Jump to content

Biological value: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
rv - vandalism by sockpuppet of blocked user
reverted blanking by Yankees76 for no valid reason. Removing references is considered vandalism. Please refrain from removing references.
Line 1: Line 1:
{{NPOV}}
'''Biological Value''' or BV is a common method for measuring protein quality and biological utilization rates of [[protein]] for human and animal consumption. The method relies on [[nitrogen]] retention as an indicator of protein quality. Unlike [[carbohydrates]] and [[fats]], all protein contains nitrogen. Scientists trace nitrogen as it enters the body through protein intake and measure the amount that is retained. Since protein is used in the construction of bodily cells, the more protein that is retained indicates a higher level of biological utilization of the particular protein. The more nitrogen that is excreted as urine and fecal matter, the less utilizable the particular kind of protein.
'''Biological Value''' or BV is a common method for measuring protein quality and biological utilization rates of [[protein]] for human and animal consumption. The method relies on [[nitrogen]] retention as an indicator of protein quality. Unlike [[carbohydrates]] and [[fats]], all protein contains nitrogen. Scientists trace nitrogen as it enters the body through protein intake and measure the amount that is retained. Since protein is used in the construction of bodily cells, the more protein that is retained indicates a higher level of biological utilization of the particular protein. The more nitrogen that is excreted as urine and fecal matter, the less utilizable the particular kind of protein.


Line 12: Line 11:
A BV of 100 would indicate complete utilization of a given dietary protein, in that 100% of the protein ingested was stored in the body with none lost. However, it is physically impossible to have a BV greater than 100, because that would mean that more than 1 gram of nitrogen was stored for every 1 gram of nitrogen consumed.
A BV of 100 would indicate complete utilization of a given dietary protein, in that 100% of the protein ingested was stored in the body with none lost. However, it is physically impossible to have a BV greater than 100, because that would mean that more than 1 gram of nitrogen was stored for every 1 gram of nitrogen consumed.


[[egg (biology)|Egg]] protein scored the highest number of 100 to serve as a measuring stick, though by some sources, it is scored as 93.7.<ref>Food and Agriculture Organization of the United Nations. The Amino Acid Content of Foods and Biological Data on Proteins. Nutritional Study #24. Rome (1970). UNIPUB, Inc., 4611-F Assembly Drive, Lanham, MD 20706</ref> This is because [[whey protein]] has subsequently been found to have the highest known biological value of any protein in humans.<ref>[http://www.lef.org/magazine/mag98/oct98_report2.html LE Magazine October 1998 Unlocking the Secrets to Health & Fitness].</ref> As a result whey protein proponents have dropped the percentage sign on BV and extended the scale beyond 100. This is why some sources list whey as having a BV 104, even though as noted above, it is physically impossible.
[[egg (biology)|Egg]] protein scored the highest number of 100 to serve as a measuring stick, though by some sources, it is scored as 93.7.<ref>Food and Agriculture Organization of the United Nations. The Amino Acid Content of Foods and Biological Data on Proteins. Nutritional Study #24. Rome (1970). UNIPUB, Inc., 4611-F Assembly Drive, Lanham, MD 20706</ref> This is because [[whey protein]] has subsequently been found to have the highest known biological value of any protein in humans.<ref>[http://www.lef.org/magazine/mag98/oct98_report2.html LE Magazine October 1998 Unlocking the Secrets to Health & Fitness].</ref> As a result whey protein proponents have dropped the percentage sign on BV and extended the scale beyond 100. This is why some sources list whey as having a BV 104, even though as noted above, it is physically impossible.{{fact}} Now whey has the highest possible BV at 100.


==Animals==
==Animals==
Line 18: Line 17:
The Biological Value method is also used for analysis in animals such as cattle, poultry, and various laboratory animals such as rats. It was used by the poultry industry to determine which mixtures of feed were utilized most efficiently by developing chicken.
The Biological Value method is also used for analysis in animals such as cattle, poultry, and various laboratory animals such as rats. It was used by the poultry industry to determine which mixtures of feed were utilized most efficiently by developing chicken.
Although the process remains the same, the biological values of particular proteins in humans differs from their biological values in animals due to physiological variations.<ref>[http://www.fao.org/docrep/U5900t/u5900t07.htm Recent developments in protein quality evaluation by Dr E. Boutrif].</ref>
Although the process remains the same, the biological values of particular proteins in humans differs from their biological values in animals due to physiological variations.<ref>[http://www.fao.org/docrep/U5900t/u5900t07.htm Recent developments in protein quality evaluation by Dr E. Boutrif].</ref>

==Advantages ==

The BV and [[PDCAAS]] is more relevant than the [[Protein efficiency ratio|Protein Efficiency Ratio]] (PER) for the measurement of protein utilization in humans.<ref name=Methodology>Thomas, K. Ueber die biologische Wertigkeit der stickstoff-substanzen in 1909 verschiedenen Nahrungsmitteln. Arch. Physiol., 219.</ref><ref name=BVisBest>Mitchell, H.H. A method for determining the biological value of protein. 1924 J. Biol. Chem., 58, 873.</ref><ref name=BVisSuperior>Mitchell, H.H. and G.G. Carman. The biological value of the nitrogen of mixtures 1926 of patent white flour and animal foods. J. Biol. Chem., 68, 183.</ref><ref name=Researchers>Optimum Sports Nutrition: Your Competitive Edge, A Complete Nutritional Guide For Optimizing Athletic Performance; Chapter 12. by Dr. Michael Colgan</ref><ref>http://www.afpafitness.com/articles/AnimalvsVegetable.htm The Great Animal Versus Vegetable Protein Debate What Is The Best Protein For Muscle Growth?</ref><ref name=Proteins>[http://www.fao.org/DOCREP/MEETING/004/M2835E/M2835E00.HTM The Use Of Biological Value Of A Protein In Evaluting Its Quality For Human Requirments]</ref>

The table below shows the Biological Value rating of various common proteins.

*Isolated Whey: 100 or 104<ref>[http://www.maxmuscle.com/index.cfm?fa=article&doc_id=397&subcat=sports_nutrition Whey Protein with Dorian Yates By Dorian Yates: Table System]</ref><ref>Protein Quality-Report of Joint FAO’/WHO Expert Consultation, Food and Agriculture Organisation, Rome, FAO Food and Nutrition Paper 51, 1991.</ref><ref>Renner E; Milk and dairy products in human nutrition. Volkswirtsch. Verlag, Munchen, 1983.</ref><ref>Food and Agriculture Organization of the United Nations. The Amino Acid Content of Foods and Biological Data on Proteins. Nutritional Study #24. Rome (1970). UNIPUB, Inc., 4611-F Assembly Drive, Lanham, MD 20706 [http://www.iowaegg.org/allabouteggs/biological-value.html Table]</ref>
*Whole Egg: 100 or 93.7
*Cow’s Milk: 91
*Egg Whites: 88
*Fish: 83
*Casein: 80
*Beef: 80
*Chicken: 79
*Soy: 74
*Wheat Gluten: 54
*Kidney Beans: 49


==Critics==
==Critics==
Line 42: Line 59:
Regardless, the scientific community has raised critical questions about the validity of PDCAAS.{{Specify|date=December 2006}}<ref>Gertjan Schaafsma; Center of Expertise Nutrition, DMV International-Campina Melkunie, 6700 AA, Wageningen, the Netherlands The Protein Digestibility-Corrected Amino Acid Score -- Journal of Nutrition. 2000;130(7):1865S-1867S. [http://jn.nutrition.org/cgi/content/full/130/7/1865S The Journal of Nutrition]</ref><ref>Darragh A. J., Schaafsma G., and Moughan P. J. Impact of amino acid availability on the protein digestibility corrected amino acid score. Proceedings of the Nutrition Week of the International Dairy Federation, Wellington, New Zealand, March 9–11, 1998 1998</ref><ref>Dutch Dairy Foundation on Nutrition and Health Proceedings of the International Workshop on Nutritional Aspects of Milk Proteins in Comparison with Other Proteins, organized by the Dutch Foundation on Nutrition and Health, Utrecht, the Netherlands, March 13–14, 1995</ref>
Regardless, the scientific community has raised critical questions about the validity of PDCAAS.{{Specify|date=December 2006}}<ref>Gertjan Schaafsma; Center of Expertise Nutrition, DMV International-Campina Melkunie, 6700 AA, Wageningen, the Netherlands The Protein Digestibility-Corrected Amino Acid Score -- Journal of Nutrition. 2000;130(7):1865S-1867S. [http://jn.nutrition.org/cgi/content/full/130/7/1865S The Journal of Nutrition]</ref><ref>Darragh A. J., Schaafsma G., and Moughan P. J. Impact of amino acid availability on the protein digestibility corrected amino acid score. Proceedings of the Nutrition Week of the International Dairy Federation, Wellington, New Zealand, March 9–11, 1998 1998</ref><ref>Dutch Dairy Foundation on Nutrition and Health Proceedings of the International Workshop on Nutritional Aspects of Milk Proteins in Comparison with Other Proteins, organized by the Dutch Foundation on Nutrition and Health, Utrecht, the Netherlands, March 13–14, 1995</ref>


On the other hand, BV makes a differentiation with respect to proteins with similar protein values such as egg whites at 88, whole eggs at 100, and whey at 104. Even though, as noted above it is thermodynamically impossible to achieve a BV of over 100.
On the other hand, BV makes a differentiation with respect to proteins with similar protein values such as egg whites at 88, cow's milk at 91, and whole eggs at 100.


Biological Value (BV), as demonstrated by research scientists - including early 20th century scientists K. Thomas, and H.H. Mitchell - is another method of choice as to estimating the nutritive value of proteins for muscle growth and synthesis.<ref name=Methodology/><ref name=BVisBest/><ref name=BVisSuperior/><ref name=Researchers/><ref name=Proteins/> Some athletes and Dr. [[Michael Colgan]] also support BV as a reliable method for protein value.<ref name=Researchers/>
Biological Value (BV), as demonstrated by research scientists - including early 20th century scientists K. Thomas, and H.H. Mitchell - is another method of choice as to estimating the nutritive value of proteins for muscle growth and synthesis.<ref name=Methodology/><ref name=BVisBest/><ref name=BVisSuperior/><ref name=Researchers/><ref name=Proteins/> Some athletes and Dr. [[Michael Colgan]] also support BV as a reliable method for protein value.<ref name=Researchers/>

Revision as of 16:27, 1 January 2007

Biological Value or BV is a common method for measuring protein quality and biological utilization rates of protein for human and animal consumption. The method relies on nitrogen retention as an indicator of protein quality. Unlike carbohydrates and fats, all protein contains nitrogen. Scientists trace nitrogen as it enters the body through protein intake and measure the amount that is retained. Since protein is used in the construction of bodily cells, the more protein that is retained indicates a higher level of biological utilization of the particular protein. The more nitrogen that is excreted as urine and fecal matter, the less utilizable the particular kind of protein.

The number is expressed as a score with 100 being the threshold. The number progressively lowers as more is consumed,[1] while the protein's score is based on its consumption in a fasted state.

Humans

Biological Value is a relevant method for the measurement of protein utilization in humans.[2][3][4][5][6][7] Biological value is determined based this formula.

BV = (nitrogen retained / nitrogen absorbed) * 100

A BV of 100 would indicate complete utilization of a given dietary protein, in that 100% of the protein ingested was stored in the body with none lost. However, it is physically impossible to have a BV greater than 100, because that would mean that more than 1 gram of nitrogen was stored for every 1 gram of nitrogen consumed.

Egg protein scored the highest number of 100 to serve as a measuring stick, though by some sources, it is scored as 93.7.[8] This is because whey protein has subsequently been found to have the highest known biological value of any protein in humans.[9] As a result whey protein proponents have dropped the percentage sign on BV and extended the scale beyond 100. This is why some sources list whey as having a BV 104, even though as noted above, it is physically impossible.[citation needed] Now whey has the highest possible BV at 100.

Animals

The Biological Value method is also used for analysis in animals such as cattle, poultry, and various laboratory animals such as rats. It was used by the poultry industry to determine which mixtures of feed were utilized most efficiently by developing chicken. Although the process remains the same, the biological values of particular proteins in humans differs from their biological values in animals due to physiological variations.[10]

Advantages

The BV and PDCAAS is more relevant than the Protein Efficiency Ratio (PER) for the measurement of protein utilization in humans.[2][3][4][5][11][7]

The table below shows the Biological Value rating of various common proteins.

  • Isolated Whey: 100 or 104[12][13][14][15]
  • Whole Egg: 100 or 93.7
  • Cow’s Milk: 91
  • Egg Whites: 88
  • Fish: 83
  • Casein: 80
  • Beef: 80
  • Chicken: 79
  • Soy: 74
  • Wheat Gluten: 54
  • Kidney Beans: 49

Critics

Since the method measures only the amount that is retained in the body critics have pointed out what they perceive as a weakness of the biological value methodology.[16] Critics have pointed to research that indicates that because whey protein isolate is digested so quickly it may in fact enter the bloodstream and be converted into carbohydrates through a process called gluconeogenesis much more rapidly than was previously thought possible, so while amino acid concentrations increased with whey it was discovered that oxidation rates also increased and a steady-state metabolism where there is no change in overall protein balance is created.[17] They claim that when the human body consumes whey protein it is absorbed so rapidly that most of it is sent to the liver for oxidation. Hence they believe the reason so much is retained is that it is used for energy production not protein synthesis. This would bring into question whether the method defines which proteins are more biologically utilizable.

A further critique published in the Journal of Sports Science and Medicine, states that BV of a protein does not take into consideration several key factors that influence the digestion and interaction of protein with other foods before absorption, and that it only measures a proten's maximal potential quality and not its estimate at requirement levels.[18] Also, the study by Poullain et al, which is often cited to demonstrate the superiority of whey protein hydrosylate by marketers, measured nitrogen balance in rats after three days of starvation, which corresponds to a longer period in humans [19]. The study found that whey protein hydrosylate led to better nitrogen retention and growth than the other proteins studied. However the study's flaw is in the BV method used, as starvation affects how well the body will store incoming protein (as does a very high caloric intake), leading to falsely elevated BV measures. [20]

So, the BV of a protein is related to the amount of protein given. BV is measured at levels below the maintenance level. This means that as protein intake goes up, the BV of that protein goes down. For example, milk protein shows a BV near 100 at intakes of 0.2 g/kg. As protein intake increases to roughly maintenance levels, 0.5 g/kg, BV drops only around 70.Cite error: A <ref> tag is missing the closing </ref> (see the help page).

Another limitation of the use of Biological Value as a measure of protein quality is that proteins which are completely devoid of one essential amino acid (EAA) can still have a BV of up to 40. This is because a the ability of ogranisms conserve and recycle EAA as an adaptation of inadequate intake of the amino acid. [21]

Lastly, the use of rats for the determination of protein quality is not ideal. Rats differ from humans in requirements of essential amino acids. This has lead to a general criticism that experiments on rats lead to an over-estimation of the BV of high-quality proteins to man because human requirements of essential amino acids are much lower than those for rats (as rats grow at a much faster rate than humans). Also, because of their fur, rats are assumed to have relatively high requirements of sulphur-containing amino acids (methionine and cystine).

As a result, the analytical method that is universally recognized by the FAO/WHO as well as the FDA, USDA, United Nations University (UNU) and the National Academy of Sciences when judging the quality of protein in the human is not PER or BV but the Protein Digestibility Corrected Amino Acid Score (PDCAAS), as it is viewed as accurately measuring the correct relative nutritional value of animal and vegetable sources of protein in the diet.[22][23] However, scientific studies demonstrate PDCAAS scale has limitations in predicting protein quality of those protein sources which may contain naturally occurring growth-depressing factors or antinutritional factors formed during alkaline and/or heat processing. In short, PDCAAS makes no distinction of their peformance relative to each other because after they pass a certain point they are all capped at 1.0 being the highest possible score and receive an identical rating.[24][25][26] This is because in 1990 at a FAO/WHO meeting it was decided that proteins having values higher than 1.0 would be rounded or "leveled down" to 1.0 as scores above 1.0 are considered to indicate that the protein contains essential amino acids in excess of the human requirements. [27] This approach implies injustice to high-quality proteins which can compensate for low-quality ones by virtue of their high content of essential amino acids (egg has an actual PDCAA score of 1.19 compared to 0.91 for soy, however when leveled down, they appear much closer).[28]

Regardless, the scientific community has raised critical questions about the validity of PDCAAS.[specify][29][30][31]

On the other hand, BV makes a differentiation with respect to proteins with similar protein values such as egg whites at 88, cow's milk at 91, and whole eggs at 100.

Biological Value (BV), as demonstrated by research scientists - including early 20th century scientists K. Thomas, and H.H. Mitchell - is another method of choice as to estimating the nutritive value of proteins for muscle growth and synthesis.[2][3][4][5][7] Some athletes and Dr. Michael Colgan also support BV as a reliable method for protein value.[5]

References

  1. ^ Protein Fundamentals - Part 3 Quality Determinants by Donald G. Snyder, Ph.D. This article is sponsored by Proper Nutrition, a proprietary company
  2. ^ a b c Thomas, K. Ueber die biologische Wertigkeit der stickstoff-substanzen in 1909 verschiedenen Nahrungsmitteln. Arch. Physiol., 219.
  3. ^ a b c Mitchell, H.H. A method for determining the biological value of protein. 1924 J. Biol. Chem., 58, 873.
  4. ^ a b c Mitchell, H.H. and G.G. Carman. The biological value of the nitrogen of mixtures 1926 of patent white flour and animal foods. J. Biol. Chem., 68, 183.
  5. ^ a b c d Optimum Sports Nutrition: Your Competitive Edge, A Complete Nutritional Guide For Optimizing Athletic Performance; Chapter 12. by Dr. Michael Colgan
  6. ^ http://www.afpafitness.com/articles/AnimalvsVegetable.htm The Great Animal Versus Vegetable Protein Debate What Is The Best Protein For Muscle Growth?
  7. ^ a b c The Use Of Biological Value Of A Protein In Evaluting Its Quality For Human Requirments
  8. ^ Food and Agriculture Organization of the United Nations. The Amino Acid Content of Foods and Biological Data on Proteins. Nutritional Study #24. Rome (1970). UNIPUB, Inc., 4611-F Assembly Drive, Lanham, MD 20706
  9. ^ LE Magazine October 1998 Unlocking the Secrets to Health & Fitness.
  10. ^ Recent developments in protein quality evaluation by Dr E. Boutrif.
  11. ^ http://www.afpafitness.com/articles/AnimalvsVegetable.htm The Great Animal Versus Vegetable Protein Debate What Is The Best Protein For Muscle Growth?
  12. ^ Whey Protein with Dorian Yates By Dorian Yates: Table System
  13. ^ Protein Quality-Report of Joint FAO’/WHO Expert Consultation, Food and Agriculture Organisation, Rome, FAO Food and Nutrition Paper 51, 1991.
  14. ^ Renner E; Milk and dairy products in human nutrition. Volkswirtsch. Verlag, Munchen, 1983.
  15. ^ Food and Agriculture Organization of the United Nations. The Amino Acid Content of Foods and Biological Data on Proteins. Nutritional Study #24. Rome (1970). UNIPUB, Inc., 4611-F Assembly Drive, Lanham, MD 20706 Table
  16. ^ Joint FAO/WHO/UNU Expert Consultation on Energy and Protein Requirements, The use of biological value of protein in evaluatiing its quality for human requirements, S.G. Srikantia, University of Mysore.
  17. ^ Testosterone Nation, The Protein Roundtable, August 24, 2000.
  18. ^ Journal of Sports Science and Medicine (2004) 3, 118-130
  19. ^ Poullain, MG et. al. Effect of whey proteins, their oligopeptide hydrosylates and free amino acid mixtures on growth and nitrogen retention in fed and starved rats. J Parenteral and Enteral Nutrition (1989) 13: 382-386
  20. ^ Pellett, PL and Young, VR. Nutritional evaluation of protein foods. United Nations University, 1980.
  21. ^ Said, A.K. and Hegsted, D.M., J. Nutr., 99, 474, 1969
  22. ^ FAO/WHO (1991) Protein Quality Evaluation Report of Joint FAO/WHO Expert Consultation, Food and Agriculture Organization of the United Nations, FAO Food and Nutrition Paper No. 51, Rome.
  23. ^ Schaafsma, G. (2000) 'The protein digestibility-corrected amino acid score. Journal of Nutrition 130, 1865S-1867S
  24. ^ The Journal of Sports Science and Medicine (2004) 3, 118-130..
  25. ^ Sarwar G. Health Canada, Bureau of Nutritional Sciences, Banting Research Centre, Ottawa, Ontario. The protein digestibility-corrected amino acid score method overestimates quality of proteins containing antinutritional factors and of poorly digestible proteins supplemented with limiting amino acids in rats. J Nutr. 1997 May;127(5):758-64. Pub Med Reference
  26. ^ Schaafsma G. TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist, The Netherlands. The Protein Digestibility-Corrected Amino Acid Score (PDCAAS)--a concept for describing protein quality in foods and food ingredients: A Critical Review. J AOAC Int. 2005 May-Jun;88(3):988-94. The Validity Of PDCAAS Under Critical Review
  27. ^ FAO/WHO [1990]. Expert consultation on protein quality evaluation. Food and Agriculture Organization of the United Nations, Rome.
  28. ^ FAO/WHO/UNU [1985]. Expert consultation. Energy and protein requirements. Technical Report Series 724. World Health Organization, Geneva.
  29. ^ Gertjan Schaafsma; Center of Expertise Nutrition, DMV International-Campina Melkunie, 6700 AA, Wageningen, the Netherlands The Protein Digestibility-Corrected Amino Acid Score -- Journal of Nutrition. 2000;130(7):1865S-1867S. The Journal of Nutrition
  30. ^ Darragh A. J., Schaafsma G., and Moughan P. J. Impact of amino acid availability on the protein digestibility corrected amino acid score. Proceedings of the Nutrition Week of the International Dairy Federation, Wellington, New Zealand, March 9–11, 1998 1998
  31. ^ Dutch Dairy Foundation on Nutrition and Health Proceedings of the International Workshop on Nutritional Aspects of Milk Proteins in Comparison with Other Proteins, organized by the Dutch Foundation on Nutrition and Health, Utrecht, the Netherlands, March 13–14, 1995
Retrieved from "https://en.wikipedia.org/w/index.php?title=Biological_value&oldid=97742936"