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| founded = 2000<ref>https://labiotech.eu/best-funded-biotechs-europe/?utm_referrer=https%3A%2F%2Fwww.google.de%2F</ref>
| founded = 2000<ref>https://labiotech.eu/best-funded-biotechs-europe/?utm_referrer=https%3A%2F%2Fwww.google.de%2F</ref>
| location = [[Tübingen, Germany]]
| location = [[Tübingen, Germany]]
| num_employees = 375<ref name="Official Website - Company">[http://www.curevac.com/company/ "Official Website - Company"]</ref>
| industry = [[Biotechnology]]
| industry = [[Biotechnology]]
| homepage = [http://www.curevac.com// curevac.com]|
| homepage = [http://www.curevac.com// curevac.com]|
}}
}}


'''CureVac''' is a [[biopharmaceutical]] company headquartered in [[Tübingen]], [[Germany]], that develops therapies based on [[messenger RNA]] (mRNA).<ref>''[http://www.fiercebiotech.com/story/industry-voices-mrna-based-therapies-blueprints-therapeutics/2013-07-25 Feature in Fierce Biotech]''</ref> The main research primarily focuses on cancer immunotherapies and prophylactic vaccines against infectious diseases.<ref>{{cite news|title=sp2 Inter-Active|url=http://content.yudu.com/Library/A1yr7l/sp2InterActiveSeptem/resources/34.htm|date=September–October 2012}}</ref> Founded in 2000, CureVac currently has about 240 employees.<ref>{{cite web|title=Gates, Hopp back $110M megaround for CureVac's mRNA work|url=http://www.fiercebiotech.com/story/gates-hopp-back-110m-megaround-curevacs-mrna-work/2015-11-02}}</ref>
'''CureVac''' is a [[biopharmaceutical]] company headquartered in [[Tübingen]], [[Germany]], that develops therapies based on [[messenger RNA]] (mRNA).<ref>''[http://www.fiercebiotech.com/story/industry-voices-mrna-based-therapies-blueprints-therapeutics/2013-07-25 Feature in Fierce Biotech]''</ref> The main research primarily focuses on cancer immunotherapies and prophylactic vaccines against infectious diseases.<ref>{{cite news|title=sp2 Inter-Active|url=http://content.yudu.com/Library/A1yr7l/sp2InterActiveSeptem/resources/34.htm|date=September–October 2012}}</ref> Founded in 2000, CureVac has had about 240 employees in November 2015<ref>{{cite web|title=Gates, Hopp back $110M megaround for CureVac's mRNA work|url=http://www.fiercebiotech.com/story/gates-hopp-back-110m-megaround-curevacs-mrna-work/2015-11-02}}</ref> and 375 in May 2018.<ref name="Official Website - Company"/>


Since inception, CureVac had received approximately $330 million (€300 million) in equity investments.<ref>{{cite web|title=Gates, Hopp back $110M megaround for CureVac's mRNA work|url=http://www.fiercebiotech.com/story/gates-hopp-back-110m-megaround-curevacs-mrna-work/2015-11-02}}</ref> CureVac has entered into various collaborations with multinational corporations and organizations, including agreements with [[Boehringer Ingelheim]], [[Sanofi Pasteur]], [[Johnson & Johnson]], the [[Bill & Melinda Gates Foundation]], [[Eli Lilly and Company]]<ref>{{cite web|last1=Carroll|first1=John|title=Eli Lilly is making a $1.8B leap into the mRNA field, targeting next-gen cancer vaccines|url=https://endpts.com/eli-lilly-is-making-a-1-8b-leap-into-the-mrna-field-targeting-next-gen-cancer-vaccines/|website=endpts.com|date=18 October 2017}}</ref> and the [[International AIDS Vaccine Initiative]].<ref>{{cite web|title=CureVac Opens up an mRNA Hub in Moderna’s Cambridge Backyard |url=http://www.xconomy.com/boston/2015/09/10/curevac-opens-up-an-mrna-hub-in-modernas-cambridge-backyard}}</ref>
Since inception, CureVac had received approximately $330 million (€300 million) in equity investments.<ref>{{cite web|title=Gates, Hopp back $110M megaround for CureVac's mRNA work|url=http://www.fiercebiotech.com/story/gates-hopp-back-110m-megaround-curevacs-mrna-work/2015-11-02}}</ref> CureVac has entered into various collaborations with multinational corporations and organizations, including agreements with [[Boehringer Ingelheim]], [[Sanofi Pasteur]], [[Johnson & Johnson]], the [[Bill & Melinda Gates Foundation]], [[Eli Lilly and Company]]<ref>{{cite web|last1=Carroll|first1=John|title=Eli Lilly is making a $1.8B leap into the mRNA field, targeting next-gen cancer vaccines|url=https://endpts.com/eli-lilly-is-making-a-1-8b-leap-into-the-mrna-field-targeting-next-gen-cancer-vaccines/|website=endpts.com|date=18 October 2017}}</ref> and the [[International AIDS Vaccine Initiative]].<ref>{{cite web|title=CureVac Opens up an mRNA Hub in Moderna’s Cambridge Backyard |url=http://www.xconomy.com/boston/2015/09/10/curevac-opens-up-an-mrna-hub-in-modernas-cambridge-backyard}}</ref>

Revision as of 08:04, 9 May 2018

CureVac AG[1]
Company typePrivate
IndustryBiotechnology
Founded2000[2]
HeadquartersTübingen, Germany
Number of employees
375[3]
Websitecurevac.com

CureVac is a biopharmaceutical company headquartered in Tübingen, Germany, that develops therapies based on messenger RNA (mRNA).[4] The main research primarily focuses on cancer immunotherapies and prophylactic vaccines against infectious diseases.[5] Founded in 2000, CureVac has had about 240 employees in November 2015[6] and 375 in May 2018.[3]

Since inception, CureVac had received approximately $330 million (€300 million) in equity investments.[7] CureVac has entered into various collaborations with multinational corporations and organizations, including agreements with Boehringer Ingelheim, Sanofi Pasteur, Johnson & Johnson, the Bill & Melinda Gates Foundation, Eli Lilly and Company[8] and the International AIDS Vaccine Initiative.[9]

Technology

CureVac’s technology platform was developed in the late 1990s from the research conducted by Ingmar Hoerr and colleagues in the laboratories of Professor Hans-Georg Rammensee and Professor Günther Jung at University of Tübingen in Germany.[10] CureVac's technology platform utilizes natural, chemically unmodified mRNA, which studies have shown elicits great therapeutic responses.[11]

The basic principle of the company's proprietary technology is the use of mRNA as a data carrier to instruct the human body to produce its own proteins capable of fighting a wide range of diseases.[12] Since 2008, CureVac has applied its mRNA technology in more than 350 humans in seven clinical trials in eleven countries, including an ongoing Phase IIb trial in prostate cancer.[13]

In 2006, CureVac successfully established the first GMP facility worldwide for the manufacturing of mRNA for medical purposes.[14] In 2016 CureVac will start the construction of an industrial scale production facility with a capacity of 30 million doses per year.[15]

Research

Researchers from CureVac published data in Nature Biotechnology in 2012, which highlighted an experimental RNA vaccine approach for longer protection from flu.[16]

In June 2015, CureVac announced that a study of its RNArt technology platform was published in the peer-reviewed journal Molecular Therapy, demonstrating for the first time ever that sequence-optimized, chemically unmodified mRNAs raised relevant protein levels in non-human primates without stimulating unwanted immune reaction, indicating that mRNA achieves meaningful biological effects in large animals with body weight close to humans.[17] The study also suggested that sequence-optimized, unmodified mRNAs offer advantages when compared to chemically-modified mRNAs, including more efficacious protein translation.[18]

In July 2015, CureVac announced a publication in the peer-reviewed Journal for ImmunoTherapy of Cancer highlighting a Phase I/IIa study of the company’s mRNA cancer immunotherapy CV9103 in advanced castration-resistant prostate cancer. The data showed the first Phase IIa clinical study in which an mRNA therapy has demonstrated antigen-specific immune responses in the majority of patients.[19]

History

In October 2013 Curevac launched a collaboration with Janssen Pharmaceuticals Inc., a Johnson & Johnson company, for the development of novel flu vaccines.[20]

In November 2013, CureVac announced the fourth in a series of partnerships with the Cancer Research Institute and Ludwig Cancer Research to enable clinical testing of novel cancer immunotherapy treatment options.[21]

On March 10, 2014, CureVac won a €2 million prize awarded by the European Commission to stimulate new vaccine technologies that might help the developing world, because the company's research could lead to a new generation of vaccines that don't need refrigeration.[22]

In July 2014, CureVac signed an exclusive license agreement with Sanofi Pasteur to develop and commercialize an mRNA-based prophylactic vaccine.[23]

In September 2014 the company licensed the global rights for its Phase I candidate – CV9202 – to Boehringer Ingelheim. Boehringer plans to conduct trials using the mRNA vaccine in combination with afatinib in advanced and/or metastatic epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC) as well as inoperable stage III NSCLC. This could culminate in netting the company approximately $600 million.[24]

In March 2015, CureVac’s investor, the Bill & Melinda Gates Foundation, agreed to provide separate funding for several projects to develop prophylactic vaccines based on CureVac’s proprietary mRNA platform.[25]

In September 2015, CureVac entered into a collaboration with the International AIDS Vaccine Initiative (IAVI) to accelerate the development of AIDS vaccines, utilizing immunogens developed by IAVI and partners, delivered via CureVac’s mRNA technology.[26]

In September 2015, CureVac announced it would be opening a United States hub in Cambridge, Massachusetts.[27]

References

  1. ^ http://www.curevac.com/contact/
  2. ^ https://labiotech.eu/best-funded-biotechs-europe/?utm_referrer=https%3A%2F%2Fwww.google.de%2F
  3. ^ a b "Official Website - Company"
  4. ^ Feature in Fierce Biotech
  5. ^ "sp2 Inter-Active". September–October 2012.
  6. ^ "Gates, Hopp back $110M megaround for CureVac's mRNA work".
  7. ^ "Gates, Hopp back $110M megaround for CureVac's mRNA work".
  8. ^ Carroll, John (18 October 2017). "Eli Lilly is making a $1.8B leap into the mRNA field, targeting next-gen cancer vaccines". endpts.com.
  9. ^ "CureVac Opens up an mRNA Hub in Moderna's Cambridge Backyard".
  10. ^ "In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies". Eur J Immunol. 30 (1): 1–7. Jan 2000. doi:10.1002/1521-4141(200001)30:1<1::AID-IMMU1>3.0.CO;2-#. PMID 10602021.
  11. ^ "Sequence Engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals". Mol Ther. 23 (9): 1456–1464. Sep 2015. doi:10.1038/mt.2015.103.
  12. ^ "Conversation on CureVac's RNA-Based Therapeutics with CEO Ingmar Hoerr".
  13. ^ "Vantage Point – The messenger comes calling".
  14. ^ "German RNA Vaccines Company Bags €2 Million E.U. Vaccine Prize".
  15. ^ "Vantage Point – The messenger comes calling".
  16. ^ Petsch, B; Schnee, M; Vogel, AB; et al. (Dec 2012). "Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection". Nat Biotechnol. 30 (12): 1210–1216. doi:10.1038/nbt.2436. PMID 23159882. {{cite journal}}: Explicit use of et al. in: |last4= (help)
  17. ^ "Sequence Engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals". Mol Ther. 23 (9): 1456–1464. Sep 2015. doi:10.1038/mt.2015.103.
  18. ^ "Sequence Engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals". Mol Ther. 23 (9): 1456–1464. Sep 2015. doi:10.1038/mt.2015.103.
  19. ^ "Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study". JITC. 3 (26). June 2015.
  20. ^ "J&J's Janssen Companies Launch a Trio of Collaborations".
  21. ^ "CRI, Ludwig to Test Cancer Immunotherapy Combinations with CureVac".
  22. ^ "German RNA Vaccines Company Bags €2 Million E.U. Vaccine Prize".
  23. ^ "CureVac, Sanofi Paster in 150m-euro-plus vaccines deal".
  24. ^ "Boehringer pairs its lung cancer drug with a vaccine in $600M tie-up with CureVac".
  25. ^ "Bill And Melinda Gates Foundation Makes Its Largest Ever Equity Investment In A Biotech Company".
  26. ^ "IAVI and CureVac partner to further AIDS vaccine candidates".
  27. ^ "CureVac Opens up an mRNA Hub in Moderna's Cambridge Backyard | Xconomy". Xconomy. 2015-09-10. Retrieved 2017-06-09.
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