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Hi I have MD.
Hi I am a retired MD.


I have interest in Epidemics of emergent diseases, medical solutions for pandemics/epidemics like malaria kala azar chagas etc.
I have interest in Epidemics of emergent diseases, medical solutions for pandemics/epidemics like malaria kala azar chagas etc.

Revision as of 03:56, 22 November 2013

This user is interested in
DNA and genetics.


Hi I am a retired MD.

I have interest in Epidemics of emergent diseases, medical solutions for pandemics/epidemics like malaria kala azar chagas etc. in DNA and DNA genealogy. in ancient history. chess. museums of history/antiques

Abraham modal haplotype

The Abraham modal haplotype is a set of DNA sequences that are inherited together) on the Y-chromsome that has been hypothesized to mark the split between the Jewish and the Arabic lineages. A modal haplotype is used in Genetic Genealogy to trace back ancestry of a group of people of common descent supported by paper trail or historical evidence. MRCA is supposed to have the Modal haplotype while all his descendents either have it or cluster around it. It is the ancestral Haplotype of J1-Cohen modal haplotype(Y-chromosomal Aaron) removed only by 2 (one step) mutations from each other. After figuring the Modal Haplotype an estimation of the time to the most recent common ancestor TMRCA of MRCA of Jews and Arabs of haplogroup J1 (subclade J1e) to 4,125±525, a time close to that of the legendary Biblical split into the Jewish and the Arabic lineages. [1] [2][3]klyosov re-syncronized clustering methods to reestablish time to Abraham again in another study to 4,300±500 ybp (years before present), and the "J1 Abraham Modal Haplotype" which he calculated based on "Cohen Modal Haplotype" (CMH). From MRCA a split occurred between the Jewish and the Arabic lineages in haplogroup J1 (J1e*) that is clear on the haplotypes maps of the study, and it is reminiscent of the story of Abraham and his siblings, Ishmael, Isaac, and Jacob, the patriarchs of the Arabs and the Jews.[4] , based on previous studies that found that J1-Cohen Modal Haplotype and Galilee modal haplotype and Israeli Bedoins Modal Haplotype diverged from Cohan Modal Haplotype (Y-chromosomal Aaron)in haplogroup J1(Eu10)[5][6] where Galilee modal haplotype was the ancestral haplotype of the Arabs dominant among all current all Arabs (Yemenites and Adnanites) found in Yemen, Palestine and North Africa. [7], later study found J1e (p58) combines both J1-Cohanim and J1-Arabs[8][9] Later a subclade of J1e called L147.1 the dominant subclade of J1 is exclusively Arab abd Cohanim J1 (where J1 Ethiopian and J1 Assyrians dont have the YCAII=22,22 and the high DYD388)[10] [11].

Rabbi Kleiman in his book DNA and Tradition states: "Since Abraham was only removed from Aaron few hundred years, then CMH is the genetic signature of Abraham father of Jacob and Ishmael, and that explain why we also find the CMH in high numbers among Arabs who traditionally claim to be the progeny of Abraham through his son Ishmael, who would also have to be carrying Abraham's male genetic signature".[12]

Galilee modal haplotype

Galilee Modal Haplotype (also known as "modal haplotype of the Galilee" or "MH Galilee") is a haplotype (DNA marker) that represents Arab ancestry.

Galilee modal haplotype was discovered in a study by Nebel et al. (2000) among Palestinian Arabs and is characterized by the high number of the STR DYS388=17 (the haplotype is DYS19-14/DYS388-17/DYS390-23/DYS391-11/DYS392-11).[13]

Galilee modal haplotype is closely linked to the Haplogroup J1-Cohen Modal Haplotype but is only found in Arabs[14][15].

The presence of Galilee modal haplotype (absent from Jews and Muslim Kurds) at a significant frequency in three separate geographic locales Galilee Palestinians, Yemen (Thomas et al. 2000), and North African Arabs (Bosch et al. 2001), is considered evidence for the Arabic expansion of 7th century and of Arab ancestry[16].

Galilee modal haplotype is notable for its high number in STR: DYS388, found only in populations originating in the Middle East, is a useful tool as a region-specific DNA marker[17].

The rarity of haplogroup J1-monophyletic clade: J-M267-YCAIIa22-YCAIIb22 clade which includes MH Galilee, in Ethiopia and Europe is evidence of second more recent migration of haplogroup J1 separate from the early neolithic J1 migration, consistant with Nebel et al 2000 proposal of Arab expansion of 7th century and represent Arab ancestry[18][19].

It is part of Cohen modal haplotype cluster, which is found in haplogroup J1 sub-clade J1c3d (J1a2b2 ) charactarized by SNP mutation L147.1 which includes YCAII22,22 and is the dominant subclade of haplogroup J1 and is mainly Arabs[20].

Galilee modal haplotype along with its mother clade L147.1 is the DNA test result of majority of Arab males in Arabian Peninsula Y-DNA project which is part of Y-DNA J project [21][22]


discussion

Many similar research been done on persons that predate abraham and fater abraham such as Gengis khan modal haplotype, Aaron modal haplotype(Y-chromosomal Aaron) List_of_haplogroups_of_notable_people MRCA AdamY-chromosomal Adam, etc. there are hundreds of Modale haplotypes connected to persons/dynasties, nations, ect. many of which Klyosov discovered and adjusted such as russian peoples tribes, philippines etc found in the same study about Abraham modal haplotype! this topic of semitic haplogroup mcra is been researched by top scientists of the field such as behar nebel et al mentioning aaron and abraham and are found in pub med as top notch research.the burden of proof in wiki is two references of published material in english. - Many of the references of Klyosov study include Pub Med studies like Nebel et al which mentions Aaron modal haplotype is that of abraham and the Arabs (both arabs and abraham are mentioned by name). - Many of List of haplogroups of notable people are actually modal haplotypes! of notable people. Aaron a desendent of Abraham being separated by small time period they would have same haplogroup/haplotype of (Y chromosomal Aaron also known as Aaron modal haplotype., this is the argument of Klyosov ( a major contributor to the ancestral mutation studies since 2010 in the field of genetic genealogy (the field of the article) he is a superior scientist who made millions in the us because of his scientific discoveries. I will even add more ref that klyosov referenced that are Pub Med and speak of the same thing. others and the fact that Aaron haplotype is the same of the Arabs J1e.]]) - Looking at the wiki Fringe theory the article/studies does not fit under fringe theory: fringe theory is by definition:

  • depart from mainstream(the common current thought of the majority) but (Mainstream of world populaion is that Abraham was the father of Arabs and ancient Israelites including 400 million arabs living today who claim abraham as their father)
  • pseudoscience( not using a valid scientific method) Dna is not pseudoscience, Klyosov did use valid scientific method to calculate the divergence time of Arabs and Jews in J1 and J2 Haplogroups)- No other studies (equal to klyosov in dna studies, or higher) has referenced klyosov study as incorrect.
  • conspiracy theory is used by occult (400 million arabs are not an occult!, Judaism christianity and islam (bible and quran) are not occult (over 2 thirds of the world) even hindu from india believe abraham is the father of Arabs and jews, and many many peoples if not all the world (thus you make the whole world an occult against the minority who believe otherwise( revisionists occults!). why would Arabs who were mentioned as Ishmaelites in Assyrian records in 1000 BC collude with jews at that time 3000 years ago, to claim a common ancestor whose name is Abraham while ,say, his true name is steve, what would they get from such cahoot collusion? ancient bedoin arabs and jews conspired in 1000 BC to claim their father was abraham not steve his real name?. Klyosov calculated the divergence time of jews and arabs and named it Abraham modal haplotype based on historical records and claims (an essential part of genetic genealogy which combines dna study with historical records).

he would have called it Steve modal haplotype. if the historical record /claims his name was steve, same thing with Y-chromosomal Adam, Y-chromosomal Aaron. Klyosov refers to J1-CMH j1-Cohen modal haplotype (Y-chromosomal Aaron ) "it should be called more appropriately the “Abraham Modal Haplotype” when it is exhibited in Jews and Arabs". since most arabs are J1 who have Cohen modal haplotype ( and most j1-cmh (J1-L147.1 sub-haplogroup) is in arabs and all j1-CMH jews are in this subclade), they arabs can't be desendents from Aaron but rather his recent ancestor Abraham. The reason why j1-Cohen modal haplotype was called Y-chromosomal Aaron in the first place is that current jews with cohanim (priestly cast in current judaism/jews claim descent from Aaron!?. The fact the existance of high J1-Cohen modal haplotype in all cohens in all jewish communities even in Tailand (a country devoid of J1 altogether since tailand never experienced arab/islamic invasion) in large percentage can not be a conspiracy theory/ pseudohistory!.

  • Pseudohistory: is dependent on revisionism occult hypothesis conjecture , already clarified as don't fit in mainstream definition and conspiracy theory discussionViibird (talk) 04:09, 14 November 2013 (UTC)


22693781 [23] [24] [25] [26] [27] www.fsijournal.org/article/S0379-0738(05)00615-8/abstract

[28] [29]

references

  1. ^ Klyosov A (2009). "DNA genealogy, Mutation rates, and some historical evidence written in Y-chromosome, Part I: Basic Principles and the Method". Journal of Genetic Genealogy. 5 (2): 198. Origin of peoples in a context of DNA genealogy is an assignment of each of them to a particular tribe or its branch (lineage) initiated in a genealogical sense by a particular ancestor who had a base ("ancestral") haplotype. This also includes an estimation of a time span between the common ancestor and its current descendants. If information obtained this way can be presented in a historical context and supported, even arguably, by other independent archeological, linguistic, historical, ethnographic, anthropological and other related considerations, this can be called a success
  2. ^ Klyosov A (2009). "DNA genealogy, mutation rates, and some historical evidence written in Y-chromosome, Part II: Walking the map". Journal of Genetic Genealogy. 5 (2): 217–256.
  3. ^ Klyosov, Anatole Alex (8 October 2009). "A comment on the paper: Extended Y chromosome haplotypes resolve multiple and unique lineages of the Jewish Priesthood by M.F. Hammer, D.M. Behar, T.M. Karafet, F.L. Mendez, B. Hallmark, T. Erez, L.A. Zhivotovsky, S. Rosset, K. Skorecki, Hum Genet, published online 8 August 2009". Human Genetics. 126 (5): 719–724. doi:10.1007/s00439-009-0739-1.
  4. ^ Klyosov A (2010). "'Origin of the Jews and the Arabs: Date of their most recent common ancestor is written in their Y-chromosomes - However, there were two of them". Nature Precedings.
  5. ^ Nebel, A (2001 Nov). "The Y chromosome pool of Jews as part of the genetic landscape of the Middle East". American journal of human genetics. 69 (5): 1095–112. PMID 11573163. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  6. ^ Nebel (2001), divergence map of Cohan Modal Haplotype Galilee modal haplotype and Israeli Bedoins Modal haplotype, American Journal of Human Genetics
  7. ^ Nebel, A (2002 Jun). "Genetic evidence for the expansion of Arabian tribes into the Southern Levant and North Africa". American journal of human genetics. 70 (6): 1594–6. PMID 11992266. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  8. ^ Hammer MF, Behar DM, Karafet TM, Mendez FL, Hallmark B, Erez T, Zhivotovsky LA, Rosset S, Skorecki K (2009). "Extended Y chromosome haplotypes resolve multiple and unique lineages of the Jewish priesthood". Hum. Genet. 126 (5): 707–17. doi:10.1007/s00439-009-0727-5. PMC 2771134. PMID 19669163. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  9. ^ Klyosov, Anatole Alex (8 October 2009). "A comment on the paper: Extended Y chromosome haplotypes resolve multiple and unique lineages of the Jewish Priesthood by M.F. Hammer, D.M. Behar, T.M. Karafet, F.L. Mendez, B. Hallmark, T. Erez, L.A. Zhivotovsky, S. Rosset, K. Skorecki, Hum Genet, published online 8 August 2009". Human Genetics. 126 (5): 719–724. doi:10.1007/s00439-009-0739-1.
  10. ^ Chiaroni; et al. (14 October 2009). "The emergence of Y-chromosome haplogroup J1e among Arabic-speaking populations". European Journal of Human Genetics. 18 (3): 348–353. doi:10.1038/ejhg.2009.166. PMC 2987219. {{cite journal}}: Explicit use of et al. in: |author= (help)
  11. ^ "Haplogroup J1".
  12. ^ Kleiman Y (2004). DNA and Tradition: The Genetic Link to the Ancient Hebrews. New York: Devora. p. 162. ISBN 1-930143-89-3.
  13. ^ Nebel, A (2000 Dec). "High-resolution Y chromosome haplotypes of Israeli and Palestinian Arabs reveal geographic substructure and substantial overlap with haplotypes of Jews". Human genetics. 107 (6): 630–41. doi:10.1007/s004390000426. PMID 11153918. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  14. ^ Nebel, A (2001 Nov). "The Y chromosome pool of Jews as part of the genetic landscape of the Middle East". American journal of human genetics. 69 (5): 1095–112. doi:10.1086/324070. PMID 11573163. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  15. ^ Nebel (2001), divergence map of Cohan Modal Haplotype Galilee modal haplotype, American Journal of Human Genetics
  16. ^ Nebel, A (2002 Jun). "Genetic evidence for the expansion of Arabian tribes into the Southern Levant and North Africa". American journal of human genetics. 70 (6): 1594–6. doi:10.1086/340669. PMID 11992266. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  17. ^ Nebel, A (2001 Jan). "Haplogroup-specific deviation from the stepwise mutation model at the microsatellite loci DYS388 and DYS392". European journal of human genetics : EJHG. 9 (1): 22–6. PMID 11175295. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  18. ^ Semino, O (2004 May). "Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area". American journal of human genetics. 74 (5): 1023–34. PMID 15069642. {{cite journal}}: Check date values in: |date= (help)
  19. ^ Tofanelli, Sergio (15 April 2009). "J1-M267 Y lineage marks climate-driven pre-historical human displacements". European Journal of Human Genetics. 17 (11): 1520–1524. doi:10.1038/ejhg.2009.58. PMC 1181965.
  20. ^ "Y-DNA Haplogroup J and its Subclades - 2011". ISOGG. Retrieved 18 November 2013.
  21. ^ "Y-DNA J Haplogroup Project". FTDNA. Retrieved 19 November 2013.
  22. ^ "The Arabian Y-DNA J1 Project". genetic genealogy results of males from Arabian peninsula. FTDNA. Retrieved 19 November 2013.
  23. ^ McDonald, J (2012 Spring). "Forensic DNA analysis". Clinical laboratory science : journal of the American Society for Medical Technology. 25 (2): 109–13. PMID 22693781. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  24. ^ Butler, John. [www.cstl.nist.gov/div831/strbase/pub_pres/Butler_coreSTRloci_JFS_Mar2006.pdf "Genetics and Genomics of Core STR Loci Used in Human Identity Testing*"] (PDF). {{cite journal}}: Check |url= value (help); Cite journal requires |journal= (help)
  25. ^ [www.omicsonline.org/2157-7145/2157-7145-3-170.pdf "Genetics and Genomics of Core STR Loci Used in Human Identity Testing*"] (PDF). doi:10.4172/2157-7145.1000170. {{cite journal}}: Check |url= value (help); Cite journal requires |journal= (help)CS1 maint: unflagged free DOI (link)
  26. ^ Redd, AJ (2006 May). "Genetic structure among 38 populations from the United States based on 11 U.S. core Y chromosome STRs". Journal of forensic sciences. 51 (3): 580–5. PMID 16696705. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  27. ^ Hammer, MF (2006 Dec 1). "Population structure of Y chromosome SNP haplogroups in the United States and forensic implications for constructing Y chromosome STR databases". Forensic science international. 164 (1): 45–55. doi:10.1016/j.forsciint.2005.11.013. PMID 16337103. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  28. ^ Redd, AJ (2006 May). "Genetic structure among 38 populations from the United States based on 11 U.S. core Y chromosome STRs". Journal of forensic sciences. 51 (3): 580–5. PMID 16696705. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  29. ^ Sims, LM (2008 Mar). "The golden gene (SLC24A5) differentiates US sub-populations within the ethnically admixed Y-SNP haplogroups" (PDF). Legal medicine (Tokyo, Japan). 10 (2): 72–7. PMID 17720606. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
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