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Matthew Sacchet

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Matthew Sacchet
NationalityAmerican
Alma materStanford University (Ph.D.) Brown University (Sc.B.)
Known forBrain connectivity in meditation and depression
Scientific career
FieldsNeurosciences
InstitutionsHarvard University (2019-present)


Matthew D. Sacchet is an American neuroscientist and Assistant Professor of Psychiatry at Harvard University.[1] At McLean Hospital, Sacchet directs the Meditation Research Group.[2] His research focuses on meditation and mood and anxiety disorders and includes studies of brain connectivity using multimodal neuroimaging, in addition to neurofeedback, clinical trials, and computational approaches (e.g., machine learning).[3] He is notable for his work at the intersection of neuroscience, meditation, and mental illness.[4] His work has been cited over 3500 times[5] and covered by major media outlets including CBS,[6] NBC,[7] NPR,[8] Time,[9] and The Wall Street Journal.[10] In 2017 Forbes Magazine selected Sacchet for the “30 Under 30”.[11]

Education

Sacchet received a Sc.B. in Contemplative Science from Brown University and a Ph.D. in Neurosciences from Stanford University.[12]

Academia

Career

Sacchet has held research positions at Brown University, Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology, University of Tübingen, and Stanford University.[13][14] Since 2019, he has been faculty at Harvard Medical School and McLean Hospital where he directs the Meditation Research Group.[15] The Meditation Research Group uses scientific research approaches from affective and cognitive neuroscience, clinical psychology and psychiatry, computer science and related computational disciplines, contemplative and religious studies, neuro- and micro-phenomenology, human neuroimaging, and psychoneuroimmunology including epigenetics and stress physiology.[16] The goal of the Meditation Research Group is to “[reduce] suffering and improv[e] well-being by informing the development of improved meditation training and meditation-based interventions that are more effective, efficient, and targeted.”[17]

Work

Sacchet’s work has influenced several areas of neuroscience, including: 1. brain connectivity in depression (e.g.,[18][19][20][21][22]); 2. Machine learning and person-specific biomarkers for depression (e.g.,[23][24][25][26]); 3. depression and the brain across the lifespan (e.g.,[27][28][29][30]); and 4. meditation and depression (e.g.,[31][32][33][34]).

References

  1. ^ "Matthew D. Sacchet". Harvard Brain Science Initiative. Retrieved 2021-09-27.
  2. ^ "Matthew D. Sacchet". Harvard Brain Science Initiative. Retrieved 2021-09-27.
  3. ^ "Publications".{{cite web}}: CS1 maint: url-status (link)
  4. ^ "Matthew Sacchet". Forbes. Retrieved 2021-09-27.
  5. ^ "Matthew D. Sacchet". scholar.google.com. Retrieved 2021-09-27.
  6. ^ "Mindfulness". www.cbsnews.com. Retrieved 2021-09-27.
  7. ^ Lewis, Tanya. "How Your Brain Ignores Distractions". NBC News. Retrieved 2021-09-27.
  8. ^ "Pain Really Is All In Your Head And Emotion Controls Intensity". NPR.org. Retrieved 2021-09-27.
  9. ^ "Why the Patriots Will Forget About Deflategate". Time. Retrieved 2021-09-27.
  10. ^ Hsu, Michael (2015-12-31). "Can Meditation Gadgets Help You Reduce Your Stress—and Find Happiness?". Wall Street Journal. ISSN 0099-9660. Retrieved 2021-09-27.
  11. ^ "Matthew Sacchet". Forbes. Retrieved 2021-09-27.
  12. ^ "CDASR | Matthew Sacchet, PhD". cdasr.mclean.harvard.edu. Retrieved 2021-09-27.
  13. ^ "Matthew Sacchet".{{cite web}}: CS1 maint: url-status (link)
  14. ^ "Meditation | Research". meditation.mclean.harvard.edu. Retrieved 2021-09-27.
  15. ^ "Matthew D. Sacchet". Harvard Brain Science Initiative. Retrieved 2021-09-27.
  16. ^ "Matthew D. Sacchet". Harvard Brain Science Initiative. Retrieved 2021-09-27.
  17. ^ "Matthew D. Sacchet". Harvard Brain Science Initiative. Retrieved 2021-09-27.
  18. ^ Sacchet, Matthew D; Ho, Tiffany C; Connolly, Colm G; Tymofiyeva, Olga; Lewinn, Kaja Z; Han, Laura KM; Blom, Eva H; Tapert, Susan F; Max, Jeffrey E; Frank, Guido KW; Paulus, Martin P (November 2016). "Large-Scale Hypoconnectivity Between Resting-State Functional Networks in Unmedicated Adolescent Major Depressive Disorder". Neuropsychopharmacology. 41 (12): 2951–2960. doi:10.1038/npp.2016.76. ISSN 0893-133X. PMC 5061890. PMID 27238621.
  19. ^ Ho, Tiffany C; Sacchet, Matthew D; Connolly, Colm G; Margulies, Daniel S; Tymofiyeva, Olga; Paulus, Martin P; Simmons, Alan N; Gotlib, Ian H; Yang, Tony T (November 2017). "Inflexible Functional Connectivity of the Dorsal Anterior Cingulate Cortex in Adolescent Major Depressive Disorder". Neuropsychopharmacology. 42 (12): 2434–2445. doi:10.1038/npp.2017.103. ISSN 0893-133X. PMC 5645733. PMID 28553837.
  20. ^ Pines, Adam R.; Sacchet, Matthew D.; Kullar, Monica; Ma, Jun; Williams, Leanne M. (December 2018). "Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity". Scientific Reports. 8 (1): 14032. doi:10.1038/s41598-018-32394-2. ISSN 2045-2322. PMC 6145883. PMID 30232351.
  21. ^ Hamilton, J. Paul; Sacchet, Matthew D.; Hjørnevik, Trine; Chin, Frederick T.; Shen, Bin; Kämpe, Robin; Park, Jun Hyung; Knutson, Brian D.; Williams, Leanne M.; Borg, Nicholas; Zaharchuk, Greg (2018-11-30). "Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent 11C-raclopride positron emission tomography and functional magnetic resonance imaging investigation". Translational Psychiatry. 8 (1): 1–10. doi:10.1038/s41398-018-0316-2. ISSN 2158-3188. PMC 6269434. PMID 30504860.
  22. ^ Sacchet, Matthew D; Prasad, Gautam; Foland-Ross, Lara C; Joshi, Shantanu H; Hamilton, J; Thompson, Paul M; Gotlib, Ian H (2014). "Structural abnormality of the corticospinal tract in major depressive disorder". Biology of Mood & Anxiety Disorders. 4 (1): 8. doi:10.1186/2045-5380-4-8. ISSN 2045-5380. PMC 4187017. PMID 25295159.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  23. ^ Sacchet, Matthew D.; Prasad, Gautam; Foland-Ross, Lara C.; Thompson, Paul M.; Gotlib, Ian H. (2015-02-18). "Support Vector Machine Classification of Major Depressive Disorder Using Diffusion-Weighted Neuroimaging and Graph Theory". Frontiers in Psychiatry. 6. doi:10.3389/fpsyt.2015.00021. ISSN 1664-0640. PMC 4332161. PMID 25762941.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  24. ^ Sacchet, Matthew D.; Livermore, Emily E.; Iglesias, Juan Eugenio; Glover, Gary H.; Gotlib, Ian H. (September 2015). "Subcortical volumes differentiate Major Depressive Disorder, Bipolar Disorder, and remitted Major Depressive Disorder". Journal of Psychiatric Research. 68: 91–98. doi:10.1016/j.jpsychires.2015.06.002.
  25. ^ Foland‐Ross, Lara C.; Sacchet, Matthew D.; Prasad, Gautam; Gilbert, Brooke; Thompson, Paul M.; Gotlib, Ian H. (November 2015). "Cortical thickness predicts the first onset of major depression in adolescence". International Journal of Developmental Neuroscience. 46 (1): 125–131. doi:10.1016/j.ijdevneu.2015.07.007. ISSN 0736-5748. PMC 4604750. PMID 26315399.
  26. ^ Kambeitz, Joseph; Cabral, Carlos; Sacchet, Matthew D.; Gotlib, Ian H.; Zahn, Roland; Serpa, Mauricio H.; Walter, Martin; Falkai, Peter; Koutsouleris, Nikolaos (September 2017). "Detecting Neuroimaging Biomarkers for Depression: A Meta-analysis of Multivariate Pattern Recognition Studies". Biological Psychiatry. 82 (5): 330–338. doi:10.1016/j.biopsych.2016.10.028.
  27. ^ Miller, Chris H.; Hamilton, J. Paul; Sacchet, Matthew D.; Gotlib, Ian H. (2015-10-01). "Meta-analysis of Functional Neuroimaging of Major Depressive Disorder in Youth". JAMA Psychiatry. 72 (10): 1045. doi:10.1001/jamapsychiatry.2015.1376. ISSN 2168-622X.
  28. ^ Ho, Tiffany C.; Zhang, Shunan; Sacchet, Matthew D.; Weng, Helen; Connolly, Colm G.; Henje Blom, Eva; Han, Laura K. M.; Mobayed, Nisreen O.; Yang, Tony T. (2016-02-01). "Fusiform Gyrus Dysfunction is Associated with Perceptual Processing Efficiency to Emotional Faces in Adolescent Depression: A Model-Based Approach". Frontiers in Psychology. 7. doi:10.3389/fpsyg.2016.00040. ISSN 1664-1078. PMC 4740953. PMID 26869950.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  29. ^ Sacchet, Matthew D.; Camacho, M. Catalina; Livermore, Emily E.; Thomas, Ewart A.C.; Gotlib, Ian H. (2017-05-01). "Accelerated aging of the putamen in patients with major depressive disorder". Journal of Psychiatry & Neuroscience. 42 (3): 164–171. doi:10.1503/jpn.160010. PMC 5403661. PMID 27749245.
  30. ^ Tymofiyeva, Olga; Connolly, Colm G.; Ho, Tiffany C.; Sacchet, Matthew D.; Henje Blom, Eva; LeWinn, Kaja Z.; Xu, Duan; Yang, Tony T. (January 2017). "DTI-based connectome analysis of adolescents with major depressive disorder reveals hypoconnectivity of the right caudate". Journal of Affective Disorders. 207: 18–25. doi:10.1016/j.jad.2016.09.013. PMC 5107159. PMID 27673479.
  31. ^ Roberts-Wolfe, Douglas; Sacchet, Matthew; Hastings, Elizabeth; Roth, Harold; Britton, Willoughby (2012). "Mindfulness Training Alters Emotional Memory Recall Compared to Active Controls: Support for an Emotional Information Processing Model of Mindfulness". Frontiers in Human Neuroscience. 6. doi:10.3389/fnhum.2012.00015. ISSN 1662-5161. PMC 3277910. PMID 22347856.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  32. ^ Kerr, Catherine E.; Sacchet, Matthew D.; Lazar, Sara W.; Moore, Christopher I.; Jones, Stephanie R. (2013). "Mindfulness starts with the body: somatosensory attention and top-down modulation of cortical alpha rhythms in mindfulness meditation". Frontiers in Human Neuroscience. 7. doi:10.3389/fnhum.2013.00012. ISSN 1662-5161. PMC 3570934. PMID 23408771.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  33. ^ van Lutterveld, Remko; Houlihan, Sean D.; Pal, Prasanta; Sacchet, Matthew D.; McFarlane-Blake, Cinque; Patel, Payal R.; Sullivan, John S.; Ossadtchi, Alex; Druker, Susan; Bauer, Clemens; Brewer, Judson A. (May 2017). "Source-space EEG neurofeedback links subjective experience with brain activity during effortless awareness meditation". NeuroImage. 151: 117–127. doi:10.1016/j.neuroimage.2016.02.047. PMC 5001938. PMID 26921712.
  34. ^ Lifshitz, Michael; Sacchet, Matthew D.; Huntenburg, Julia M.; Thiery, Thomas; Fan, Yan; Gärtner, Matti; Grimm, Simone; Winnebeck, Emilia; Fissler, Maria; Schroeter, Titus A.; Margulies, Daniel S. (2019). "Mindfulness-Based Therapy Regulates Brain Connectivity in Major Depression". Psychotherapy and Psychosomatics. 88 (6): 375–377. doi:10.1159/000501170. ISSN 0033-3190.

External Links

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