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Anaritide

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Anaritide
Tertiary structure of Anaritide
Identifiers
  • L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-alanyl-L-glutaminyl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-asparagyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine
PubChem CID
Chemical and physical data
FormulaC112H177N39O35S3
Molar mass2726.07 g·mol−1
3D model (JSmol)
  • CCC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CO)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)N

Anaritide (also known as human atrial natriuretic peptide [102-126])[1] is a synthetic analogue of atrial natriuretic peptide[2] (ANP).

Structure

Anartidine has the following primary structure: [3]


RSSCFGGRMDRIGAQSGLGCNSFRY


This structure is identical to residues 102-126 of human preproANP.[1][4] In comparison, active human ANP comprises resides 99-126 of human preproANP.[5]



Medical Uses

Anaritide has been investigated as a potential therapy for acute tubular necrosis but was shown not to improve the dialysis-free survivial of these patients.[2] It also appears to exacerbate proteinuria and natriuresis in patients with nephrotic syndrome.[6]


References

  1. ^ a b Engleback, I. M.; Lappe, R. W.; Hand, J. M. (1988-07-22). "Bronchoprotective and bronchodilator activity of anaritide (human atrial natriuretic factor [102–126]) infusion in the anesthetized guinea pig". Pulmonary Pharmacology. 1 (3): 119–123. doi:10.1016/S0952-0600(88)80009-7. PMID 2980981.
  2. ^ a b Allgren, Robin L (1997-03-20). "Anaritide in Acute Tubular Necrosis". The New England Journal of Medicine. 336 (12): 828–834. doi:10.1056/NEJM199703203361203. PMID 9062091.
  3. ^ Sato, M.; Anno, I.; Yamaguchi, M.; Iida, H.; Orii, K. (2006). "Anaritide compound summary". Cardiovascular and Interventional Radiology. 29 (3): 432–434. doi:10.1007/s00270-005-0036-x. PMID 16132382.
  4. ^ Yandle, Tim; Crozier, Ian; Nicholls, Gary; Espiner, Eric; Carne, Alan; Brennan, Stephen (1987-07-31). "Amino acid sequence of atrial natriuretic peptides in human coronary sinus plasma". Biochemical and Biophysical Research Communications. 146 (2): 832–839. doi:10.1016/0006-291X(87)90606-1. PMID 2956952.
  5. ^ Rosenzweig, Anthony; Seidman, Christine E. (1991). "Atrial Natriuretic Factor and Related Peptide Hormones". Annual Review of Biochemistry. 60: 229–255. doi:10.1146/annurev.bi.60.070191.001305. PMID 1652921.
  6. ^ Zietse, Robert; Schalekamp, Maarten A. (November 1988). "Effect of synthetic human atrial natriuretic peptide (102-126) in nephrotic syndrome". Kidney International. 34 (5): 717–724. doi:10.1038/ki.1988.238. PMID 2974095.
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