Rampage (franchise)
Rampage is a series of video games released by Midway for various consoles. The basic premise of the series is that, due to a lab accident, the player controls a human transformed into a giant monster. The game-play revolves around using your monster to destroy cities around the world while attacking or avoiding police and military forces.
The most recent "Rampage" game is the Wii version of "Rampage: Total Destruction" (which was released on November 19, 2006 (nearly nine months after the original GameCube video game release of the same name).
As of 2011, it's currently unknown whether or not there will be a sixth installment, a second spin-off, or anything in that matter.