NPM1

Template:PBB Nucleophosmin (nucleolar phosphoprotein B23, numatrin), also known as NPM1, is a human protein and gene. It is associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may be involved in the assembly and/or transport of ribosome.Its regulation through SUMOylation (by SENP3 and SENP5) is another facet of the proteins's regulation and cellular functions.

It is located in nucleolus, but it can be translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia. The protein is phosphorylated.

Chromosomal aberrations involving NPM1 were found in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, and acute myelogenous leukemia.

Further reading

• Haindl M, Harasim T, Eick D; et al. (2008). "The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing

". EMBO reports. 9 (3): 273–279. PMID PMC2267381. {{cite journal}}: Check |pmid= value (help); Explicit use of et al. in: |author= (help); Text "doi:10.1038/embor.2008.3" ignored (help); line feed character in |title= at position 123 (help)CS1 maint: multiple names: authors list (link)}}

• Li L, Li HS, Pauza CD; et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Gjerset RA (2007). "DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer". J. Mol. Histol. 37 (5–7): 239–51. doi:10.1007/s10735-006-9040-y. PMID 16855788.
• Chen W, Rassidakis GZ, Medeiros LJ (2006). "Nucleophosmin gene mutations in acute myeloid leukemia". Arch. Pathol. Lab. Med. 130 (11): 1687–92. PMID 17076533.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Falini B, Nicoletti I, Bolli N; et al. (2007). "Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias". Haematologica. 92 (4): 519–32. doi:10.3324/haematol.11007. PMID 17488663. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Fankhauser C, Izaurralde E, Adachi Y; et al. (1991). "Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element". Mol. Cell. Biol. 11 (5): 2567–75. PMID 2017166. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Venkatesh LK, Mohammed S, Chinnadurai G (1990). "Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization". Virology. 176 (1): 39–47. doi:10.1016/0042-6822(90)90228-J. PMID 2109912.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Cochrane AW, Perkins A, Rosen CA (1990). "Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function". J. Virol. 64 (2): 881–5. PMID 2404140.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Chan PK, Chan WY, Yung BY; et al. (1986). "Amino acid sequence of a specific antigenic peptide of protein B23". J. Biol. Chem. 261 (30): 14335–41. PMID 2429957. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Zhang XX, Thomis DC, Samuel CE (1989). "Isolation and characterization of a molecular cDNA clone of a human mRNA from interferon-treated cells encoding nucleolar protein B23, numatrin". Biochem. Biophys. Res. Commun. 164 (1): 176–84. doi:10.1016/0006-291X(89)91699-9. PMID 2478125.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Hale TK, Mansfield BC (1990). "Nucleotide sequence of a cDNA clone representing a third allele of human protein B23". Nucleic Acids Res. 17 (23): 10112. PMID 2602120.
• Chan WY, Liu QR, Borjigin J; et al. (1989). "Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth". Biochemistry. 28 (3): 1033–9. doi:10.1021/bi00429a017. PMID 2713355. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Li XZ, McNeilage LJ, Whittingham S (1989). "The nucleotide sequence of a human cDNA encoding the highly conserved nucleolar phosphoprotein B23". Biochem. Biophys. Res. Commun. 163 (1): 72–8. doi:10.1016/0006-291X(89)92100-1. PMID 2775293.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Chan PK, Aldrich M, Cook RG, Busch H (1986). "Amino acid sequence of protein B23 phosphorylation site". J. Biol. Chem. 261 (4): 1868–72. PMID 3944116.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Bocker T, Bittinger A, Wieland W; et al. (1995). "In vitro and ex vivo expression of nucleolar proteins B23 and p120 in benign and malignant epithelial lesions of the prostate". Mod. Pathol. 8 (3): 226–31. PMID 7542384. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Dundr M, Leno GH, Hammarskjöld ML; et al. (1995). "The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein". J. Cell. Sci. 108 ( Pt 8): 2811–23. PMID 7593322. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Miyazaki Y, Takamatsu T, Nosaka T; et al. (1995). "The cytotoxicity of human immunodeficiency virus type 1 Rev: implications for its interaction with the nucleolar protein B23". Exp. Cell Res. 219 (1): 93–101. doi:10.1006/excr.1995.1209. PMID 7628555. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Szebeni A, Herrera JE, Olson MO (1995). "Interaction of nucleolar protein B23 with peptides related to nuclear localization signals". Biochemistry. 34 (25): 8037–42. doi:10.1021/bi00025a009. PMID 7794916.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Marasco WA, Szilvay AM, Kalland KH; et al. (1995). "Spatial association of HIV-1 tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells". Arch. Virol. 139 (1–2): 133–54. doi:10.1007/BF01309460. PMID 7826206. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
• Valdez BC, Perlaky L, Henning D; et al. (1994). "Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23". J. Biol. Chem. 269 (38): 23776–83. PMID 8089149. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)

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