a tropane type ligand, if I'm not mistaken, attaches with a higher affinity? 71.34.103.210 (talk) 00:45, 19 April 2009 (UTC)

Two Errors corrected 9-7-09

I've corrected the following two errors:

• removed benzatropine from the list of DRIs. Benzatropine is an anticholinergic, it has nothing to do with dopamine and dopamine receptors. Its use in Parkison's and other movement disorders has to do with the balance of activity between cholinergic and dopaminergic components of the deep brain movement centers, but it has no effect on dopamine itself.
• added cocaine to the pharmaceutical agents; in the USA it is schedule II, not schedule I, and has important medical uses in ENT/OHNS surgery. —Preceding unsigned comment added by 208.80.67.18 (talk) 17:11, 6 September 2009 (UTC)

Benzatropine/benztropine is a DRI, hence why I put it on the list: Source. And while cocaine is a pharmaceutical, it's primarily a street drug and its medical use is almost unheard of, so I think the illicit category would be more appropriate. Not to mention its DRI actions aren't actually related to its clinical use either. el3ctr0nika (Talk | Contribs) 09:42, 24 January 2010 (UTC)

Dubious

I tagged the link to physical dependence as dubious. To my knowledge, straight DRIs such as methylphenidate don't cause a lot of "physical dependence". This is partly a language issue: These drugs do cause homeostatic changes in the brain, but philosophy of the mind notwithstanding, I think that that's not usually what is meant by "physical dependence". In my book, "physical dependence" means that there are serious peripheral symptoms upon discontinuation. Suboptimal Username (talk) 17:15, 10 June 2010 (UTC)

There are withdrawal symptoms upon discontinuation, look at cocaine - huge withdrawal symptoms. Even methylphenidate when used at a high enough dose will give withdrawal symptoms --Axxaer (talk) 04:17, 27 September 2010 (UTC)

Cocaine is totally different though, according to the wiki page it is a Serotonin, Norepinephrine and Dopamine reuptake inhibitor. Methylphenidate as well is not selectively a dopamine reuptake inhibitor. I don't really get why you make the link between those two and DRIs Robinsona (talk) 20:47, 11 December 2010 (UTC)

Dopamine reuptake inhibitor that acts just toward the DAT class which dopamine releasing agents can select out of one of either

e.g. dextro- & levo- methamphetamine. Could there be a drug similar to cocaine for instance, that only preforms the function of the former mentioned dextro- (alone) or levo- (alone) by only inhibiting reuptake on those sort of transporters potentially at all? Nagelfar (talk) 05:47, 8 July 2010 (UTC)

Roosevelt University PSYC 336 Project

Basic Outline

List of DRI’s and Intro: will simply be edited according to our research findings, and addition DRI’s not listed will be added, and the current list verified.

Process

This section will contain information about the biological processes induced by dopamine reuptake inhibitors. The process within the synapses will be covered, alone with any side effects, either long term or short term, as well as any effects caused by dopamine increase.

History

This section will cover the history of the discovery and use of dopamine reuptake inhibitors. The development over the last half century of the targeting of transporters as a means of concentrating levels of neurotransmitters within the synapse will be discussed, as well as a general history of the drugs and their discoverers.

Possible affects on cognition

This section will focus on the affects that DRI can have on emotion, as well as the possible side affects of DRI's. Another subject that this section will talk about is the controversy behind DRI's in drugs. This will touch on usage and abuse of DRI's. This section will also touch on the short term affects and the long term affects of DRI's.

— Preceding daniadams9121 comment added by Narmstrong484 (talk • contribs) 18:49, 9 October 2012 (UTC)

Instructor's comments

• Group, I like your outline, but I don't see how you're going to be able to write this with primary sources as you've listed. Look for secondary sources such as books or review articles. Use a medically based database such as PubMed. I will also email this group a chapter on dopamine. It's a bit old, but it might be lead to other sources.

Neuropsychprof (talk) 22:00, 10 October 2012 (UTC)

Smallman12q comments

• Needs more sourcing.
• There is a lot of research in this. Discuss current/future research.
• Add similar sections to those in Selective serotonin reuptake inhibitor.

This is a good start...but needs a lot of expansion/sourcing.Smallman12q (talk) 22:38, 27 October 2012 (UTC)

Comments

It looks like there needs to be more sources that are actually contained within the article rather than just floating at the top. More sections should also be added to go into details about subjects raised in the introduction. I would agree with smallman12 that the article needs to be expanded and more effort needs to be put into finding sources.

Pmisner2009 (talk) 16:39, 28 October 2012 (UTC)

I agree that maybe more sources would help generate a better informative article. I think what you have so far is good but maybe you could expand upon certain parts as in the dopaminergic pathway and get into more detail. R.EEGbrittry (talk) 19:51, 29 October 2012 (UTC)