MRC-5: Difference between revisions
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== References == |
== References == |
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==External links== |
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*[http://web.expasy.org/cellosaurus/CVCL_0440 Cellosaurus entry for MRC-5] |
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[[Category:Human cell lines]] |
[[Category:Human cell lines]] |
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Revision as of 12:31, 5 October 2016
MRC-5 (Medical Research Council cell strain 5) is a diploid human cell culture line composed of fibroblasts derived from lung tissue of an 14 week old aborted caucasian male fetus.[1][2] The cell line was isolated by J.P. Jacobs and colleagues in September 1966. [2] [3] [4]
Applications
MRC-5 cells are used to produce several vaccines including MMR, Varicella and Polio. Infected MRC-5 cells secrete the virus, and can be cultured in large volumes suitable for commercial production.
References
- ^ "MRC-5 (ATCC® CCL-171™)". Retrieved 2016-05-19.
- ^ a b "AG05965-D Fibroblast from Skin, Lung". Retrieved 2016-05-19.
- ^ Jacobs, J. P.; Jones, C. M.; Baille, J. P. (1970). "Characteristics of a Human Diploid Cell Designated MRC-5". Nature. 227: 168.
- ^ Jacobs, J. P. (1976). "The Status of Human Diploid Cell Strain MRC-5 as an Approved Substrate for the Production of Viral Vaccines". Journal of Biological Standardization. 4: 97–99.
External links
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