Rudolph E. Tanzi: Difference between revisions
m Dating maintenance tags: {{Cn}} |
→Discoveries and awards: Found study of Tanzi's authorship, cross-reffed this as reprint of first ref |
||
| Line 9: | Line 9: | ||
==Discoveries and awards== |
==Discoveries and awards== |
||
Tanzi discovered (with others) the other two early-onset familial Alzheimer's genes known as the presenilins 1 and 2, in 1995.{{cn|date=October 2016}} |
Tanzi discovered (with others) the other two early-onset familial Alzheimer's genes known as the presenilins 1 and 2, in 1995.{{cn|date=October 2016}} <ref>{{cite journal|last1=Tanzi|first1=R.E.|last2=Zhang|first2=C|last3=Browne|first3=A|last4=Kim|first4=D.Y.|title=Familial Alzheimer’s Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secreted Amyloid-β Protein Precursor Generated by β-Secretase Cleavage|journal=Current Alzheimer's Research|date=Feb 2010|volume=7|issue=1|page=21-26|pmid=3260056|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260056/|accessdate=7 December 2016}}</ref> |
||
Tanzi serves on dozens of editorial and scientific advisory boards, and as Chair of the Cure Alzheimer’s Fund Research Consortium. He has received numerous awards, including the two highest awards for Alzheimer's disease research: The [[Metropolitan Life]] Award and The [[Potamkin Prize]]. He was included on the list of the "Harvard 100 Most Influential Alumni", and was chosen by the Geoffrey Beene Foundation as a “Rock Star of Science”. In 2015, he was named by TIME magazine to the TIME100 Most Influential People in the World list. For his invention of "Alzheimer's-in-a-Dish with Dr. Doo Yeon Kim, in 2015, he and Kim received the Smithsonian American Ingenuity Award, the nation's highest award for invention and innovation. He also received the Silver Innovator Award. |
Tanzi serves on dozens of editorial and scientific advisory boards, and as Chair of the Cure Alzheimer’s Fund Research Consortium. He has received numerous awards, including the two highest awards for Alzheimer's disease research: The [[Metropolitan Life]] Award and The [[Potamkin Prize]]. He was included on the list of the "Harvard 100 Most Influential Alumni", and was chosen by the Geoffrey Beene Foundation as a “Rock Star of Science”. In 2015, he was named by TIME magazine to the TIME100 Most Influential People in the World list. For his invention of "Alzheimer's-in-a-Dish with Dr. Doo Yeon Kim, in 2015, he and Kim received the Smithsonian American Ingenuity Award, the nation's highest award for invention and innovation. He also received the Silver Innovator Award. |
||
Revision as of 06:09, 7 December 2016
Rudolph Tanzi (also Rudy Tanzi) is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University, and Director of the Genetics and Aging Research Unit at Massachusetts General Hospital (MGH).[1] Tanzi has been investigating the genetics of neurological disease since a student in the 1980s when he participated in the first study that used genetic markers to find a disease gene (Huntington's disease). Tanzi co-discovered all three familial early-onset Alzheimer's disease (FAD) genes and several other neurological disease genes including that responsible for Wilson’s disease. As the leader of the Cure Alzheimer's Fund Alzheimer’s Genome Project, Tanzi has carried out multiple genome wide association studies of thousands of Alzheimer’s families leading to the identification of novel AD candidate genes, including CD33 and the first two rare mutations causing late-onset AD in the ADAM10 gene. His research on the role of zinc and copper in AD has led to clinical trials at Prana Biotechnology. He is also working on gamma secretase modulators (together with Steve Wagner, UCSD) for the prevention and treatment of Alzheimer's.
Publications
Dr. Tanzi has published roughly 500 scientific papers including the top three most cited papers in the field of Alzheimer's disease research. Dr. Tanzi also co-authored the books "Decoding Darkness: The Search the Genetic Causes of Alzheimer's Disease, the New York Times Best Seller book “Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being" Paperback – October 22, 2013” and the International best seller: "Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being" with Deepak Chopra. Tanzi has made numerous television appearances on shows such as CBS This Morning and Dr. Oz. He also hosts the shows "Super Brain with Dr. Rudy Tanzi" and "Super Genes with Dr. Rudy Tanzi" on PBS television.
Education
Tanzi received his B.S. in microbiology and B.A.in history from the University of Rochester in 1980. In 1990, he received his Ph.D. in neurobiology at Harvard Medical School, where his doctoral thesis was on the discovery and isolation of the first Alzheimer's disease gene - the amyloid precursor protein (APP), published in 1987 in Science.
Discoveries and awards
Tanzi discovered (with others) the other two early-onset familial Alzheimer's genes known as the presenilins 1 and 2, in 1995.[citation needed] [2]
Tanzi serves on dozens of editorial and scientific advisory boards, and as Chair of the Cure Alzheimer’s Fund Research Consortium. He has received numerous awards, including the two highest awards for Alzheimer's disease research: The Metropolitan Life Award and The Potamkin Prize. He was included on the list of the "Harvard 100 Most Influential Alumni", and was chosen by the Geoffrey Beene Foundation as a “Rock Star of Science”. In 2015, he was named by TIME magazine to the TIME100 Most Influential People in the World list. For his invention of "Alzheimer's-in-a-Dish with Dr. Doo Yeon Kim, in 2015, he and Kim received the Smithsonian American Ingenuity Award, the nation's highest award for invention and innovation. He also received the Silver Innovator Award.
Tanzi was awarded an honorary doctorate from The University of Rhode Island on May 17, 2015.[3]
Music
In musical pursuits, Tanzi professionally plays keyboards, most recently with Joe Perry and Aerosmith.[1] He also co-wrote the song tribute to Alzheimer's patients called "Remember Me", performed by singer Chris Mann.
Bibliography
Books
- Decoding Darkness: The Search for the Genetic Causes of Alzheimer’s Disease. Rudolph E. Tanzi and Ann B, Parson, Perseus Publishing, N.Y. 2000.[4]
- Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being. Deepak Chopra and Rudolph E. Tanzi, Harmony Books, Random House, 2012.[5]
- "Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being." http://www.amazon.com/Super-Genes-Astonishing-Optimum-Well-Being/dp/0804140138/ref=sr_1_1?s=books&ie=UTF8&qid=1451323143&sr=1-1&refinements=p_27%3ARudolph+E.+Tanzi
Key journal articles
- Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX, et al. "Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis."
- Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, Sakaguchi AY, Young AB, Shoulson I, Bonilla E, Martin JB. "A polymorphic DNA marker genetically linked to Huntington's Disease." Nature 1983; 306: 234-238.
- Tanzi, RE, Gusella JF, Watkins PC, Bruns GAP, St. George-Hyslop PH, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL. "The amyloid beta protein gene: cDNA cloning, mRNA distribution, and genetic linkage near the Alzheimer locus." Science 1987; 235: 880-884.
References
- ^ a b Fletcher, Bevin (26 Jun 2015). "Alzheimer's Expert Jams with Aerosmith". Drug Discovery & Development.
- ^ Tanzi, R.E.; Zhang, C; Browne, A; Kim, D.Y. (Feb 2010). "Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secreted Amyloid-β Protein Precursor Generated by β-Secretase Cleavage". Current Alzheimer's Research. 7 (1): 21-26. PMID 3260056. Retrieved 7 December 2016.
- ^ Staff. "Brain scientist "rock star" to address class of 2015". University of Rhode Island. Retrieved 26 Jun 2015.
- ^ "Decoding darkness : the search for the genetic causes of Alzheimer's disease (Book, 2000)". WorldCat. Retrieved 26 Jun 2015.
- ^ "Super brain : unleashing the explosive power of your mind to maximize health, happiness, and spiritual well-being (Book, 2012)". WorldCat. Retrieved 26 Jun 2015.
External links
