Talk:Angiotensin-converting enzyme 2

Treatment with angiotensin-converting enzyme (ACE) inhibitors results in an upregulation of ACE2,[23]

Can anybody actually find that statement in reference 23?

Is there a difference (in this context) between "ACE2" and "ACE2 receptor"?

Recent additions to this article indirectly claim that there is a difference between "ACE2" and "ACE2 receptor". I very much doubt this is the case. All the literature I have read on related subjects treat those terms interchangeably and/or describe them in the same terms.--Dpratt71 (talk) 16:52, 17 March 2020 (UTC)

"ACE2 receptor" makes no sense. ACE2 is ITSELF the receptor for SARS-CoV and SARS-CoV-2 on respiratory tract cells. In normal function, ACE2 = angiotensin converting enzyme 2 "catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1–9][5] or the conversion of angiotensin II to angiotensin 1–7.[6][7]". --Canavalia (talk) 19:29, 17 March 2020 (UTC)

That was my understanding, thank you for confirming, Canavalia. To further clarify, I think the term "ACE2 receptor" makes sense, it's just a bit redundant. The "ACE2 receptor" is not a receptor for ACE2, ACE2 is the receptor, as you say. As such, I believe this statement in the article is in error and should be removed (along with any corresponding edits):

This might lead some to suggest that decreasing the levels of ACE2, in cells, might help in fighting the infection, but that conflates ACE2 with the ACE2 receptor.

I'd vastly prefer someone with more subject knowledge make that edit (or at least someone with more WP editing knowledge), but I may get up the nerve to do it otherwise. --Dpratt71 (talk) 18:15, 17 March 2020 (UTC)