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The main cause of gynecomastia is an imbalance between estrogen and androgen varying from increase in estrogen production, decrease in androgen production, or a combination of both. <ref>{{Cite journal|last=Dickson|first=Gretchen|date=2012-04-01|title=Gynecomastia|url=https://www.aafp.org/afp/2012/0401/p716.html|journal=American Family Physician|volume=85|issue=7|pages=716–722|issn=0002-838X}}</ref>

An abnormal ratio of myo-inositol and D-chiro-inositol can be present in PCOS affecting estrogen and androgen levels. In PCOS, MI concentrations are depleted; affecting glucose intake and impairing FSH signaling needed for ovulation. DCI concentrations are increased, leading to an overproduction of androgens. Research shows that a combination of 40:1 molar ratio of myo-inositol (MI) and d-chiro-insositol (DCI) can improve metabolic and hormonal imbalances in PCOS. <ref>{{Cite journal|last=Unfer|first=Vittorio|last2=Dinicola|first2=Simona|last3=Laganà|first3=Antonio Simone|last4=Bizzarri|first4=Mariano|date=2020/1|title=Altered Ovarian Inositol Ratios May Account for Pathological Steroidogenesis in PCOS|url=https://www.mdpi.com/1422-0067/21/19/7157|journal=International Journal of Molecular Sciences|language=en|volume=21|issue=19|pages=7157|doi=10.3390/ijms21197157}}</ref>

Welcome to my sandbox!
Welcome to my sandbox!






Latest revision as of 04:29, 9 November 2020

The main cause of gynecomastia is an imbalance between estrogen and androgen varying from increase in estrogen production, decrease in androgen production, or a combination of both. [1]

An abnormal ratio of myo-inositol and D-chiro-inositol can be present in PCOS affecting estrogen and androgen levels. In PCOS, MI concentrations are depleted; affecting glucose intake and impairing FSH signaling needed for ovulation. DCI concentrations are increased, leading to an overproduction of androgens. Research shows that a combination of 40:1 molar ratio of myo-inositol (MI) and d-chiro-insositol (DCI) can improve metabolic and hormonal imbalances in PCOS. [2]

Welcome to my sandbox!


I am currently learning how to use wikipedia for my course. I am nervous about making edits and correcting work on a public domain. Hopefully, I become more confident.

  1. ^ Dickson, Gretchen (2012-04-01). "Gynecomastia". American Family Physician. 85 (7): 716–722. ISSN 0002-838X.
  2. ^ Unfer, Vittorio; Dinicola, Simona; Laganà, Antonio Simone; Bizzarri, Mariano (2020/1). "Altered Ovarian Inositol Ratios May Account for Pathological Steroidogenesis in PCOS". International Journal of Molecular Sciences. 21 (19): 7157. doi:10.3390/ijms21197157. {{cite journal}}: Check date values in: |date= (help)CS1 maint: unflagged free DOI (link)